Decellularized extracellular matrix as a promising biomaterial for musculoskeletal tissue regeneration
Source abstract
Abstract
Abstract The emergence of tissue engineering provides an alternative therapeutic strategy for various regeneration. It is the crucial step for choosing an ideal scaffold to support the cellular behaviors of various functional cells. Various biomaterials have been found or synthesized and applied to tissue repair. Among these biomaterials, as a natural-derived material, decellularized extracellular matrix (dECM) derived from cells, tissues, and organs is attracting more and more interest due to its good biocompatibility, biodegradability, and the ability to mimic a microenvironment similar to extracellular matrix. More and more researchers utilized dECM derived from cells, tissues, and organs to fabricate tissue-engineered scaffolds to repair musculoskeletal tissues, since the bioactive molecules of dECM, such as fibrous proteins, proteoglycans, and adhesive glycoproteins, could provide various bioactive cues for tissue regeneration and remodeling. The physiochemical properties of dECM can be enhanced by changing decellularization and modification techniques. In addition, dECM can act as carriers of drugs, factors, or exosomes, delivering agents to injured tissues and promoting tissue repair and regeneration. Therefore, we conduct this review to discuss the current status and challenges of dECM in repairing the musculoskeletal system. Furthermore, the fabrication and modification of dECM were also discussed in our study.
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Research context
OpenAlex topics: Tissue Engineering and Regenerative Medicine · Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University , Chengdu , China
West China School of Medicine, Sichuan University , Chengdu , Sichuan , China
Department of Molecular Brain Physiology and Behavior, LIMES Institute, University of Bonn , Bonn , Germany
West China Hospital of Stomatology, Sichuan University , Chengdu 610041 , Sichuan , China
Animal Experiment Center, West China Hospital, Sichuan University , Chengdu , Sichuan , China
National Engineering Research Center for Biomaterials, Sichuan University , Chengdu 610064 , China
College of Biomedical Engineering, Sichuan University , Chengdu 610064 , China
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