Unveiling the biological applications of biosynthesized magnesium oxide-manganese oxide-gold ternary nanocomposite (MgO–MnO–Au TNC) by Mangifera indica peel: characterization, antimicrobial, antioxidant and anticancer activities
Source abstract
Abstract
Abstract In the current study, a magnesium oxide–manganese oxide–gold ternary nanocomposite (MgO–MnO–Au TNC) was biosynthesized using Mangifera indica peel extract through an eco-friendly, one-pot approach. UV–visible spectroscopy confirmed the presence of MgO, MnO, and Au within the ternary nanocomposite, showing two absorption bands corresponding to the combined optical effects of the components, while DLS and TEM analysis showed an average particle size of approximately 120 nm with a spherical morphology. XRD analysis demonstrated distinct crystalline peaks corresponding to MgO, MnO, and Au, affirming the polycrystalline nature of the TNC. Biological evaluations demonstrated that MgO–MnO–Au TNC exhibited broad-spectrum antibacterial activity, with MIC values of 62.5 μg/mL against Pseudomonas aeruginosa and 250 μg/mL against Staphylococcus aureus . Antioxidant activity was also remarkable, with IC 50 values of 149.6 μg/mL (DPPH) and 242.1 μg/mL (APTS). Cytotoxicity assessment revealed an IC 50 of 193 μg/mL against normal Wi-38 cells, whereas MCF-7 and Hep-G2 cancer cell lines exhibited IC 50 values of 26.43 μg/mL and 84.13 μg/mL, respectively, indicating selective cytotoxicity with selectivity indices of 7.32 (MCF-7) and 2.30 (Hep-G2). In conclusion, these findings suggest that MgO–MnO–Au TNC is a promising candidate for antimicrobial, antioxidant, and anticancer applications, warranting further investigation into its underlying mechanisms and therapeutic potential.
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Research context
OpenAlex topics: Magnesium Oxide Properties and Applications · Nanoparticles: synthesis and applications · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences , Jouf University , Sakaka 72388 , Saudi Arabia
College of Pharmacy , Al-Farahidi University , Baghdad , Iraq
Botany and Microbiology Department, Faculty of Science , Al-Azhar University , Cairo P.O. Box 11884 , Egypt
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences , King Abdulaziz University , Jeddah , Saudi Arabia
Special Infectious Agents Unit, King Fahad Medical Research Center, King AbdulAziz University , Jeddah , Saudi Arabia
Department of Clinical Microbiology and Immunology, College of Medicine , King AbdulAziz University , Jeddah , Saudi Arabia
Department of Basic Medical Sciences, College of Medicine , University of Jeddah , Jeddah , Saudi Arabia
Department of Biology, College of Science , Taibah University , Al Madinah 42353 , Saudi Arabia
Department of Biology, College of Science , Jazan University , P.O. Box 114 , Jazan 45142 , Saudi Arabia
Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology , University of Vienna , Vienna 1090 , Austria
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