Durian husk-mediated green synthesis of Cr 2 O 3 nanoparticles exhibiting uncompetitive inhibition of pancreatic lipase for anti-obesity applications
Source abstract
Abstract
Abstract The global obesity epidemic underscores the urgent need for safer and more sustainable alternatives to conventional lipase inhibitors, which are limited by adverse side effects. In this study, chromium oxide nanoparticles (Cr 2 O 3 NPs) were synthesized via a microwave-assisted green route using durian ( Durio zibethinus or D. zibethinus ) husk extract (DHE), valorising agricultural waste as a natural reducing and stabilising agent. The nanoparticles were comprehensively characterised, confirming a rhombohedral eskolaite crystalline structure, quasi-spherical morphology with an average size of 65.93 ± 13.48 nm, and a bandgap energy of 3.32 eV. Functionally, the Cr 2 O 3 NPs exhibited strong antioxidant activity (91.94 % DPPH, 57.0 % ABTS) and significant pancreatic lipase inhibition (73.82 %). Kinetic analysis revealed an uncompetitive inhibition mechanism, representing the first report of durian husk-derived Cr 2 O 3 NPs with this enzymatic action. These findings highlight the dual antioxidant and enzymatic inhibitory potential of green-synthesised Cr 2 O 3 NPs and their promise as sustainable nanotherapeutics for obesity management within the framework of green nanomedicine and circular bioeconomy.
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Research context
OpenAlex topics: Pigment Synthesis and Properties · Nanoparticles: synthesis and applications · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical Science, Faculty of Science , Universiti Tunku Abdul Rahman (UTAR), Kampar Campus, Jalan Universiti , Kampar , 31900 , Malaysia
Department of Natural Sciences, Faculty of Science , BGMEA University of Fashion & Technology (BUFT), Nishatnagar, Turag , Dhaka , 1230 , Bangladesh
Department of Biological Science, Faculty of Science , Universiti Tunku Abdul Rahman (UTAR), Kampar Campus, Jalan Universiti , Kampar , 31900 , Malaysia
Department of Chemistry , National Sun Yat-Sen University , Kaohsiung , 80424 , Taiwan
Faculty of Health and Life Sciences , INTI International University , Nilai , 71800 , Negeri Sembilan , Malaysia
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