Harnessing extreme organisms adaptations to develop a radiation protection agent for radiation lung injury
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Effects of Radiation Exposure · Radioactive contamination and transfer · Radiation Dose and Imaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (78)
Show source-provided references
1. Radiation-Induced Lung Injury: Assessment and Management10.1016/j.chest.2019.03.033 ↗
2. Normal Tissue Complication Probability Modeling of Pulmonary Toxicity After Stereotactic and Hypofractionated Radiation Therapy for Central Lung Tumors10.1016/j.ijrobp.2017.11.022 ↗
3. Pneumonitis Rates Before and After Adoption of Immunotherapy Consolidation in Patients With Locally Advanced Non-Small Cell Lung Cancer Treated With Concurrent Chemoradiation10.1016/j.ijrobp.2023.08.039 ↗
4. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury10.1016/j.canlet.2011.12.012 ↗
5. Oxidative stress: A critical hint in ionizing radiation induced pyroptosis10.1016/j.radmp.2020.10.001 ↗
6. The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium10.1038/nrmicro3032 ↗
7. Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury10.1038/s12276-024-01208-z ↗
8. Exploration of radiation-induced lung injury, from mechanism to treatment: a narrative review10.21037/tlcr-22-108 ↗
9. ROS function in redox signaling and oxidative stress10.1016/j.cub.2014.03.034 ↗
10. Increased susceptibility of irradiated mice to Aspergillus fumigatus infection via NLRP3/GSDMD pathway in pulmonary bronchial epithelia10.1186/s12964-022-00907-2 ↗
11. Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury10.1186/s12931-023-02331-7 ↗
12. GATA6 promotes fibrotic repair of tracheal injury through NLRP3 inflammasome-mediated epithelial pyroptosis10.1016/j.intimp.2023.110657 ↗
13. X. Liang, Y. Qin, D. Wu, Q. Wang, H. Wu, Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases, Cell Commun. Signal. 22 (2024) 40, doi:10.1186/s12964-023-01458-w.10.1186/s12964-023-01458-w ↗
14. Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis10.1007/s10565-023-09799-5 ↗
15. silencing alleviates airway inflammation and remodeling in an ovalbumin-induced asthmatic mouse model10.1038/s41419-024-06777-5 ↗
16. Pyroptosis in health and disease: mechanisms, regulation and clinical perspective10.1038/s41392-024-01958-2 ↗
17. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica10.1126/science.1156995 ↗
18. de Zoete · Inflammasomes, Cold Spring Harb. Perspect. Biol. · 2014 · 6
19. Molecular mechanisms regulating NLRP3 inflammasome activation10.1038/cmi.2015.95 ↗
20. Mechanism and Regulation of NLRP3 Inflammasome Activation10.1016/j.tibs.2016.09.002 ↗
21. The NLRP3 inflammasome: molecular activation and regulation to therapeutics10.1038/s41577-019-0165-0 ↗
22. An update on the regulatory mechanisms of NLRP3 inflammasome activation10.1038/s41423-021-00670-3 ↗
23. Gasdermin D in pyroptosis10.1016/j.apsb.2021.02.006 ↗
24. Pyroptotic cell death: an emerging therapeutic opportunity for radiotherapy10.1038/s41420-024-01802-0 ↗
25. Z. Tang, C. Li, B. Kang, G. Gao, C. Li, Z. Zhang, GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses, Nucleic Acids Res. 45 (2017) W98-W102, doi:10.1093/nar/gkx247.10.1093/nar/gkx247 ↗
26. Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions10.1186/s12964-024-01966-3 ↗
27. The role of NLRP3 inflammasome activation in radiation damage10.1016/j.biopha.2019.109217 ↗
28. TGF-beta in radiotherapy: Mechanisms of tumor resistance and normal tissues injury10.1016/j.phrs.2020.104745 ↗
29. Pulmonary Delivery of Specialized Pro-Resolving Mediators-Based Nanotherapeutics Attenuates Pulmonary Fibrosis in Preclinical Animal Models10.1021/acsnano.2c10388 ↗
30. Radiation-induced lung injury: from mechanism to prognosis and drug therapy10.1186/s13014-025-02617-8 ↗
31. ROS and ROS-Mediated Cellular Signaling10.1155/2016/4350965 ↗
32. The harmful effect of prolonged high-dose methylprednisolone in acute lung injury10.1016/j.intimp.2012.12.004 ↗
33. Serious adverse effects of amifostine during radiotherapy in head and neck cancer patients10.1016/j.radonc.2003.10.005 ↗
34. The tardigrade Hypsibius exemplaris dramatically upregulates DNA repair pathway genes in response to ionizing radiation10.1016/j.cub.2024.03.019 ↗
35. Examples of Extreme Survival: Tardigrade Genomics and Molecular Anhydrobiology10.1146/annurev-animal-021419-083711 ↗
36. Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade10.1126/science.adl0799 ↗
37. Population Response of Twelve Species of Insects following Exposure to Ionizing Radiation10.1093/aesa/64.2.456 ↗
38. The Effect of Radiation on the Longevity of the Cockroach, Periplaneta-Americana, as Affected by Dose, Age, Sex and Food Intake10.2307/3570814 ↗
39. Protective effect of an extract from Periplaneta americana on hematopoiesis in irradiated rats10.1080/09553000902985110 ↗
40. Periplaneta americana Extract Pretreatment Alleviates Oxidative Stress and Inflammation and Increases the Abundance of Gut Akkermansia muciniphila in Diquat-Induced Mice10.3390/antiox11091806 ↗
41. Antioxidative effect of Periplaneta americana extract on dextran sulfate sodium-induced ulcerative colitis through activation of the Nrf2 signal10.1080/13880209.2023.2220351 ↗
42. The effects and mechanism of Kangfuxin on improving healing quality and preventing recurrence of gastric ulcer10.1016/j.biopha.2021.111513 ↗
43. Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival10.1080/13880209.2019.1682620 ↗
44. Periplaneta americana L. as a novel therapeutics accelerates wound repair and regeneration10.1016/j.biopha.2019.108858 ↗
45. Effects of Periplaneta americana extracts on the growth and proliferation of cutaneous interstitial cells in cutaneous-wound healing10.3389/fphar.2022.920855 ↗
46. Research advances on the restorative effect of Periplaneta americana extracts on mucosa10.1016/j.heliyon.2023.e16623 ↗
47. Periplaneta americana Extracts Accelerate Liver Regeneration via a Complex Network of Pathways10.3389/fphar.2020.01174 ↗
48. Antipyretic, anti-inflammatory and analgesic activities of Periplaneta americana extract and underlying mechanisms10.1016/j.biopha.2019.109753 ↗
49. Bioactivity-Guided Screening of Wound-Healing Active Constituents from American Cockroach (Periplaneta americana)10.3390/molecules23010101 ↗
50. JAK/STAT3 and Smad3 activities are required for the wound healing properties of Periplaneta americana extracts10.3892/ijmm.2017.3040 ↗
51. Antioxidant, antibacterial, and anti-inflammatory Periplaneta americana remnant chitosan/polysaccharide composite film: In vivo wound healing application evaluation10.1016/j.ijbiomac.2023.124068 ↗
52. Isocoumarins from American cockroach (Periplaneta americana) and their cytotoxic activities10.1016/j.fitote.2014.03.004 ↗
53. Two glycoproteins from medicinal insect Periplaneta americana (L.) promote diabetic wound healing via macrophage polarization modulation10.1016/j.ijbiomac.2022.04.193 ↗
54. Characterization and diabetic wound healing benefits of protein-polysaccharide complexes isolated from an animal ethno-medicine Periplaneta americana L10.1016/j.ijbiomac.2021.12.018 ↗
55. Y. Zhao, A. Yang, P. Tu, Z. Hu, Anti-tumor effects of the American cockroach, Periplaneta americana, Chin. Med. (U. Kingd.) 12 (2017) 26, doi:10.1186/s13020-017-0149-6.10.1186/s13020-017-0149-6 ↗
56. Periplaneta americana extract improves recurrent oral ulcers through regulation of TLR4/NF-κB and Nrf2/HO-1 pathways10.1038/s41598-024-84703-7 ↗
57. Natural exosome-like nanoparticles derived from ancient medicinal insect Periplaneta americana L. as a novel diabetic wound healing accelerator10.1186/s12951-023-01923-1 ↗
58. Periplaneta americana (Insecta: Blattodea) and organ fibrosis: A mini review10.1097/MD.0000000000032039 ↗
59. Role of integrin α4 in the inhibition of fibrosis in activated hepatic stellate cells by Periplaneta americana extract10.3389/fphar.2025.1517491 ↗
60. Gastroprotective effects of Kangfuxin-against ethanol-induced gastric ulcer via attenuating oxidative stress and ER stress in mice10.1016/j.cbi.2016.10.021 ↗
61. Novel drug delivery systems and disease models for pulmonary fibrosis10.1016/j.jconrel.2022.05.039 ↗
62. Therapeutic advantage of inhaled tacrolimus-bound albumin nanoparticles in a bleomycin-induced pulmonary fibrosis mouse model10.1016/j.pupt.2016.01.001 ↗
63. Dynamic mucus penetrating microspheres for efficient pulmonary delivery and enhanced efficacy of host defence peptide (HDP) in experimental tuberculosis10.1016/j.jconrel.2020.05.013 ↗
64. Inhaled drug delivery: Past, present, and future,10.1016/j.nantod.2023.101942 ↗
65. Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse
66. Free amino acids in the hemolymph of the American cockroach, Periplaneta americana L10.1016/0010-406X(61)90017-2 ↗
67. Antioxidative effect of amino-acids10.1038/186886a0 ↗
68. Antioxidative categorization of twenty amino acids based on experimental evaluation10.3390/molecules22122066 ↗
69. A composite hydrogel loading natural polysaccharides derived from Periplaneta americana herbal residue for diabetic wound healing10.1016/j.ijbiomac.2020.08.156 ↗
70. Phytochemical Profiling, Isolation, and Pharmacological Applications of Bioactive Compounds from Insects of the Family Blattidae Together with Related Drug Development10.3390/molecules27248882 ↗
71. A polysaccharide from Periplaneta americana promotes macrophage M2 polarization, exhibiting anti-inflammatory and wound-healing activities10.1016/j.ijbiomac.2024.135836 ↗
72. Periplaneta americana ameliorates dextran sulfate sodium-induced ulcerative colitis in rats by Keap1/Nrf-2 activation, intestinal barrier function, and gut microbiota regulation10.3389/fphar.2018.00944 ↗
73. Periplaneta americana extract promotes intestinal mucosa repair of ulcerative colitis in rat10.1590/s0102-865020200100000002 ↗
74. The inhibitory effect of Periplaneta americana L. on hepatocellular carcinoma: Explore the anti-hepatocellular carcinoma active site and its mechanism of action10.1016/j.jep.2021.114884 ↗
75. Rational Design of Nanomaterials for Various Radiation-Induced Diseases Prevention and Treatment10.1002/adhm.202001615 ↗
76. Reactive Oxygen Species-Regulating Strategies Based on Nanomaterials for Disease Treatment10.1002/advs.202002797 ↗
77. TGF-beta activation and lung fibrosis10.1513/pats.201201-003AW ↗
78. K. Kahata, M.S. Dadras, A. Moustakas, TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition, Cold Spring Harb. Perspect. Biol. 10 (2018) a022194, doi:10.1101/cshperspect.a022194.10.1101/cshperspect.a022194 ↗