Lipid nanoparticle used in mRNA vaccine promotes tumor metastasis in mouse model via mtDNA-induced neutrophil activation and NETosis
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Cancer Research and Treatments · Neutrophil, Myeloperoxidase and Oxidative Mechanisms · Immune cells in cancer
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (62)
Show source-provided references
1. Tools and TEchniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 detection10.1128/CMR.00228-20 ↗
2. Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic10.1080/22221751.2021.1898291 ↗
3. A comprehensive review of the global efforts on COVID-19 vaccine development10.1021/acscentsci.1c00120 ↗
4. Lipid nanoparticles─from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement10.1021/acsnano.1c04996 ↗
5. mRNA vaccine for treating pancreatic cancer
6. A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes10.1126/science.abm0271 ↗
7. Biodegradable lipid nanoparticles for genome editing in the brain via intrathecal administration10.1016/j.mattod.2025.11.032 ↗
8. Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics10.1186/s12951-025-03195-3 ↗
9. Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies10.1038/s41467-018-05482-0 ↗
10. A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice10.1016/j.immuni.2020.07.019 ↗
11. A novel amino lipid series for mRNA delivery: improved endosomal escape and sustained pharmacology and safety in non-human primates10.1016/j.ymthe.2018.03.010 ↗
12. Branched-tail lipid nanoparticles potently deliver mRNA in vivo due to enhanced ionization at endosomal pH10.1002/smll.201805097 ↗
13. Phospholipids tailor mRNA lipid nanoparticle delivery efficacy and immunogenicity10.1016/j.mattod.2026.01.004 ↗
14. Background document on the mRNA vaccine BNT162b2 (Pfizer-BioNTech) against COVID-19: background document to the WHO Interim recommendations for use of the Pfizer–BioNTech COVID-19 vaccine
15. Independent effect of polymeric nanoparticle zeta potential/surface charge, on their cytotoxicity and affinity to cells10.1111/cpr.12192 ↗
16. vivo toxicity of cationic micelles and liposomes10.1016/j.nano.2014.08.004 ↗
17. Preliminary findings of mRNA Covid-19 vaccine safety in pregnant persons10.1056/NEJMoa2104983 ↗
18. An mRNA vaccine against SARS-CoV-2 - preliminary report10.1056/NEJMoa2022483 ↗
19. Neutrophil degranulation, plasticity, and cancer metastasis10.1016/j.it.2019.01.006 ↗
20. Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma10.1038/nature13111 ↗
21. Liver tumour immune microenvironment subtypes and neutrophil heterogeneity10.1038/s41586-022-05400-x ↗
22. Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment10.1016/j.neo.2014.08.013 ↗
23. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes10.1073/pnas.1015855107 ↗
24. Neutrophils escort circulating tumour cells to enable cell cycle progression10.1038/s41586-019-0915-y ↗
25. IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis10.1038/nature14282 ↗
26. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation10.1016/j.ccell.2020.12.012 ↗
27. Neutrophils support lung colonization of metastasis-initiating breast cancer cells10.1038/nature16140 ↗
28. Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung10.1038/s41467-020-20733-9 ↗
29. The architecture of neutrophil extracellular traps investigated by atomic force microscopy10.1039/C6NR03416K ↗
30. Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response10.1186/s13045-019-0836-0 ↗
31. Circulating mitochondrial DAMPs cause inflammatory responses to injury10.1038/nature08780 ↗
32. Carbon black nanoparticles induce cell necrosis through lysosomal membrane permeabilization and cause subsequent inflammatory response10.7150/thno.34065 ↗
33. mRNA-lipid nanoparticle COVID-19 vaccines: structure and stability10.1016/j.ijpharm.2021.120586 ↗
34. An ionizable lipid toolbox for RNA delivery10.1038/s41467-021-27493-0 ↗
35. Combining TIGIT blockade with MDSC inhibition hinders breast cancer bone metastasis by activating antitumor immunity10.1158/2159-8290.CD-23-0762 ↗
36. Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells10.1016/j.cmet.2024.04.019 ↗
37. Functional states of myeloid cells in cancer10.1016/j.ccell.2023.02.009 ↗
38. Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension10.1038/s41423-020-00608-1 ↗
39. Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis?10.1136/ard.2010.133587 ↗
40. The CCL2-CCR2 axis determines whether glomerular endocapillary hypercellularity or wire-loop lesions develop through glomerular macrophage and neutrophil infiltration in lupus nephritis10.1002/path.6331 ↗
41. The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory10.1016/j.isci.2021.103479 ↗
42. mRNA-LNP COVID-19 vaccine lipids induce complement activation and production of proinflammatory cytokines: mechanisms, effects of complement inhibitors, and relevance to adverse reactions10.3390/ijms25073595 ↗
43. VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease10.1126/science.aav4011 ↗
44. Cationic nanocarriers induce cell necrosis through impairment of Na(+)/K(+)-ATPase and cause subsequent inflammatory response10.1038/cr.2015.9 ↗
45. Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades10.1038/s41565-019-0472-4 ↗
46. Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN10.1016/j.ccr.2009.06.017 ↗
47. Estradiol promotes breast cancer cell migration via recruitment and activation of neutrophils10.1158/2326-6066.CIR-16-0150 ↗
48. Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells10.1038/s41423-022-00845-6 ↗
49. Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors10.1038/s41594-019-0334-7 ↗
50. Cell plasticity in epithelial homeostasis and tumorigenesis10.1038/ncb3611 ↗
51. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer10.1038/nature21713 ↗
52. Epithelial-mesenchymal transition and inflammation at the site of the primary tumor10.1016/j.semcancer.2017.08.002 ↗
53. Qin, Z., Bouteau, A., Herbst, C., and Igyártó, B.Z. ,2022. Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion. bioRxiv. 10.1101/2022.03.16.484616.10.1101/2022.03.16.484616 ↗
54. Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)10.1016/j.jconrel.2021.12.027 ↗
55. Neutrophils in cancer: heterogeneous and multifaceted10.1038/s41577-021-00571-6 ↗
56. Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils10.1016/j.ccell.2016.06.021 ↗
57. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice10.1126/science.aao4227 ↗
58. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones10.1371/journal.pone.0032366 ↗
59. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps10.1083/jcb.201006052 ↗
60. Histones, DNA, and citrullination promote neutrophil extracellular trap inflammation by regulating the localization and activation of TLR410.1016/j.celrep.2020.107602 ↗
61. Targeting negative surface charges of cancer cells by multifunctional nanoprobes10.7150/thno.16358 ↗
62. Endothelial glycocalyx regulates cytoadherence in Plasmodium falciparum malaria10.1098/rsif.2018.0773 ↗