An updated overview of nanoparticle-induced cardiovascular toxicity
Source abstract
Abstract
Abstract The cardiovascular system is pivotal in the systemic distribution and toxicity of nanoparticles (NPs) upon their entry into circulation. Therefore, it is crucial to extensively investigate the adverse cardiovascular effects of NPs. This review presents the advancements in understanding the cardiovascular distribution of NPs and their potential adverse effects, particularly in humans. We first discussed the uptake and distribution of NPs in cardiovascular tissues and cells, which result in adverse outcomes such as hemolysis, blood coagulation dysfunction, vascular endothelial damage, and cardiac pathological damage and function impairment. Additionally, we discuss the current understanding of the mechanisms underlying NP-induced cardiovascular toxicity, including oxidative stress, inflammation, mitochondrial damage, and autophagy. Moreover, we systematically reviewed the factors influencing NPs circulation, retention, clearance, and toxicity within the cardiovascular system, which include the primary physicochemical properties of NPs, modifications of NPs with biological molecules, physiological and pathological conditions of the body, and their interaction with other environmental chemicals. Finally, we proposed the challenges associated with NP cardiovascular toxicity, with the aim of providing insights into the interactions between NPs and cardiovascular components and offering valuable perspectives for the development of safer NP-based therapies and biomedical applications.
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Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Graphene and Nanomaterials Applications · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Cardiology, Zibo Central Hospital , Zibo , Shandong, 255020 , China
Department of Coronary Care Unit, Zibo Central Hospital , Zibo , Shandong, 255020 , China
Jinan Customs Technical Center , Jinan , Shandong, 250012 , China
School of Environment, Hangzhou Institute for Advanced Study, UCAS , Hangzhou , Zhejiang, 310024 , China
Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University , Jinan , Shandong, 250100 , China
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