Yb3+-containing chitosan hydrogels induce B-16 melanoma cell anoikis via a Fak-dependent pathway
Source abstract
Abstract
Abstract Melanoma is the most lethal dermal tumor, and a high recurrence rate and skin defects are two main serious problems. An antimelanoma material,which effectively inhibits tumor recurrence and possesses excellent biocompatibility, is urgently needed to treat melanoma. In this study, we developed a novel antitumor Yb3+ [Yb(NO3)3]containing chitosan hydrogel (Yb-CS hydrogel) by dissolving Yb(NO3)3 and chitosan in acetic acid solution and forming composite hydrogels by a freeze-drying process after adding NaOH to the mixed solution. In vitro studies demonstrated that the Yb3+ produces effect of inducing cell death in Yb-CS hydrogel. Moreover, we found that the Yb-CS hydrogel inhibited a focal adhesion kinase (FAK)-dependent signaling pathway and induced B-16 cell anoikis. However, the Yb-CS hydrogel was less effective on L929 normal mouse dermal cells. In vivo studies showed that the Yb-CS hydrogel inhibited the recurrence of melanoma in a mouse bare xenograft tumor model. We concluded that the Yb-CS hydrogel could potentially be used in the antimelanoma field, especially in the inhibition of melanoma recurrence.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Cell Adhesion Molecules Research · Mast cells and histamine · Wound Healing and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institution of microsurgery for Limbs, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai200233, China
The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai200234, China
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu610064, China
References (60)
Show source-provided references
1. Serum microRNAs as biomarkers for recurrence in melanoma10.1186/1479-5876-10-155 ↗
2. SC79-loaded ZSM-5/chitosan porous scaffolds with enhanced stem cell osteogenic differentiation and bone regeneration
3. Managing malignant melanoma Plast
4. Upregulated WDR5 promotes proliferation
5. Metastatic uveal melanoma therapy: current options
6. Contemporary and potential future molecular diagnosis of melanoma
7. c-FLIPp43 induces activation of the nuclear factorkappaB signaling pathway in a dose-dependent manner in the A375 melanoma cell line
8. Proteomic detection of changes in protein synthesis induced by lanthanum in BGC-823 human gastric cancer cells
9. Anoikis molecular pathways and its role in cancer progression
10. Contemporary and potential future molecular diagnosis of melanoma
11. Anoikis molecular pathways and its role in cancer progression
12. Heterogeneous nuclear ribonucleoprotein K is associated with poor prognosis and regulates proliferation and apoptosis in bladder cancer10.1111/jcmm.12999 ↗
13. SC79-loaded ZSM-5/chitosan porous scaffolds with enhanced stem cell osteogenic differentiation and bone regeneration
14. Lanthanum chloride enhances cisplatin-induced apoptosis in ovarian cancer cells
15. GdCl3 induced Hep G2 cell death through mitochondrial and external death pathways without significant elevation of ROS generation
16. FAK overexpression and p53 mutations are highly correlated in human breast cancer
17. Bioinspired fabrication of carbonated hydroxyapatite/chitosan nanohybrid scaffolds loaded with TWS119 for bone regeneration10.1016/j.cej.2018.02.010 ↗
18. Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis
19. Systemic treatment of distant metastatic malignant melanoma
20. Proteomic detection of changes in protein synthesis induced by lanthanum in BGC-823 human gastric cancer cells
21. Inhibition of Transient Receptor Potential Melastain 7 Enhances Apoptosis Induced by TRAIL in PC-3 cells
22. Production and quality control of radioactive yttrium microspheres for medical applications10.1016/j.apradiso.2013.12.009 ↗
23. Gadolinium chloride elicits apoptosis in human osteosarcoma U-2 OS cells through extrinsic signaling
24. Recent Developments in Melanoma Therapy
25. GdCl3 induced Hep G2 cell death through mitochondrial and external death pathways without significant elevation of ROS generation
26. Toxicity study of cerium oxide nanoparticles in human neuroblastoma cells
27. Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance
28. The effects of lanthanumchloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs
29. Serum microRNAs as biomarkers for recurrence in melanoma10.1186/1479-5876-10-155 ↗
30. Heterogeneous nuclear ribonucleoprotein K is associated with poor prognosis and regulates proliferation and apoptosis in bladder cancer10.1111/jcmm.12999 ↗
31. c-FLIPp43 induces activation of the nuclear factorkappaB signaling pathway in a dose-dependent manner in the A375 melanoma cell line
32. Synthesis and optimization of electric conductivity and thermal diffusivity of zincaluminum hydroxide (Zn–Al–NO3–LDH) prepared at different pH values
33. YCl3 Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats
34. Doxorubicin-loaded NaYF4:Yb/Tm-TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers10.1016/j.biomaterials.2015.04.006 ↗
35. Upregulated WDR5 promotes proliferation
36. Production and quality control of radioactive yttrium microspheres for medical applications10.1016/j.apradiso.2013.12.009 ↗
37. Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance
38. A novel Cd2+ -imprinted chitosan-based composite membrane for Cd2+ removal from aqueous solution10.1016/j.matlet.2017.04.006 ↗
39. Endosomes: emerging platforms for integrinmediated FAK signalling
40. A novel Cd2+ -imprinted chitosan-based composite membrane for Cd2+ removal from aqueous solution10.1016/j.matlet.2017.04.006 ↗
41. Metastatic uveal melanoma therapy: current options
42. YCl3 Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats
43. Toxicity study of cerium oxide nanoparticles in human neuroblastoma cells
44. Recent Developments in Melanoma Therapy
45. Management of melanoma
46. Bioinspired fabrication of carbonated hydroxyapatite/chitosan nanohybrid scaffolds loaded with TWS119 for bone regeneration10.1016/j.cej.2018.02.010 ↗
47. The effects of lanthanumchloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs
48. Management of melanoma
49. Doxorubicin-loaded NaYF4:Yb/Tm-TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers10.1016/j.biomaterials.2015.04.006 ↗
50. Endosomes: emerging platforms for integrinmediated FAK signalling
51. Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis
52. Gadolinium chloride elicits apoptosis in human osteosarcoma U-2 OS cells through extrinsic signaling
53. Lanthanum chloride enhances cisplatin-induced apoptosis in ovarian cancer cells
54. Managing malignant melanoma Plast
55. Lanthanum citrate induces anoikis of Hela cells
56. Systemic treatment of distant metastatic malignant melanoma
57. Synthesis and optimization of electric conductivity and thermal diffusivity of zincaluminum hydroxide (Zn–Al–NO3–LDH) prepared at different pH values
58. Lanthanum citrate induces anoikis of Hela cells
59. FAK overexpression and p53 mutations are highly correlated in human breast cancer
60. Inhibition of Transient Receptor Potential Melastain 7 Enhances Apoptosis Induced by TRAIL in PC-3 cells