journal article·2026-04

Spin-mediated and proton-coupled electron transfer boost NADH oxidase-like activity of dual-atom metallozymes

Jiarong Li, Yonghui Li, Zhen Wan, Hongyang Li, Haitao Dai, Changlong Liu, Xiaoyu Mu, Xiao-Dong Zhang

Nano Today· Volume 68
Publisher page

Abstract

No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.

Source: Not provided · Quality: missing

Research context

OpenAlex topics: Advanced Nanomaterials in Catalysis · Metal-Catalyzed Oxygenation Mechanisms · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (61)

Show source-provided references
1. NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus10.1016/j.cmet.2015.05.023 ↗
2. NAD+ metabolism governs the proinflammatory senescence-associated secretome10.1038/s41556-019-0287-4 ↗
3. NAD+ in aging, metabolism, and neurodegeneration10.1126/science.aac4854 ↗
4. Engineering oxygen-independent NADH oxidase integrated with electrocatalytic FAD cofactor regeneration10.1021/jacsau.4c00528 ↗
5. The dynamic regulation of NAD metabolism in mitochondria10.1016/j.tem.2012.06.005 ↗
6. NADH oxidase from Lactobacillus reuteri: a versatile enzyme for oxidized cofactor regeneration10.1016/j.ijbiomac.2018.11.096 ↗
7. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)10.1039/C8CS00457A ↗
8. An anaerobic biomimetic metal-free AIE polymersome nanozyme as NADH oxidase mimic for photocatalytic tumor suppression by impairing cancer cell energy metabolism under hypoxia10.1021/jacs.5c06533 ↗
9. Mated-atom nanozymes with efficient assisted NAD+ replenishment for skin regeneration
10. LUMO-mediated Se and HOMO-mediated Te nanozymes for selective redox biocatalysis10.1021/acs.nanolett.3c01068 ↗
11. An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury10.1126/sciadv.abk1210 ↗
12. Unraveling the proximity effects of a Co–P dual site in phosphorus-coordinated cobalt single-atom nanozymes10.1021/acsnano.5c18031 ↗
13. Regulating the N coordination environment of Co single-atom nanozymes for highly efficient oxidase mimics10.1021/acs.nanolett.2c04944 ↗
14. Reactive high-spin iron(IV)-oxo sites through dioxygen activation in a metal–organic framework10.1126/science.add7417 ↗
15. Regulating Fe-spin state by atomically dispersed Mn-N in Fe-N-C catalysts with high oxygen reduction activity10.1038/s41467-021-21919-5 ↗
16. Engineering spin state of atomic iron centers for high-performance photocatalytic nitrogen fixation10.1002/anie.202506470 ↗
17. Boosting electrocatalytic nitrogen reduction on cobalt-based perovskite via regulating reaction pathway through donation-back-donation modulation
18. Spin tunnel field-effect transistors based on two-dimensional van der Waals heterostructures10.1038/s41928-019-0232-3 ↗
19. Spin engineering of Fe─N─C by axial ligand modulation for enhanced bifunctional oxygen catalysis10.1002/adfm.202409794 ↗
20. A new strategy to efficiently cleave and form C–H bonds using proton-coupled electron transfer10.1126/sciadv.aat5776 ↗
21. Proton-coupled electron transfer controls peroxide activation initiated by a solid-water interface10.1038/s41467-025-58917-w ↗
22. The role of Tyr34 in proton coupled electron transfer and product inhibition of manganese superoxide dismutase10.1038/s41467-025-57180-3 ↗
23. Exchange coupling states of cobalt complexes to control proton-coupled electron transfer10.1038/s41467-024-53099-3 ↗
24. Use of a PCET mediator enables a Ni-HER electrocatalyst to act as a hydride delivery agent10.1021/jacs.2c09786 ↗
25. Coordination induced spin state transition switches the reactivity of nickel (II) porphyrin in hydrogen evolution reaction10.1002/anie.202413042 ↗
26. Proton-inducedswitching of paramagnetism: reversible conversion between a low and high spin CoIII center within a heterobimetallic core10.1021/jacs.4c12327 ↗
27. Development of an FeII complex exhibiting intermolecular proton shifting coupled spin transition10.1002/anie.202404843 ↗
28. Proton-coupled electron transfer at the Pu5+/4+ couple10.1021/jacs.4c06319 ↗
29. Peroxide-driven nitrogen fixation reactions for energy storage applications10.1002/aenm.202501583 ↗
30. Stabilizing atomic Ru species in conjugated sp2 carbon-linked covalent organic framework for acidic water oxidation10.1038/s41467-024-49834-5 ↗
31. Enhanced degradation and recycling of reactive dye wastewater using cobalt loaded MXene catalysts10.1038/s41545-024-00391-w ↗
32. How to correctly analyze 2p X-ray photoelectron spectra of 3d transition-metal oxides: pitfalls and principles10.1021/acsnano.4c03964 ↗
33. Unexpected activity of MgO nanoclusters for the reductive-coupling synthesis of organonitrogen chemicals with C = N bonds10.1038/s41467-025-58222-6 ↗
34. Enhancing zinc–air battery performance by constructing three-dimensional N-doped carbon coating multiple valence Co and MnO heterostructures10.1007/s12274-023-6404-5 ↗
35. Iron-single-atom nanozyme with NIR enhanced catalytic activities for facilitating MRSA-infected wound therapy
36. Regulating the spin state of FeIII by atomically anchoring on ultrathin titanium dioxide for efficient oxygen evolution electrocatalysis10.1002/anie.201913080 ↗
37. Engineering electrocatalytic activity in nanosized perovskite cobaltite through surface spin-state transition10.1038/ncomms11510 ↗
38. Tuning the spin state of the iron center by bridge-bonded Fe-O-Ti ligands for enhanced oxygen reduction
39. Tailoring atomic strain environment for high-performance acidic oxygen reduction by Fe-Ru dual atoms communicative effect10.1016/j.matt.2024.01.019 ↗
40. Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma10.1038/s41467-022-32411-z ↗
41. Molecular switching by proton-coupled electron transport drives giant negative differential resistance10.1038/s41467-024-52496-y ↗
42. Coenzyme-dependent nanozymes playing dual roles in oxidase and reductase mimics with enhanced electron transport10.1039/D0NR06605B ↗
43. A Hemin/G-quadruplex acts as an NADH oxidase and NADH peroxidase mimicking DNAzyme10.1002/anie.201103853 ↗
44. Platinum nanoparticle-deposited multi-walled carbon nanotubes as a NADH oxidase mimic: characterization and applications10.1039/D0NR04060F ↗
45. Versatile three-dimensional porous Cu@Cu2O aerogel networks as electrocatalysts and mimicking peroxidases10.1002/anie.201801369 ↗
46. Cadmium sulfide as bifunctional mimics of NADH oxidase and cytochrome c reductase takes effect at physiological pH10.1007/s12274-022-4150-8 ↗
47. Ru(III)-based metal–organic gels: Intrinsic horseradish and NADH peroxidase-mimicking nanozyme10.1021/acsami.9b09283 ↗
48. New biotechnological perspectives of a NADH oxidase variant from Thermus thermophilus HB27 as NAD+-recycling enzyme10.1186/1472-6750-11-101 ↗
49. Structural basis for double cofactor specificity in a new formate dehydrogenase from the acidobacterium Granulicella mallensis MP5ACTX810.1007/s00253-015-6695-x ↗
50. DMSO tolerant NAD(P)H recycler enzyme from a pathogenic bacterium, Burkholderia dolosa PC543: effect of N-/C-terminal His Tag extension on protein solubility and activity10.1002/elsc.201800036 ↗
51. Discovery of an acidic, thermostable and highly NADP+ dependent formate dehydrogenase from Lactobacillus buchneri NRRL B-3092910.1007/s10529-018-2568-6 ↗
52. Purification and characterization of an H2O-forming NADH oxidase from Clostridium aminovalericum: Existence of an oxygen-detoxifying enzyme in an obligate anaerobic bacteria10.1007/s00203-004-0659-3 ↗
53. Isolation and biochemical characterization of a new NADH oxidase from Lactobacillus brevis10.1023/A:1021730131633 ↗
54. Cofactor regeneration of NAD+ from NADH: Novel water-forming NADH oxidases10.1002/1615-4169(200212)344:10<1156::AID-ADSC1156>3.0.CO;2-# ↗
55. Characterization of H2O-forming NADH oxidase from Streptococcus pyogenes and its application in l-rare sugar production10.1016/j.bmcl.2012.01.049 ↗
56. Characterization of the Streptococcus pneumoniae NADH oxidase that is required for infection10.1099/00221287-147-2-431 ↗
57. Identification of two distinct NADH oxidases corresponding to H2O2-forming oxidase and H2O-forming oxidase induced in Streptococcus mutans
58. Purification and characterization of NADH oxidase from Serpulina (Treponema) hyodysenteriae10.1128/jb.175.10.2980-2987.1993 ↗
59. Atomic-scale strain engineering of atomically resolved Pt clusters transcending natural enzymes10.1038/s41467-024-52684-w ↗
60. Lung cancer-associated mesenchymal stem cells mediate chemoresistance and malignant progression of lung cancer through activating HIF-1α10.22203/eCM.v050a06 ↗
61. Targeted alleviation of ischemic stroke reperfusion via atorvastatin-ferritin Gd-layered double hydroxide