Conversion of sub-µm calcium carbonate (calcite) particles to hollow hydroxyapatite agglomerates in K2HPO4 solutions
Source abstract
Abstract
Abstract Sub-µm CaCO3 (calcite; CC) particles were converted to calcium monohydrogenphosphate dihydrate (DCPD) and hydroxyapatite (HAp) via soaking treatments in K2HPO4 solutions with varied pH (3–12) and concentrations (0.1–1.5 M) at 37°C for up to 10 days. DCPD was derived from the solutions with pH ≤ 6; while hollow HAp was yielded when pH ≥ 7 in assemblies of petal-like crystallites. Results of magic angle spinning (MAS) and cross-polarization magic angle spinning (CP-MAS) NMR studies have shown that the HAp lattice has only PO4 2− but no HPO4 2− at B (phosphate) sites. Trace amounts of CO3 2− have occupied both A (OH) and B (PO4) sites, and H2O is adsorbed on surface crystallites. The primary crystallite size of HAp derived from Scherrer equation increases quickly in a 12 h period and becomes gradually stable afterward. Samples of particles soaked within 3 h in a temperature range of 20–80°C were analyzed by X-ray diffraction. It is shown that the rate constant of 1 M solution is about an order of magnitude greater than that of 0.1 M solution and the apparent activation energy is 33 kJ/mol. In this work, the conversion of CC to HAp can be quantitatively controlled to solve the problem of slow degradation of HAp.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Calcium Carbonate Crystallization and Inhibition · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Materials Science and Engineering, Henan University of Science and Technology , Luoyang , Henan Province, 471023 , China
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University , Tsushima, Okayama , 700-8530 , Japan
Faculty of Engineering, Okayama University , Tsushima, Okayama , 700-8530 , Japan
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