Antibacterial polymer nanofiber-coated and high elastin protein-expressing BMSCs incorporated polypropylene mesh for accelerating healing of female pelvic floor dysfunction
Source abstract
Abstract
Abstract To solve the bio-inertness of widely used polypropylene (PP) mesh for treating pelvic floor dysfunction (PFD), a novel strategy of incorporation with elastin gene-transfected bone marrow stem cells (BMSCs) and antibacteria drug-loaded polylactic acid (PLA) nanofibrous mat covering layer was proposed to overcome the limitation of the pristine PP mesh. Then, a series of physicochemical and in vitro experiments were applied to investigate the improvement of the as-prepared material. The elastin protein expression was proved to be upregulated without obvious cytotoxicity influence after the gene transfection and also improved the cell migration rate. In addition, the antibacteria drug-loaded PLA nanofibrous mat on the PP mesh could efficiently inhibit bacteria and showed no significant impact on cell adhesion and proliferation. Thus, we believe that the incorporation of the elastin gene-transfected BMSCs and nanofiber-coated PP mesh would be a potential candidate in the application of female PFD.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Pelvic floor disorders treatments · Hernia repair and management · Wound Healing and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Obstetrics and Gynaecology, Tongji Hospital of Tongji University, Tongji University School of Medicine , Shanghai , 200065 , China
Department of Orthopaedics, Minhang Hospital, Fudan University , Shanghai , 201199 , China
School of Textile and Clothing, Nantong University , Nantong , 226019 , China
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai , 201620 , China
Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles , Donghua University, 201620 , China
References (46)
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