Wound healing activities of sulfur nanoparticles of Allium cepa extract embedded in a nanocream formulation: in vitro and in vivo studies
Source abstract
Abstract
Abstract This research was aimed to prepare sulfur nanoparticles (SNPs) using Allium cepa extract and use them in nanocream. Characterization of the SNPs included measurements of zeta size, zeta potential, UV analyses, ATR-FTIR analyses, and SEM analyses. SNPs were tested for antibacterial and antifungal properties. An excision wound model was used to assess SNP-loaded nanocream activities on wound healing. Particle diameter was 125.21 ± 1.54 nm, and PDI was 0.278 ± 0.02 mV, whereas the zeta potential was −14.16 ± 0.54 mV. ATR-FTIR analysis showed that A. cepa extract, SNPs, and nanocream are compatible with each other and their chemical composition does not change. The SNPs were homogeneous and almost round in shape with a diameter of 125 nm. The incorporation of A. cepa SNPs with antibiotics has been shown to be statistically significant against Staphylococcus aureus , Bacillus subtilis , Escherichia coli , Bordetella , and Candida albicans resistance. The nanocream containing SNPs was homogeneous, had a skin-compatible pH value, viscosity, and spreadability. Nanocream showed increased wound healing properties and was not irritating to the skin. A green synthesis of SNPs is effective in promoting antibacterial, antifungal, and wound healing properties.
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Research context
OpenAlex topics: Structural mechanics and materials · Garlic and Onion Studies · Wound Healing and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Gomal Centre of Biochemistry and Biotechnology , Gomal University , Dera Ismail Khan , 29050 Khyber Pakhtunkhwa , Pakistan
Department of Pharmaceutical Technology, Faculty of Pharmacy , Universiti Malaya , 50603 Kuala Lumpur , Malaysia
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy , Gomal University , Dera Ismail Khan 29050 Khyber Pakhtunkhwa , Pakistan
Department of Clinical Laboratories Sciences, College of Applied Medical Sciences , Taif University , P.O. Box 11099 , Taif 21944 , Saudi Arabia
Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia , Bangi 43600 , Selangor , Malaysia
Faculty of Pharmacy , University College of MAIWP International , Batu Caves 68100 , Kuala Lumpur , Malaysia
Funding
Dana Impak Perdana 2.0 · Universiti Kebangsaan Malaysia and Taif University, Taif, Saudi Arabia
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