Magnetic Nanomaterials in Microfluidic Sensors for Virus Detection: A Review
Source abstract
Abstract
Magnetic nanomaterials (MNMs) have gained great interest from different fields of study ranging from wastewater treatment to (bio)sensor development, taking advantage of both nanoscale size (allowing high surface-to-volume ratios) and the opportunity for magnetic manipulation. These materials can be surface-modified with antibodies, oligonucleotides, and aptamers to enable selective binding with target viruses or their biomarkers in biological samples. Using an external magnetic field, MNM-virus/biomarker complexes can be effectively isolated for further analysis. In some cases, the role of MNMs is not limited to simply serve as magnetic sorbents for extraction purposes as they have become an active part of some emerging detection processes (e.g., the use of magnetoresistive sensors). The combined application of MNMs with microfluidics for virus detection provides promising avenues for diagnostic tests that are of lower cost, require less time, and have higher specificity and sensitivity over conventional tests. This review focuses on the different approaches of virus detection using MNMs integrated in microfluidic chips. We will discuss recent research findings and provide insights and future perspectives for the development of low-cost and effective COVID-19 diagnostics tests.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Biosensors and Analytical Detection · Microfluidic and Bio-sensing Technologies · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838695, Iran
Influenza and Respiratory Viruses Department, Pasteur Institute of Iran, Tehran 1316943551, Iran
College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada
Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran
Autophagy Research Center, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran
Biotechnology Center, Silesian University of Technology, ul Bolesława Krzywoustego 8, 44-100 Gliwice, Poland
Linkocare Life Sciences AB, Teknikringen 10, Plan 3, 583 30 Linköping, Sweden
Science Impact, Winnipeg, Manitoba R2J 2L8, Canada
Institute of Fundamental Technological Research, Polish Academy of Sciences, Department of Theory of Continuous Media and Nanostructures, Pawińskiego 5B; 02-106 Warsaw, Poland
Department of Physics, Institute of Experimental Physics, Freie Universität, Arnimallee 14, 14195, Berlin, Germany
Faculty of Medicine, University of Technology, 40-555 Katowice, Poland
Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada
Research Institute of Oncology and Hematology, Cancer Care Manitoba, University of Manitoba, Winnipeg, Manitoba R3E 0V9, Canada
References (100+)
Show source-provided references
1. Cupić M. · Srp. Arh. Celok. Lek. · 2007 · 135 · 589
2. Diagnostic methods in virology, https://virology-online.com/general/Tests.htm#Overview.
3. 10.1097/01.inf.0000108187.63151.ea10.1097/01.inf.0000108187.63151.ea ↗
4. 10.1086/31401510.1086/314015 ↗
5. 10.1128/JCM.39.8.2779-2783.200110.1128/JCM.39.8.2779-2783.2001 ↗
6. Freshney R. · 2000
7. 10.1007/s40588-018-0105-y10.1007/s40588-018-0105-y ↗
8. Herold K. E. · 2009
9. 10.1042/EBC2015001310.1042/EBC20150013 ↗
10. 10.1016/j.bios.2020.11204110.1016/j.bios.2020.112041 ↗
11. 10.1016/j.aca.2016.11.06210.1016/j.aca.2016.11.062 ↗
12. 10.1016/B978-0-08-102985-5.00016-410.1016/B978-0-08-102985-5.00016-4 ↗
13. Afkhami A. · 2021
14. 10.1039/C4AY02144D10.1039/C4AY02144D ↗
15. 10.1007/s13738-015-0587-y10.1007/s13738-015-0587-y ↗
16. 10.1016/j.snb.2017.07.17810.1016/j.snb.2017.07.178 ↗
17. 10.1371/journal.pone.021979010.1371/journal.pone.0219790 ↗
18. 10.1002/ejic.20050049710.1002/ejic.200500497 ↗
19. 10.1103/PhysRevB.74.05443010.1103/PhysRevB.74.054430 ↗
20. 10.1088/0022-3727/32/22/10110.1088/0022-3727/32/22/101 ↗
21. 10.2147/IJN.S3032010.2147/IJN.S30320 ↗
22. 10.1016/j.trac.2019.02.02610.1016/j.trac.2019.02.026 ↗
23. 10.1016/j.ijbiomac.2020.02.17210.1016/j.ijbiomac.2020.02.172 ↗
24. 10.1016/j.apsusc.2020.14573810.1016/j.apsusc.2020.145738 ↗
25. 10.1016/j.jallcom.2019.15314210.1016/j.jallcom.2019.153142 ↗
26. 10.1016/j.msec.2019.11059710.1016/j.msec.2019.110597 ↗
27. 10.1016/j.mri.2020.02.00310.1016/j.mri.2020.02.003 ↗
28. 10.1039/C9NR07725A10.1039/C9NR07725A ↗
29. 10.1016/j.apcatb.2020.11868810.1016/j.apcatb.2020.118688 ↗
30. 10.1016/j.envpol.2020.11412710.1016/j.envpol.2020.114127 ↗
31. 10.3390/en1301017710.3390/en13010177 ↗
32. 10.1016/j.carbpol.2020.11596610.1016/j.carbpol.2020.115966 ↗
33. 10.1007/s13738-015-0675-z10.1007/s13738-015-0675-z ↗
34. 10.1007/s10800-019-01388-x10.1007/s10800-019-01388-x ↗
35. 10.1016/j.jelechem.2018.12.00410.1016/j.jelechem.2018.12.004 ↗
36. 10.1021/acs.analchem.9b0150610.1021/acs.analchem.9b01506 ↗
37. 10.1016/j.talanta.2018.01.02110.1016/j.talanta.2018.01.021 ↗
38. 10.1007/s13738-018-1350-y10.1007/s13738-018-1350-y ↗
39. 10.1016/j.snb.2015.01.00510.1016/j.snb.2015.01.005 ↗
40. 10.1007/s11696-020-01097-210.1007/s11696-020-01097-2 ↗
41. 10.1007/s10924-019-01632-710.1007/s10924-019-01632-7 ↗
42. 10.1007/s00216-020-02393-210.1007/s00216-020-02393-2 ↗
43. 10.1016/j.snb.2017.07.17810.1016/j.snb.2017.07.178 ↗
44. 10.1039/C4NJ01402B10.1039/C4NJ01402B ↗
45. 10.1016/j.talanta.2020.12197410.1016/j.talanta.2020.121974 ↗
46. 10.1016/j.bios.2018.08.06010.1016/j.bios.2018.08.060 ↗
47. 10.1016/j.ab.2005.07.03610.1016/j.ab.2005.07.036 ↗
48. 10.1166/jbn.2010.109310.1166/jbn.2010.1093 ↗
49. 10.1021/acsanm.0c0204810.1021/acsanm.0c02048 ↗
50. 10.1016/j.matt.2020.06.01510.1016/j.matt.2020.06.015 ↗
51. Pretorius, M.; Venter, M. Diagnosis of Viral Infections. In Viral Infections in Children; Green, R., Ed. Springer International Publishing, 2017; Vol. I, pp 151–182.10.1007/978-3-319-54033-7_6 ↗
52. Jeffery, K.; Aarons, E. Diagnostic approaches. In Principles and Practice of Clinical Virology; Zuckerman, A. J., Banatvala, J. E., Schoub, B. D., Griffiths, P. D., Mortimer, P., Eds. Wiley: New York, 2009; pp 1–27.
53. 10.3389/fmicb.2019.0195710.3389/fmicb.2019.01957 ↗
54. 10.1080/10408363.2021.188464010.1080/10408363.2021.1884640 ↗
55. 10.1590/1806-9282.66.7.88010.1590/1806-9282.66.7.880 ↗
56. 10.1021/acscentsci.0c0050110.1021/acscentsci.0c00501 ↗
57. 10.1111/j.1574-6941.2008.00629.x10.1111/j.1574-6941.2008.00629.x ↗
58. 10.1016/j.prrv.2007.07.00310.1016/j.prrv.2007.07.003 ↗
59. 10.1093/biohorizons/hzw01010.1093/biohorizons/hzw010 ↗
60. Bramhachari, P. V.; Mohana Sheela, G.; Prathyusha, A. M. V. N.; Madhavi, M.; Satish Kumar, K.; Reddy, N. N. R.; Berde, C. P. Advanced immunotechnological methods for Ddetection and diagnosis of viral infections: Current applications and future challenges. In Dynamics of Immune Activation in Viral Diseases, Bramhachari, P. V., Ed. Springer Singapore: Singapore, 2020; pp 261–275.10.1007/978-981-15-1045-8_17 ↗
61. 10.1016/j.phrp.2015.11.01110.1016/j.phrp.2015.11.011 ↗
62. 10.1042/EBC2015001210.1042/EBC20150012 ↗
63. Falcon, C. P. Facilitating AcceLerated Clinical Validation of Novel Diagnostics for COVID-19, www.condor-platform.org (accessed 2021-01-29).
64. 10.1021/la050553t10.1021/la050553t ↗
65. 10.1007/s00604-019-3410-010.1007/s00604-019-3410-0 ↗
66. 10.1016/j.jpba.2014.04.01710.1016/j.jpba.2014.04.017 ↗
67. 10.1021/ja203981w10.1021/ja203981w ↗
68. 10.1016/j.bios.2009.08.02010.1016/j.bios.2009.08.020 ↗
69. 10.1016/j.bios.2020.11259210.1016/j.bios.2020.112592 ↗
70. 10.1021/acsami.9b0392010.1021/acsami.9b03920 ↗
71. 10.3390/mi1102020310.3390/mi11020203 ↗
72. 10.1101/2020.02.22.96126810.1101/2020.02.22.961268 ↗
73. 10.1016/j.bios.2016.12.07110.1016/j.bios.2016.12.071 ↗
74. 10.1007/s11465-017-0460-z10.1007/s11465-017-0460-z ↗
75. 10.1039/C6LC00387G10.1039/C6LC00387G ↗
76. Samiei, E.; Hoorfar, M. Biosensing on Digital Microfluidics: From Sample Preparation to Detection. In Miniature Fluidic Devices for Rapid Biological Detection; Springer, 2018; pp 171–205.10.1007/978-3-319-64747-0_7 ↗
77. 10.1039/C7LC00025A10.1039/C7LC00025A ↗
78. 10.1039/B710928H10.1039/B710928H ↗
79. 10.1038/426515a10.1038/426515a ↗
80. 10.1007/s10404-007-0161-810.1007/s10404-007-0161-8 ↗
81. 10.1021/ac702269d10.1021/ac702269d ↗
82. 10.1039/c3lc50361e10.1039/c3lc50361e ↗
83. 10.1146/annurev-fluid-010313-14141810.1146/annurev-fluid-010313-141418 ↗
84. 10.1016/j.bios.2019.11185110.1016/j.bios.2019.111851 ↗
85. 10.1016/j.bios.2018.09.09210.1016/j.bios.2018.09.092 ↗
86. 10.1109/JMEMS.2003.82026710.1109/JMEMS.2003.820267 ↗
87. 10.1063/1.181997910.1063/1.1819979 ↗
88. Pei, S. N.; Valley, J. K.; Neale, S. L.; Jamshidi, A.; Hsu, H.Y.; Wu, M. C. Light-actuated digital microfluidics for large-scale, parallel manipulation of arbitrarily sized droplets. In 2010 IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS); IEEE, 2010; pp 252–255.10.1109/MEMSYS.2010.5442519 ↗
89. 10.1016/S0924-4247(03)00024-410.1016/S0924-4247(03)00024-4 ↗
90. 10.1021/acs.analchem.8b0000210.1021/acs.analchem.8b00002 ↗
91. 10.1016/j.snb.2020.12767510.1016/j.snb.2020.127675 ↗
92. 10.1039/C9LC01126A10.1039/C9LC01126A ↗
93. 10.1039/C5LC00660K10.1039/C5LC00660K ↗
94. 10.1128/JCM.00711-1810.1128/JCM.00711-18 ↗
95. 10.1016/j.trac.2014.06.01610.1016/j.trac.2014.06.016 ↗
96. 10.1109/JSEN.2006.87449310.1109/JSEN.2006.874493 ↗
97. Huang, H.; Garu, P.; Li, C.; Chang, W.; Chen, B.; Sung, S.; Lee, C.; Chen, J.; Hsieh, T.; Sheu, W. In Magnetoresistive Biosensors for Direct Detection of Magnetic Nanoparticle Conjugated Biomarkers on a Chip; Spin, World Scientific, 2019; p 1940002.10.1142/S2010324719400022 ↗
98. Ichkitidze, L.; Selishchev, S.; Telishev, D. Combined Magnetic Field Sensor with Nanosized Elements. In Advanced Materials; Springer, 2016; pp 591–601.10.1007/978-3-319-26324-3_42 ↗
99. Tumanski S. · 200110.1887/0750307021 ↗
100. 10.1016/S0304-8853(98)00376-X10.1016/S0304-8853(98)00376-X ↗