Au4 cluster inhibits human thioredoxin reductase activity via specifically binding of Au to Cys189
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OpenAlex topics: Trace Elements in Health · Advanced Nanomaterials in Catalysis · Nanocluster Synthesis and Applications
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References (28)
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1. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy10.1126/scitranslmed.aaf7444 ↗
2. Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against Chronic Lymphocytic Leukemia10.1158/0008-5472.CAN-13-2033 ↗
3. The gold complex auranofin: new perspectives for cancer therapy10.1007/s12672-021-00439-0 ↗
4. Au nanoclusters suppress chronic lymphocytic leukaemia cells by inhibiting thioredoxin reductase 1 to induce intracellular oxidative stress and apoptosis10.1016/j.scib.2017.03.024 ↗
5. Crystal structure of the human thioredoxin reductase–thioredoxin complex10.1038/ncomms1382 ↗
6. Why nature chose selenium10.1021/acschembio.6b00031 ↗
7. Update on selenoprotein biosynthesis10.1089/ars.2015.6391 ↗
8. Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence10.1073/pnas.100114897 ↗
9. Targeting the thioredoxin system for cancer therapy10.1016/j.tips.2017.06.001 ↗
10. Bifunctional peptides that precisely biomineralize Au clusters and specifically stain cell nuclei10.1039/C1CC15926G ↗
11. Ultrasmall Au nanoclusters for biomedical and biosensing applications: a mini-review10.1016/j.talanta.2019.03.068 ↗
12. Controlling endosomal escape using nanoparticle composition: current progress and future perspectives10.2217/nnm-2018-0326 ↗
13. The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis10.1016/j.jmb.2007.04.044 ↗
14. Crystal structure and catalysis of the selenoprotein thioredoxin reductase 110.1074/jbc.M807068200 ↗
15. Crystal structure of the Plasmodium falciparum thioredoxin reductase-thioredoxin complex10.1016/j.jmb.2013.06.037 ↗
16. Transduction of redox signaling by electrophile-protein reactions10.1126/scisignal.290re7 ↗
17. Three-dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine-dependent enzyme10.1073/pnas.171178698 ↗
18. Thioredoxin reductase as a novel molecular target for cancer therapy10.1016/j.canlet.2005.04.028 ↗
19. Thioredoxin reductase as a pathophysiological factor and drug target10.1046/j.1432-1327.2000.01703.x ↗
20. Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity
21. Organic arsenicals target thioredoxin reductase followed by oxidative stress and mitochondrial dysfunction resulting in apoptosis10.1016/j.ejmech.2017.05.022 ↗
22. Au-24 as a potential thioredoxin reductase inhibitor in hepatocellular carcinoma cells10.1016/j.phrs.2022.106113 ↗
23. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade10.1016/S0092-8674(00)80434-1 ↗
24. Apoptosomes: engines for caspase activation10.1016/S0955-0674(02)00381-2 ↗
25. The apoptosome: signalling platform of cell death10.1038/nrm2153 ↗
26. Cloning and characterization of rat caspase-9: Implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia10.1097/00004647-200205000-00005 ↗
27. Baicalein protects Human melanocytes from H2O2-induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38 MAPK pathway10.1016/j.freeradbiomed.2012.04.015 ↗
28. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -710.1021/bi001603q ↗