journal article·2026-02

Advanced strategies for extending the blood circulation time of nano-based delivery systems

Mohammad Reza Kandi, Amir Zarebkohan, Donya Shaterabadi, Roya Salehi, Babak Negahdari, Michael R. Hamblin

Nano Today· Volume 67
Publisher page

Abstract

No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.

Source: Not provided · Quality: missing

Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (100+)

Show source-provided references
1. Clinical cancer nanomedicines10.1016/j.jconrel.2025.113991 ↗
2. Rational design of cancer nanomedicine: nanoproperty integration and synchronization10.1002/adma.201606628 ↗
3. Why nanoparticles prefer liver macrophage cell uptake in vivo10.1016/j.addr.2022.114238 ↗
4. Analysis of nanoparticle delivery to tumours10.1038/natrevmats.2016.14 ↗
5. Long-circulating and target-specific nanoparticles: theory to practice10.1016/S0031-6997(24)01494-7 ↗
6. Factors that control the circulation time of nanoparticles in blood: challenges, solutions and future prospects10.2174/138161210791920496 ↗
7. Beyond PEGylation: nanoparticle surface modulation for enhanced cancer therapy10.1186/s44301-025-00014-4 ↗
8. W. Bao, F. Tian, C. Lyu, B. Liu, B. Li, L. Zhang, X. Liu, F. Li, D. Li, X. Gao, S. Wang, W. Wei, X. Shi, Y. Li, Experimental and theoretical explorations of nanocarriers’ multistep delivery performance for rational design and anticancer prediction, Science Advances 7 (n.d.) eaba2458. https://doi.org/10.1126/sciadv.aba2458.10.1126/sciadv.aba2458 ↗
9. The ancillary effects of nanoparticles and their implications for nanomedicine10.1038/s41565-021-01017-9 ↗
10. Personalized protein corona on nanoparticles and its clinical implications10.1039/C6BM00921B ↗
11. Precision nanomedicine development based on specific opsonization of human cancer patient-personalized protein coronas10.1021/acs.nanolett.9b01774 ↗
12. Nanoparticle uptake: the phagocyte problem10.1016/j.nantod.2015.06.006 ↗
13. Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein AI in corona formation10.1038/s41467-022-31882-4 ↗
14. Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles10.1038/s41565-018-0344-3 ↗
15. Engineering long-circulating nanomaterial delivery systems10.1016/j.copbio.2020.07.006 ↗
16. A brief history of long circulating nanoparticles10.1016/j.addr.2022.114396 ↗
17. Irina MuljajewStealth Effect of Short Polyoxazolines in Graft Copolymers: Minor Changes of Backbone End Group Determine Liver Cell-Type Specificity, (n.d.).
18. Metabolism of nanomaterials in vivo: blood circulation and organ clearance10.1021/ar2003336 ↗
19. Tissue-specific macrophages: how they develop and choreograph tissue biology10.1038/s41577-023-00848-y ↗
20. Bioinert, stealth or interactive: how surface chemistry of nanocarriers determines their fate in vivo10.1002/adfm.202103347 ↗
21. Stealth nanoparticles in oncology: Facing the PEG dilemma10.1016/j.jconrel.2022.09.002 ↗
22. Branched PEG-modification: a new strategy for nanocarriers to evade of the accelerated blood clearance phenomenon and enhance anti-tumor efficacy10.1016/j.biomaterials.2022.121415 ↗
23. Inherent anti-HIV activity of biocompatible anionic citrate-PEG-citrate dendrimer10.1007/s11033-018-4455-6 ↗
24. Conjugated anionic PEG-citrate G2 dendrimer with multi-epitopic HIV-1 vaccine candidate enhance the cellular immune responses in mice10.1080/21691401.2017.1290642 ↗
25. To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives10.1016/j.addr.2021.114079 ↗
26. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes10.1016/0014-5793(90)81016-H ↗
27. Polymeric micelles with α-glutamyl-terminated PEG shells show low non-specific protein adsorption and a prolonged in vivo circulation time10.1016/j.msec.2015.10.084 ↗
28. Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)10.1038/s41467-020-19947-8 ↗
29. Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics10.1038/s41467-017-00600-w ↗
30. Dense and dynamic polyethylene glycol shells cloak nanoparticles from uptake by liver endothelial cells for long blood circulation10.1021/acsnano.8b04947 ↗
31. Bing-Mae Chen 2021, Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies, (n.d.).10.1021/acsnano.1c05922 ↗
32. Alternating stealth polymer coatings between administrations minimizes toxic and antibody immune responses towards nanomedicine treatment regimens10.1016/j.actbio.2020.11.047 ↗
33. Effects of cleavable PEG-cholesterol derivatives on the accelerated blood clearance of PEGylated liposomes10.1016/j.biomaterials.2010.02.049 ↗
34. Collagenase IV and clusterin-modified polycaprolactone-polyethylene glycol nanoparticles for penetrating dense tumor tissues10.7150/thno.47446 ↗
35. Sensing surface PEGylation with microcantilevers10.3762/bjnano.1.2 ↗
36. Brush conformation of polyethylene glycol determines the stealth effect of nanocarriers in the low protein adsorption regime10.1021/acs.nanolett.0c03756 ↗
37. Surface hydration: principles and applications toward low-fouling/nonfouling biomaterials10.1016/j.polymer.2010.08.022 ↗
38. Beyond Poly(ethylene glycol): linear polyglycerol as a multifunctional polyether for biomedical and pharmaceutical applications10.1021/bm5002608 ↗
39. Self-assembled monothiol-terminated hyperbranched polyglycerols on a gold surface: a comparative study on the structure, morphology, and protein adsorption characteristics with linear poly(ethylene glycol)s10.1021/la702867t ↗
40. Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface10.1038/s41467-020-16772-x ↗
41. The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles10.1016/j.biomaterials.2014.04.038 ↗
42. Polyglycerol and Poly(ethylene glycol) exhibit different effects on pharmacokinetics and antibody generation when grafted to nanoparticle surfaces10.1016/j.biomaterials.2022.121676 ↗
43. Poly(2-ethyl-2-oxazoline) (POx) as Poly(ethylene glycol) (PEG)-Lipid Substitute for Lipid Nanoparticle Formulations10.1002/smll.202411354 ↗
44. Poly(2-ethyl-2-oxazoline) as Alternative for the Stealth Polymer Poly(ethylene glycol): Comparison of in vitro Cytotoxicity and Hemocompatibility10.1002/mabi.201200017 ↗
45. Tuning the surface of nanoparticles: impact of poly(2-ethyl-2-oxazoline) on protein adsorption in serum and cellular uptake10.1002/mabi.201600074 ↗
46. Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline)10.1039/C8NR00835C ↗
47. Synthesis, biodistribution and excretion of radiolabeled poly(2-alkyl-2-oxazoline)s10.1016/j.jconrel.2007.02.015 ↗
48. Clinical development of a poly(2-oxazoline) (POZ) polymer therapeutic for the treatment of Parkinson’s disease – Proof of concept of POZ as a versatile polymer platform for drug development in multiple therapeutic indications10.1016/j.eurpolymj.2016.09.052 ↗
49. PEGylation technology: addressing concerns, moving forward10.1080/10717544.2025.2494775 ↗
50. Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs10.1016/j.csbj.2020.07.015 ↗
51. Rational design of cancer nanomedicine for simultaneous stealth surface and enhanced cellular uptake
52. Size-dependent EPR effect of polymeric nanoparticles on tumor targeting10.1002/adhm.201901223 ↗
53. Progress in biodegradable zwitterionic materials10.1016/j.polymdegradstab.2017.03.015 ↗
54. Doxorubicin conjugated phospholipid prodrugs as smart nanomedicine platforms for cancer therapy10.1039/C4TB01984A ↗
55. Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior10.1016/j.biomaterials.2014.11.010 ↗
56. Hydrolytically Degradable Zwitterionic Polyphosphazene Containing HEPES Moieties as Side Groups10.1021/acs.biomac.4c01008 ↗
57. Blood retention and antigenicity of polycarboxybetaine-modified liposomes10.1016/j.ijpharm.2020.119521 ↗
58. Superhydrophilic zwitterionic polymers stabilize liposomes10.1021/la302433a ↗
59. Polycarboxybetaine in advanced drug delivery systems: From structure-function relationship to therapeutic applications
60. Zwitterionic stealth peptide-protected gold nanoparticles enable long circulation without the accelerated blood clearance phenomenon10.1039/C7BM00747G ↗
61. The role of sex as a biological variable in the efficacy and toxicity of therapeutic nanomedicine10.1016/j.addr.2021.04.028 ↗
62. Design of smart size-, surface-, and shape-switching nanoparticles to improve therapeutic efficacy
63. When imaging meets size-transformable nanosystems10.1016/j.addr.2022.114176 ↗
64. Hypoxia-Targeting, Tumor Microenvironment Responsive Nanocluster Bomb for Radical-Enhanced Radiotherapy10.1021/acsnano.7b04737 ↗
65. A near-infrared light-responsive extracellular vesicle as a “Trojan horse” for tumor deep penetration and imaging-guided therapy10.1016/j.biomaterials.2020.120647 ↗
66. Nanoparticles with transformable physicochemical properties for overcoming biological barriers10.1039/D3NR01332D ↗
67. Dual pH/redox-responsive hyperbranched polymeric nanocarriers with TME-trigger size shrinkage and charge reversible ability for amplified chemotherapy of breast cancer10.1038/s41598-024-57296-4 ↗
68. Tumor Microenvironment-Responsive Nanoshuttles with Sodium Citrate Modification for Hierarchical Targeting and Improved Tumor Theranostics10.1021/acsami.9b07957 ↗
69. Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy10.1038/s41565-019-0485-z ↗
70. Shape switching of CaCO3-templated nanorods into stiffness-adjustable nanocapsules to promote efficient drug delivery10.1016/j.actbio.2021.04.011 ↗
71. Stiffness-transformable nanoplatforms responsive to the tumor microenvironment for enhanced tumor therapeutic efficacy10.1002/anie.202216361 ↗
72. Switchable PAMAM megamers for deep tumor penetration and enhanced cell uptake10.1016/j.jconrel.2024.09.031 ↗
73. Overcoming the Reticuloendothelial System Barrier to Drug Delivery with a “Don’t-Eat-Us” Strategy10.1021/acsnano.9b05679 ↗
74. Effect of removing Kupffer cells on nanoparticle tumor delivery10.1073/pnas.1713390114 ↗
75. Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery10.1038/s41467-024-48838-5 ↗
76. Fucoidan prolongs the circulation time of dextran-coated iron oxide nanoparticles10.1021/acsnano.7b06734 ↗
77. Regulating interactions between targeted nanocarriers and mononuclear phagocyte system via an esomeprazole-based preconditioning strategy10.2147/IJN.S258054 ↗
78. Boosting nanomedicine performance by conditioning macrophages with methyl palmitate nanoparticles10.1039/D1MH00937K ↗
79. Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines10.1126/sciadv.abb8133 ↗
81. The dose threshold for nanoparticle tumour delivery10.1038/s41563-020-0755-z ↗
82. RES blockade: A strategy for boosting efficiency of nanoparticle drug10.1016/j.nantod.2014.12.003 ↗
83. Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes10.1038/s41551-020-0581-2 ↗
84. Toward Understanding in Vivo Sequestration of Nanoparticles at the Molecular Level10.1021/acsnano.8b00141 ↗
85. Extracellular vesicles for the delivery of gene therapy10.1038/s44222-025-00277-7 ↗
86. Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium10.7150/thno.38198 ↗
87. Activation of the complement system by nanoparticles and strategies for complement inhibition10.1016/j.ejpb.2023.11.006 ↗
88. Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions10.1016/j.jconrel.2023.02.022 ↗
89. Biomaterial design for proactive modulation of the complement system10.1038/s44222-025-00281-x ↗
90. Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins10.1038/s41565-023-01514-z ↗
91. Overcoming Hepatic Biotransformation Barrier of Gold Nanoparticles via Au–Se Bond for Enhanced In Vivo Active Targeting10.1021/acsnano.4c10700 ↗
92. pH/redox responsive size-switchable intelligent nanovehicle for tumor microenvironment targeted DOX release10.1038/s41598-023-49446-x ↗
93. Impact of glutathione modulation on stability and pharmacokinetic profile of redox-sensitive nanogels10.1002/smll.201704093 ↗
94. Controlling the biodistribution and clearance of nanomedicines10.1038/s44222-023-00138-1 ↗
95. Glutathione-mediated biotransformation in the liver modulates nanoparticle transport10.1038/s41565-019-0499-6 ↗
96. Quantitative Analysis of Protein Corona on Precoated Protein Nanoparticles and Determined Nanoparticles with Ultralow Protein Corona and Efficient Targeting in Vivo10.1021/acsami.1c12008 ↗
97. In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?10.1039/D0NA00863J ↗
98. Phosphatidylcholine-Coated Iron Oxide Nanomicelles for In Vivo Prolonged Circulation Time with an Antibiofouling Protein Corona10.1002/chem.201404221 ↗
99. Photothermal effect of albumin-modified gold nanorods diminished neuroblastoma cancer stem cells dynamic growth by modulating autophagy10.1038/s41598-022-15660-2 ↗
100. The effects of protein corona on in vivo fate of nanocarriers10.1016/j.addr.2022.114356 ↗