Single-Atom Manganese Anchored on Carbon Dots for Promoting Mitochondrial Targeting and Photodynamic Effect in Cancer Treatment
Source abstract
Abstract
The sustained rapid growth of tumor cells depends directly on the activity of mitochondria, which are important targets for many cancer drugs. Here, we report on a self-targeting method for mitochondria, a high atom efficiency nanoplatform, Mn/HA-CDs, made from hyaluronic acid-derived carbon dots (HA-CDs) and Mn2+ in a coordination structure of Mn-N5. We found that the Mn/HA-CDs with atomically dispersed Mn (0.73%) can generate reactive oxygen species (ROS) with a high atom economy. Particularly, its singlet oxygen (1O2) quantum yield (0.40) is 3 times higher than that of the previous HA-CDs (0.13). Active absorption of Mn/HA-CDs by mitochondria inhibits mitochondrial superoxide dismutase (SOD) enzyme function, intensifies ROS damage to the mitochondria, and eventually promotes the photodynamic therapy (PDT) effect on tumor cells. Our findings suggest that targeting mitochondria with single-atom metal-anchored CDs for a better PDT effect is a viable method of treating tumors.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Carbon and Quantum Dots Applications · Advanced Nanomaterials in Catalysis · Nanocluster Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, China
National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
Department of Chemistry, Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo 14040-901, Brazil
School of Materials Science and Engineering, Anhui University, Hefei 230601, China
Funding
Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Anhui Provincial Key Research and Development Plan · Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education · Key Laboratory of Environment-Friendly Polymer Materials of Anhui Province · Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province
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