Mutational effects on conformational plasticity redirect the aggregation pathways of intrinsically disordered peptides
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OpenAlex topics: Protein Structure and Dynamics · Supramolecular Self-Assembly in Materials · Chemical Synthesis and Analysis
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References (50)
Show source-provided references
1. Direct prediction of intrinsically disordered protein conformational properties from sequence10.1038/s41592-023-02159-5 ↗
2. The molecular basis for cellular function of intrinsically disordered protein regions10.1038/s41580-023-00673-0 ↗
3. Mutations in disordered regions can cause disease by creating dileucine motifs10.1016/j.cell.2018.08.019 ↗
4. Human diseases from gain-of-function mutations in disordered protein regions10.1016/j.cell.2018.08.059 ↗
5. Disease mutations in disordered regions--exception to the rule?10.1039/C1MB05251A ↗
6. Phase separation as a missing mechanism for interpretation of disease mutations10.1016/j.cell.2020.11.050 ↗
7. Single-point mutations in disordered proteins: linking sequence, ensemble, and function10.1016/j.sbi.2025.102987 ↗
8. IDPs in macromolecular complexes: the roles of multivalent interactions in diverse assemblies10.1016/j.sbi.2017.12.007 ↗
9. Missense mutations in intrinsically disordered protein regions link pathogenicity and phase separation
10. A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins10.1016/j.cell.2018.06.006 ↗
11. Mutations in tau protein promote aggregation by favoring extended conformations10.1021/jacsau.3c00550 ↗
12. Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity10.1038/s41467-020-16564-3 ↗
13. The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity10.1038/s41594-023-00920-0 ↗
14. Single amino acid substitutions in stickers, but not spacers, substantially alter UBQLN2 phase transitions and dense phase material properties10.1021/acs.jpcb.9b01024 ↗
15. pH induced switch in the conformational ensemble of intrinsically disordered protein prothymosin-α and its implications for amyloid fibril formation10.1021/acs.jpclett.2c01972 ↗
16. Selective molecular recognition in amyloid growth and transmission and cross-species barriers10.1016/j.jmb.2011.11.023 ↗
17. Cancer-associated mutations perturb the disordered ensemble and interactions of the intrinsically disordered p53 transactivation domain10.1016/j.jmb.2021.167048 ↗
18. Ensemble description of the intrinsically disordered N-terminal domain of the Nipah virus P/V protein from combined NMR and SAXS10.1038/s41598-020-76522-3 ↗
19. Interplay of protein disorder in retinoic acid receptor heterodimer and its corepressor regulates gene expression10.1016/j.str.2019.05.001 ↗
20. Intrinsically disordered proteins studied by NMR spectroscopy
21. Quantitative description of intrinsically disordered proteins using single-molecule FRET NMR, and SAXS10.1021/jacs.1c06264 ↗
22. α-Synuclein aggregation nucleates through liquid-liquid phase separation10.1038/s41557-020-0465-9 ↗
23. FUS fibrillation occurs through a nucleation-based process below the critical concentration required for liquid-liquid phase separation10.1038/s41598-023-34558-1 ↗
24. Amyloid-β modulates the phase separation and aggregation of α-synuclein10.1073/pnas.2501987122 ↗
25. A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis10.1038/s41422-025-01125-4 ↗
26. Binding memory of liquid molecules10.1038/s41467-025-61630-3 ↗
27. Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses10.1016/0092-8674(91)90051-Y ↗
28. Novel keratin 14 gene mutations in patients from Hungary with epidermolysis bullosa simplex10.1111/j.0906-6705.2004.0120.x ↗
29. Keratin 14 gene mutations in patients with epidermolysis bullosa simplex10.1111/1523-1747.ep12323846 ↗
30. Laryngeal involvement in the Dowling-Meara variant of epidermolysis bullosa simplex with keratin mutations of severely disruptive potential10.1046/j.1365-2133.2000.03304.x ↗
31. Introduction to Bioorganic Chemistry and Chemical Biology
32. Validity of using the radius of gyration as a restraint in NMR protein structure determination10.1021/ja005770p ↗
33. End-to-end distance distributions and intrachain diffusion constants in unfolded polypeptide chains indicate intramolecular hydrogen bond formation10.1073/pnas.0604748103 ↗
34. Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T10.1126/sciadv.abc1449 ↗
35. Beyond the amyloid core: modulation of aggregate conformational diversity by mutations in the noncore regions10.1021/jacs.5c07880 ↗
36. The free energy folding penalty accompanying binding of intrinsically disordered α-helical motifs10.1002/pro.4370 ↗
37. Residual structure accelerates binding of intrinsically disordered ACTR by promoting efficient folding upon encounter10.1016/j.jmb.2018.12.001 ↗
38. A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded polypeptides10.1093/protein/gzp036 ↗
39. Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation10.1038/srep09228 ↗
40. Single-molecule visualization determines conformational substate ensembles in β-sheet-rich peptide fibrils10.1126/sciadv.adg7943 ↗
41. NMRPipe: a multidimensional spectral processing system based on UNIX pipes10.1007/BF00197809 ↗
42. NMR View: a computer program for the visualization and analysis of NMR data10.1007/BF00404272 ↗
43. TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts10.1007/s10858-009-9333-z ↗
44. Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA10.1016/S0022-2836(02)00241-3 ↗
45. SANE (Structure Assisted NOE Evaluation): an automated model-based approach for NOE assignment10.1023/A:1011227824104 ↗
46. The Amber biomolecular simulation programs10.1002/jcc.20290 ↗
47. AQUA and PROCHECK NMR: programs for checking the quality of protein structures solved by NMR10.1007/BF00228148 ↗
48. Raman evidence of p53-DBD disorder decrease upon interaction with the anticancer protein azurin10.3390/ijms20123078 ↗
49. Potential of Raman spectroscopic techniques to study proteins10.1016/j.saa.2021.119712 ↗
50. Molecular mechanisms of protein aggregation from global fitting of kinetic models10.1038/nprot.2016.010 ↗