Dental pulp mesenchymal stem cell-derived exosomes alleviate intervertebral disc degeneration by inhibition of macrophage M1 polarization
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Spine and Intervertebral Disc Pathology · Cervical and Thoracic Myelopathy · Immune cells in cancer
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (56)
Show source-provided references
1. Chronic Low Back Pain IPD Meta-Analysis Group, Exercise treatment effect modifiers in persistent low back pain: an individual participant data meta-analysis of 3514 participants from 27 randomised controlled trials10.1136/bjsports-2019-101205 ↗
2. Global, Regional, and National Burden of Low Back Pain: Findings From the Global Burden of Disease Study 2021 and Projections to 205010.1097/BRS.0000000000005265 ↗
3. Low back pain10.1016/S0140-6736(21)00733-9 ↗
4. Lumbar adjacent segment degeneration after spinal fusion surgery: a systematic review and meta-analysis10.23736/S0390-5616.22.05891-X ↗
5. The biomechanical changes of facet joint violation after transforaminal lumbar interbody fusion combined with decompression surgery: a finite element study
6. Complications and readmission after lumbar spine surgery in elderly patients: an analysis of 2,320 patients10.1016/j.spinee.2017.03.019 ↗
7. Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop10.1038/s41413-020-0087-2 ↗
8. Macrophages and Intervertebral Disc Degeneration10.3390/ijms24021367 ↗
9. Role of macrophage in intervertebral disc degeneration10.1038/s41413-024-00397-7 ↗
10. Excessive cholesterol accelerates intervertebral disc degeneration by promoting the polarization of M1 macrophages10.1186/s12944-025-02709-0 ↗
11. Secreted Factors From Intervertebral Disc Cells and Infiltrating Macrophages Promote Degenerated Intervertebral Disc Catabolism10.1097/BRS.0000000000002953 ↗
12. Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages10.1186/s12951-023-02075-y ↗
13. Exosome-Based Therapeutics for Musculoskeletal Disorders: Advances in Engineering, Targeting, and Biomaterial Integration10.1021/acsnano.5c05416 ↗
14. Engineered Apoptotic Extracellular Vesicles for Programmable Regulation of Neutrophil-Macrophage-ROS Pathogenic Axis to Reconstruct Rheumatoid Arthritis Microenvironment10.1002/adma.202508072 ↗
15. Mesenchymal Stem Cell-Derived Exosomes as Drug Delivery Vehicles in Disease Therapy10.3390/ijms25147715 ↗
16. Molecularly Engineered Macrophage-Derived Exosomes with Inflammation Tropism and Intrinsic Heme Biosynthesis for Atherosclerosis Treatment10.1002/anie.201913700 ↗
17. The biology, function, and biomedical applications of exosomes10.1126/science.aau6977 ↗
18. Small Extracellular Vesicles Released from Bioglass/Hydrogel Scaffold Promote Vascularized Bone Regeneration by Transferring miR-23a-3p10.2147/IJN.S389471 ↗
19. Dual Exosome Coating for Modulating Endothelial Function and Inflammation10.1021/acsami.5c02721 ↗
20. Mineralized osteoblast-derived exosomes and 3D-printed ceramic-based scaffolds for enhanced bone healing: A preclinical exploration10.1016/j.actbio.2025.05.051 ↗
21. Molecular Mechanisms Responsible for the Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Lung Fibrosis10.3390/ijms25084378 ↗
22. Different origin-derived exosomes and their clinical advantages in cancer therapy10.3389/fimmu.2024.1401852 ↗
23. Mesenchymal stem cell–derived extracellular vesicles: A novel nanoimmunoregulatory tool in musculoskeletal diseases10.1016/j.nantod.2024.102343 ↗
24. Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: Review10.3390/ijms23137306 ↗
25. Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration10.1186/s12951-021-00991-5 ↗
26. MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf210.1016/j.freeradbiomed.2025.04.051 ↗
27. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo10.1073/pnas.240309797 ↗
28. Dental Pulp Stem Cell-Derived Exosomes Regulate Anti-Inflammatory and Osteogenesis in Periodontal Ligament Stem Cells and Promote the Repair of Experimental Periodontitis in Rats10.2147/IJN.S420967 ↗
29. Dental Pulp Stem Cell-Derived Exosomes Alleviate Mice Knee Osteoarthritis by Inhibiting TRPV4-Mediated Osteoclast Activation10.3390/ijms24054926 ↗
30. Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury10.1186/s12951-022-01273-4 ↗
31. Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells10.1007/s12026-019-09088-6 ↗
32. Dental pulp mesenchymal stem cell-derived exosomes inhibit neuroinflammation and microglial pyroptosis in subarachnoid hemorrhage via the miRNA-197-3p/FOXO3 axis10.1186/s12951-024-02708-w ↗
33. Biomaterials delivery strategies to repair degenerated intervertebral discs by regulating the inflammatory microenvironment10.3389/fimmu.2023.1051606 ↗
34. Single-cell RNA-seq analysis reveals that immune cells induce human nucleus pulposus ossification and degeneration
35. Exploring macrophage differentiation and its relation to Modic changes in human herniated disc tissue10.1016/j.bas.2022.101698 ↗
36. Stem cell exosomes: new hope and future potential for relieving liver fibrosis10.3350/cmh.2024.0854 ↗
37. Huc-MSCs-derived exosomes alleviate non-alcoholic steatohepatitis by regulating macrophages polarization through miR-24-3p/STING axis10.1186/s13287-025-04197-6 ↗
38. Mesenchymal Stem Cell-Derived Exosomes Promote Recovery of The Facial Nerve Injury through Regulating Macrophage M1 and M2 Polarization by Targeting the P38 MAPK/NF-Κb Pathway10.14336/AD.2023.0719-1 ↗
39. A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration10.1038/s41467-025-63194-8 ↗
40. Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery10.1073/pnas.2314747121 ↗
41. Progress in regulating inflammatory biomaterials for intervertebral disc regeneration
42. Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions10.1038/s41413-020-00125-x ↗
43. Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration10.1038/s41419-017-0085-5 ↗
44. Role of cytokines in intervertebral disc degeneration: pain and disc content10.1038/nrrheum.2013.160 ↗
45. Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics10.1093/nar/gkae973 ↗
46. Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy10.7150/ijbs.77987 ↗
47. Serine metabolism orchestrates macrophage polarization by regulating the IGF1-p38 axis10.1038/s41423-022-00925-7 ↗
48. USP7 inhibits the progression of nasopharyngeal carcinoma via promoting SPLUNC1-mediated M1 macrophage polarization through TRIM2410.1038/s41419-023-06368-w ↗
49. Nuclear factor κB overactivation in the intervertebral disc leads to macrophage recruitment and severe disc degeneration10.1126/sciadv.adj3194 ↗
50. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways10.1038/aps.2013.24 ↗
51. Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure-activity relationships10.1016/j.cbi.2008.04.015 ↗
52. MAPK signal pathways in the regulation of cell proliferation in mammalian cells10.1038/sj.cr.7290105 ↗
53. Organophosphorus Compounds and MAPK Signaling Pathways10.3390/ijms21124258 ↗
54. Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism
55. Isolation and characterization of exosomes from cell culture supernatants and biological fluids
56. Hypoxia-Preconditioned BMSC-Derived Exosomes Induce Mitophagy via the BNIP3-ANAX2 Axis to Alleviate Intervertebral Disc Degeneration