journal article·2026-06

Aromaticity-donated preferable prodrug nanoassembly: Deciphering the underlying roles of π-conjugation in self-aggregation and drug activation

Yao Chen, Yuequan Wang, Haimeng Yuan, Yifan Wang, Xinran Li, Qin Chen, Hongyuan Zhang, Shenwu Zhang, Cong Luo

Nano Today· Volume 69
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Abstract

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OpenAlex topics: Supramolecular Self-Assembly in Materials · Supramolecular Chemistry and Complexes · Chemical Synthesis and Analysis

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References (44)

Show source-provided references
1. Cancer statistics 2024: All hands on deck
2. Kim · Nat. Med. · 2025 · 3110.1038/s41591-025-03502-3 ↗
3. First-line sugemalimab plus chemotherapy for advanced gastric cancer: the GEMSTONE-303 randomized clinical trial10.1001/jama.2024.28463 ↗
4. Chen · Chin. Chem. Lett. · 2024 · 35
5. Hoeppner · N. Engl. J. Med. · 2025 · 392 · 32310.1056/NEJMoa2409408 ↗
6. Liu · J. Clin. Oncol. · 2025 · 43
7. Abstract 2075: differential tissue clearance results in improved therapeutic index for irinotecan liposome injection (ONIVYDE) when combined with the PARP inhibitor veliparib in preclinical cervical tumors10.1158/1538-7445.AM2016-2075 ↗
8. de Sáa · J. Hematol. Oncol. · 2023 · 16
9. Wang · J. Hematol. Oncol. · 2025 · 18
10. Wei · Chin. Chem. Lett. · 2023 · 34
11. Dynamic covalent chemistry-regulated stimuli-activatable drug delivery systems for improved cancer therapy10.1016/j.cclet.2019.12.002 ↗
12. Clinical cancer nanomedicine10.1016/j.nantod.2019.02.005 ↗
13. Design considerations for organ-selective nanoparticles10.1021/acsnano.5c00484 ↗
14. Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer10.1093/annonc/mdl104 ↗
15. EORTC 10968: a phase I clinical and pharmacokinetic study of polyethylene glycol liposomal doxorubicin (Caelyx, Doxil) at a 6-week interval in patients with metastatic breast cancer. European Organization for Research and Treatment of Cancer10.1093/annonc/mdf157 ↗
16. Lipid-based nanoparticles external triggered release strategies in cancer nanomedicine10.1186/s12951-025-03704-4 ↗
17. Bioengineered platelets combining chemotherapy and immunotherapy for postsurgical melanoma treatment: internal core-loaded doxorubicin and external surface-anchored anti-PD-L1 antibody backpacks10.1021/acs.nanolett.2c00907 ↗
18. Three birds with one stone: multi-functional interface strengthening to construct self-warning smart coatings with integrated corrosion and fouling resistance10.1007/s42114-025-01489-6 ↗
19. Surface-anchored ticagrelor gelatin nanoparticles-platelets system for enhanced anti-PD-L1 therapy response and boosted chemotherapeutic efficacy of nanomedicines10.1002/EXP.20240084 ↗
20. Elaborately engineering of a dual-drug co-assembled nanomedicine for boosting immunogenic cell death and enhancing triple negative breast cancer treatment
21. 18 On-site self-penetrating nanomedicine enabling dual-priming drug activation and inside-out thrombus ablation10.1021/acsnano.4c09986 ↗
22. Iron selenide nanoparticles-encapsulated within bamboo-like N-doped carbon nanotubes as composite anodes for superior lithium and sodium-ion storage
23. High spatiotemporal tracking of intestinal peristalsis and bowel disease via in situ generated NIR-II cyanine-albumin complex
24. Zhang · Nat. Commun. · 2023 · 14
25. Yang · Adv. Sci. · 2024 · 11
26. Termini restraining of small membrane proteins enables structure determination at near-atomic resolution
27. Tetrasulfide bond boosts the anti-tumor efficacy of dimeric prodrug nanoassemblies
28. AIEgen-functionalized nanoprobes and nanomedicines for cancer diagnosis and therapy10.1016/j.ccr.2024.216148 ↗
29. Microbiotic nanomedicine for tumor-specific chemotherapy-synergized innate/adaptive antitumor immunity10.1016/j.nantod.2022.101377 ↗
30. Self-adaptive nanoassembly enabling turn-on hypoxia illumination and periphery/center closed-loop tumor eradication
31. Long-acting bioengineered platelets with internal doxorubicin loaded and external quercetin liposomes anchored for post-surgical tumor therapy10.1016/j.jconrel.2025.02.042 ↗
32. A natural compound-empowered podophyllotoxin prodrug nanoassembly magnifies efficacy-toxicity benefits in cancer chemotherapy
33. Myeloperoxidase-mimetic nanozyme generates hypochlorous acid for phagosomal bacteria elimination
34. Li · Nat. Commun. · 2019
35. Modularly engineered prodrug-nanoassemblies for cancer therapy: nonpharmacological moiety dominating delivery fates10.1007/s12274-022-4819-z ↗
36. Steric hindrance-engineered redox-responsive disulfide-bridged homodimeric prodrug nanoassemblies for spatiotemporally balanced cancer chemotherapy10.1021/acs.jmedchem.5c00810 ↗
37. Zhou · Adv. Sci. · 2024 · 11
38. Self-assembled homopolymeric spherulites from small molecules in solution10.1021/jacs.3c08356 ↗
39. Disulfide bond-driven nanoassembly of lipophilic epirubicin prodrugs for breast cancer therapy10.1007/s40005-025-00731-z ↗
40. Fu · Sci. Adv. · 2025 · 11
41. Gao · Angew. Chem. -Int. Ed. · 2025 · 64
42. Xi · Adv. Mater. · 2022 · 34
43. Li · Nat. Commun. · 2025 · 16
44. Viologen derivatives with extended π-conjugation structures: From supra-/molecular building blocks to organic porous materials10.1016/j.cclet.2019.12.039 ↗