journal article·2026-02

Size dependent nephrotoxicity of polystyrene microplastics revealed by single-cell transcriptomics profiling

Chen Wang, Tong Yang, Xueling He, Cui Liu, Ang Ma, Chao Chen, Yunmeng Bai, Huiying Li, Peng Gao, Lirun Zhou, Da Chen, Jigang Wang, Huan Tang

Nano Today· Volume 66
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OpenAlex topics: Microplastics and Plastic Pollution · Effects and risks of endocrine disrupting chemicals · Nanoparticles: synthesis and applications

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References (44)

Show source-provided references
1. Lost at sea: where is all the plastic?10.1126/science.1094559 ↗
2. Environmental microplastics: classification, sources, fates, and effects on plants10.1016/j.chemosphere.2022.137559 ↗
3. Microplastics: finding a consensus on the definition10.1016/j.marpolbul.2018.11.022 ↗
4. Microplastics and nanoplastics: source, behavior, remediation, and multi-level environmental impact10.1016/j.jenvman.2024.120618 ↗
5. A catchment-scale perspective of plastic pollution10.1111/gcb.14572 ↗
6. Microplastics in the human body: a comprehensive review of exposure, distribution, migration mechanisms, and toxicity10.1016/j.scitotenv.2024.174215 ↗
7. Detection of microplastics in human tissues and organs: a scoping review10.7189/jogh.14.04179 ↗
8. Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: an in-depth quantitative analysis10.1016/j.nantod.2024.102466 ↗
9. Quantifying the trophic transfer of sub-micron plastics in an assembled food chain10.1016/j.nantod.2022.101611 ↗
10. Effects of microplastics on the kidneys: a narrative review10.1016/j.kint.2024.05.023 ↗
11. Microplastics and kidneys: an update on the evidence for deposition of plastic microparticles in human organs, tissues and fluids and renal toxicity concern10.3390/ijms241814391 ↗
12. Microplastics exposure disrupts nephrogenesis and induces renal toxicity in human iPSC-derived kidney organoids10.1016/j.envpol.2024.124645 ↗
13. The kidney-related effects of polystyrene microplastics on human kidney proximal tubular epithelial cells HK-2 and Male C57BL/6 mice10.1289/EHP7612 ↗
14. Microplastics exacerbate cadmium-induced kidney injury by enhancing oxidative stress, autophagy, apoptosis, and fibrosis10.3390/ijms232214411 ↗
15. The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction10.2217/nnm.16.5 ↗
16. Beyond the promise: exploring the complex interactions of nanoparticles within biological systems10.1016/j.jhazmat.2024.133800 ↗
17. Nano-bio interactions: the implication of size-dependent biological effects of nanomaterials10.1007/s11427-020-1725-0 ↗
18. Polystyrene nanoplastics induce intestinal and hepatic inflammation through activation of NF-kappaB/NLRP3 pathways and related gut-liver axis in mice10.1016/j.scitotenv.2024.173458 ↗
19. Effects of nano- and microplastics on kidney: physicochemical properties, bioaccumulation, oxidative stress and immunoreaction
20. Single-cell RNA sequencing technologies and applications: a brief overview10.1002/ctm2.694 ↗
21. Emerging clinical applications of single-cell RNA sequencing in oncology10.1038/s41571-025-01003-3 ↗
22. A single-cell atlas of bisphenol A (BPA)-induced testicular injury in mice10.1002/ctm2.789 ↗
23. Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice
24. New molecular-scale information on polystyrene dynamics in PS and PS-BaTiO3 composites from FTIR spectroscopy10.1039/C4CP03516J ↗
25. Kidney Injury Molecule 1 (KIM-1): a multifunctional glycoprotein and biological marker (Review)10.17691/stm2021.13.3.08 ↗
26. Kidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients10.1681/ASN.2020070930 ↗
27. Prediction of cellular targets in diabetic kidney diseases with single-cell transcriptomic analysis of db/db mouse kidneys10.1007/s12079-022-00685-z ↗
28. The STAT1/HMGB1/NF-kappaB pathway in chronic inflammation and kidney injury after cisplatin exposure10.7150/thno.81406 ↗
29. Policy: Classify plastic waste as hazardous10.1038/494169a ↗
30. Cisplatin nephrotoxicity: new insights and therapeutic implications10.1038/s41581-022-00631-7 ↗
31. Arbutin attenuates LPS-induced acute kidney injury by inhibiting inflammation and apoptosis via the PI3K/Akt/Nrf2 pathway10.1016/j.phymed.2021.153466 ↗
32. The nephrotoxic potential of polystyrene microplastics at realistic environmental concentrations10.1016/j.jhazmat.2021.127871 ↗
33. Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy10.1172/jci.insight.157360 ↗
34. Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease10.1038/s41419-023-06185-1 ↗
35. Single-cell transcriptome analysis of liver immune microenvironment changes induced by microplastics in mice with non-alcoholic fatty liver
36. Oxidative stress and mitochondrial dysfunction in chronic kidney disease10.3390/cells12010088 ↗
37. Oxidative stress in the pathophysiology of kidney disease: implications for noninvasive monitoring and identification of biomarkers10.1155/2020/5478708 ↗
38. Crosstalk of reactive oxygen species and NF-kappaB signaling10.1038/cr.2010.178 ↗
39. TNF and ROS Crosstalk in Inflammation10.1016/j.tcb.2015.12.002 ↗
40. The microplastics exposure induce the kidney injury in mice revealed by RNA-seq10.1016/j.ecoenv.2023.114821 ↗
41. Microplastics induce human kidney development retardation through ATP-mediated glucose metabolism rewiring10.1016/j.jhazmat.2024.137002 ↗
42. Environmental nanoplastics induce mitochondrial dysfunction: a review of cellular mechanisms and associated diseases10.1016/j.envpol.2025.126695 ↗
43. Polystyrene microplastics induce size-dependent multi-organ damage in mice: Insights into gut microbiota and fecal metabolites10.1016/j.jhazmat.2023.132503 ↗
44. Microplastics and environmental pollutants: Key interaction and toxicology in aquatic and soil environments10.1016/j.jhazmat.2021.126843 ↗