Micelle-based nanoparticles with stimuli-responsive properties for drug delivery
Source abstract
Abstract
Abstract Cancer treatment often causes adverse effects and toxicity, as chemotherapy drugs affect both cancerous and healthy cells. Scientists seek to target tumor cells specifically and minimize harm to normal cells. Smart nanoparticles (NPs) are a modern technique that can release drugs when triggered by internal or external stimuli, such as temperature, pH, ultrasound, etc . This review covers stimuli-responsive micelle-based nanoparticles (SRM-NPs), a promising drug delivery platform that can enhance drug efficacy and reduce toxicity. It discusses the recent developments and applications of SRM-NPs, their responsiveness to different stimuli, and their potential to overcome drug resistance and adaptive responses. It also addresses the challenges and issues related to their stability, reproducibility, biocompatibility, safety, and optimization. The study concludes that SRM-NPs have great potential for drug delivery, but more research and development are needed to improve their clinical utility.
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Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Advanced Drug Delivery Systems
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi University , Tehran , Iran
Department of Medical Genetics, School of Medicine, Babol University of Medical Sciences , Babol , Iran
Plasma Medicine Group, Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences , Jalale-Al-Ahmad Ave, 1411713137 , Tehran , Iran
Department of Physics, Kharazmi University , 49 Dr. Mofatteh Ave , Tehran , 15614 , Iran
Research and Development, Science and Emerging Technologies , Aerogen Limited, Galway Business Park , Galway , H91 HE94 , Ireland
School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland , Dublin , D02 YN77 , Ireland
School of Pharmacy and Pharmaceutical Sciences, Trinity College , Dublin , D02 PN40 , Ireland
ZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Str 2 , 17489 , Greifswald , Germany
Clinic and Policlinic for Dermatology and Venerology, Rostock University Medical Center , Strempelstr. 13, 18057 , Rostock , Germany
References (100+)
Show source-provided references
1. Tracey SR, Smyth P, Barelle CJ, Scott CJ. Development of next generation nanomedicine-based approaches for the treatment of cancer: We’ve barely scratched the surface. Biochem Soc Trans. 2021;49(5):2253–69.10.1042/BST20210343 ↗
2. Cheng YL, He CL, Xiao CS, Ding JX, Ren KX, Yu SJ, et al. Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry. Polym Chem. 2013;4(13):3851–8.10.1039/c3py00364g ↗
3. Kooti W, Ghaleh HEG, Farzanehpour M, Dorostkar R, Kondori BJ, Bolandian M. Oncolytic viruses and cancer, Do you know the main mechanism? Front Oncol. 2021;11:761015.10.3389/fonc.2021.761015 ↗
4. Papiez MA, Krzysciak W. Biological therapies in the treatment of cancer-update and new directions. Int J Mol Sci. 2021;22(21):11694.10.3390/ijms222111694 ↗
5. Cabral H, Kataoka K. Progress of drug-loaded polymeric micelles into clinical studies. J Control Rel. 2014;190:465–76.10.1016/j.jconrel.2014.06.042 ↗
6. Florczak A, Deptuch T, Kucharczyk K, Dams-Kozlowska H. Systemic and local silk-based drug delivery systems for cancer therapy. Cancers (Basel). 2021;13(21):5389.10.3390/cancers13215389 ↗
7. Carvalheiro M, Ferreira-Silva M, Holovanchuk D, Marinho HS, Moreira JN, Soares H, et al. Antagonist G-targeted liposomes for improved delivery of anticancer drugs in small cell lung carcinoma. Int J Pharm. 2022;612:121380.10.1016/j.ijpharm.2021.121380 ↗
8. Yang G, Wang J, Li D, Zhou S. Polyanhydride micelles with diverse morphologies for shape-regulated cellular internalization and blood circulation. Regen Biomater. 2017;4(3):149–57.10.1093/rb/rbw047 ↗
9. Niculescu AG, Grumezescu AM. Novel tumor-targeting nanoparticles for cancer treatment–A review. Int J Mol Sci. 2022;23(9):5253.10.3390/ijms23095253 ↗
10. Xing X, Guo Z, Su Y, Yang Z, Qian J, Tu C, et al. A smart core-crosslinked supramolecular drug delivery system (SDDS) enabled by pendant cyclodextrins encapsulation of drug dimers via host-guest interaction. Biosens (Basel). 2021;11(9):306.10.3390/bios11090306 ↗
11. Berillo D, Yeskendir A, Zharkinbekov Z, Raziyeva K, Saparov A. Peptide-based drug delivery systems. Medicina (Kaunas). 2021;57(11):1209.10.3390/medicina57111209 ↗
12. Loverde SM, Klein ML, Discher DE. Nanoparticle shape improves delivery: rational coarse grain molecular dynamics (rCG-MD) of taxol in worm-like PEG-PCL micelles. Adv Mater. 2012;24(28):3823–30.10.1002/adma.201103192 ↗
13. Kim TH, Mount CW, Dulken BW, Ramos J, Fu CJ, Khant HA, et al. Filamentous, mixed micelles of triblock copolymers enhance tumor localization of indocyanine green in a murine xenograft model. Mol Pharm. 2012;9(1):135–43.10.1021/mp200381c ↗
14. Cano-Cortes MV, Altea-Manzano P, Laz-Ruiz JA, Unciti-Broceta JD, Lopez-Delgado FJ, Espejo-Roman JM, et al. An effective polymeric nanocarrier that allows for active targeting and selective drug delivery in cell coculture systems. Nanoscale. 2021;13(6):3500–11.10.1039/D0NR07145E ↗
15. Abbas Y, Azzazy HM, Tammam S, Lamprecht A, Ali ME, Schmidt A, et al. Development of an inhalable, stimuli-responsive particulate system for delivery to deep lung tissue. Colloids Surf B Biointerfaces. 2016;146:19–30.10.1016/j.colsurfb.2016.05.031 ↗
16. Wong KE, Ngai SC, Chan KG, Lee LH, Goh BH, Chuah LH. Curcumin nanoformulations for colorectal cancer: A review. Front Pharmacol. 2019;10:152.10.3389/fphar.2019.00152 ↗
17. Su L, Li RC, Khan S, Clanton R, Zhang FW, Lin YN, et al. Chemical design of both a glutathione-sensitive dimeric drug guest and a glucose-derived nanocarrier host to achieve enhanced osteosarcoma lung metastatic anticancer selectivity. J Am Chem Soc. 2018;140(4):1438–46.10.1021/jacs.7b11462 ↗
18. Doroudian M, Azhdari MH, Goodarzi N, O’Sullivan D, Donnelly SC. Smart nanotherapeutics and lung cancer. Pharmaceutics. 2021;13(11):1972.10.3390/pharmaceutics13111972 ↗
19. Hosseinkazemi H, Samani S, O’Neill A, Soezi M, Moghoofei M, Azhdari MH, et al. Applications of iron oxide nanoparticles against breast cancer. J Nanomaterials. 2022;2022:6493458.10.1155/2022/6493458 ↗
20. Monajati M, Tavakoli S, Abolmaali SS, Yousefi G, Tamaddon A. Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma. Bioimpacts. 2018;8(4):241–52.10.15171/bi.2018.27 ↗
21. Adepu S, Ramakrishna S. Controlled drug delivery systems: Current status and future directions. Molecules. 2021;26(19):5905.10.3390/molecules26195905 ↗
22. Truong NP, Whittaker MR, Mak CW, Davis TP. The importance of nanoparticle shape in cancer drug delivery. Expert Opin Drug Deliv. 2015;12(1):129–42.10.1517/17425247.2014.950564 ↗
23. Veselov VV, Nosyrev AE, Jicsinszky L, Alyautdin RN, Cravotto G. Targeted delivery methods for anticancer drugs. Cancers (Basel). 2022;14(3):622.10.3390/cancers14030622 ↗
24. Augustine R, Kalva N, Kim HA, Zhang Y, Kim I. pH-responsive polypeptide-based smart nano-carriers for theranostic applications. Molecules. 2019;24(16):2961.10.3390/molecules24162961 ↗
25. Sun R, Dai J, Ling M, Yu L, Yu Z, Tang L. Delivery of triptolide: A combination of traditional Chinese medicine and nanomedicine. J Nanobiotechnology. 2022;20(1):194.10.1186/s12951-022-01389-7 ↗
26. Chandrakala V, Aruna V, Angajala G. Review on metal nanoparticles as nanocarriers: Current challenges and perspectives in drug delivery systems. Emergent Mater. 2022;5(6):1593–615.10.1007/s42247-021-00335-x ↗
27. Kuang Y, Zhai J, Xiao Q, Zhao S, Li C. Polysaccharide/mesoporous silica nanoparticle-based drug delivery systems: A review. Int J Biol Macromolecules. 2021;193:457–73.10.1016/j.ijbiomac.2021.10.142 ↗
28. Kenchegowda M, Rahamathulla M, Hani U, Begum MY, Guruswamy S, Osmani RAM, et al. Smart nanocarriers as an emerging platform for cancer therapy: A review. Molecules. 2021;27(1):146.10.3390/molecules27010146 ↗
29. Liu Y, Tan J, Thomas A, Ou-Yang D, Muzykantov VR. The shape of things to come: Importance of design in nanotechnology for drug delivery. Ther Deliv. 2012;3(2):181–94.10.4155/tde.11.156 ↗
30. Yousefi Dehbidi M, Goodarzi N, Azhdari MH, Doroudian M. Mesenchymal stem cells and their derived exosomes to combat Covid–19. Rev Med Virol. 2022;32(2):e2281.10.1002/rmv.2281 ↗
31. Azhdari MH, Goodarzi N, Doroudian M, MacLoughlin R. Molecular insight into the therapeutic effects of stem cell-derived exosomes in respiratory diseases and the potential for pulmonary delivery. Int J Mol Sci. 2022;23(11):6273.10.3390/ijms23116273 ↗
32. Bose A, Roy Burman D, Sikdar B, Patra P. Nanomicelles: Types, properties and applications in drug delivery. IET Nanobiotechnol. 2021;15(1):19–27.10.1049/nbt2.12018 ↗
33. Ganta S, Devalapally H, Shahiwala A, Amiji M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J Control Rel. 2008;126(3):187–204.10.1016/j.jconrel.2007.12.017 ↗
34. Kataoka K, Harada A, Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev. 2012;64:37–48.10.1016/j.addr.2012.09.013 ↗
35. Liu P, Chen G, Zhang J. A review of liposomes as a drug delivery system: current status of approved products, regulatory environments, and future perspectives. Molecules. 2022;27(4):1372.10.3390/molecules27041372 ↗
36. Nsairat H, Khater D, Sayed U, Odeh F, Al Bawab A, Alshaer W. Liposomes: Structure, composition, types, and clinical applications. Heliyon. 2022;8(5):e09394.10.1016/j.heliyon.2022.e09394 ↗
37. Huang D, Wu D. Biodegradable dendrimers for drug delivery. Mater Sci Eng: C. 2018;90:713–27.10.1016/j.msec.2018.03.002 ↗
38. Yusuf A, Almotairy ARZ, Henidi H, Alshehri OY, Aldughaim MS. Nanoparticles as drug delivery systems: A review of the implication of nanoparticles’ physicochemical properties on responses in biological systems. Polymers. 2023;15(7):1596.10.3390/polym15071596 ↗
39. Aziz T, Ullah A, Ali A, Shabeer M, Shah MN, Haq F, et al. Manufactures of bio‐degradable and bio‐based polymers for bio‐materials in the pharmaceutical field. J Appl Polym Sci. 2022;139(29):e52624.10.1002/app.52624 ↗
40. Jayaramudu T, Varaprasad K, Reddy KK, Sisubalan N, Patil AJ, Sadiku ER, et al. Polymers used in green synthesis of nanoparticles and their importance in pharmaceutical and biomedical applications. In: Kokkarachedu V, editor. Woodhead Publishing Series in Biomaterials, Polymeric Biomaterials for Healthcare Applications. Woodhead Publishing; 2022. p. 125–63.10.1016/B978-0-323-85233-3.00004-5 ↗
41. Raj S, Khurana S, Choudhari R, Kesari KK, Kamal MA, Garg N, et al. editors. Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy. Seminars in cancer biology. Elsevier; 2021.10.1016/j.semcancer.2019.11.002 ↗
42. Bianco A, Kostarelos K, Prato M. Making carbon nanotubes biocompatible and biodegradable. Chem Commun. 2011;47(37):10182–8.10.1039/c1cc13011k ↗
43. Mehra NK, Jain N. Development, characterization and cancer targeting potential of surface engineered carbon nanotubes. J Drug Target. 2013;21(8):745–58.10.3109/1061186X.2013.813028 ↗
44. Gidwani B, Sahu V, Shukla SS, Pandey R, Joshi V, Jain VK, et al. Quantum dots: Prospectives, toxicity, advances and applications. J Drug Deliv Sci Technol. 2021;61:102308.10.1016/j.jddst.2020.102308 ↗
45. Kaur H, Garg R, Singh S, Jana A, Bathula C, Kim H-S, et al. Progress and challenges of graphene and its congeners for biomedical applications: Drug delivery, gene delivery, biosensing, bioimaging, and tissue engineering. J Mol Liq. 2022;368:120703.10.1016/j.molliq.2022.120703 ↗
46. Kurian M, Paul A. Recent trends in the use of green sources for carbon dot synthesis–A short review. Carbon Trends. 2021;3:100032.10.1016/j.cartre.2021.100032 ↗
47. Doppalapudi S, Jain A, Khan W, Domb AJ. Biodegradable polymers—an overview. Polym Adv Technol. 2014;25(5):427–35.10.1002/pat.3305 ↗
48. Joshi M, Nagarsenkar M, Prabhakar B. Albumin nanocarriers for pulmonary drug delivery: An attractive approach. J Drug Deliv Sci Technol. 2020;56:101529.10.1016/j.jddst.2020.101529 ↗
49. Spada A, Emami J, Tuszynski JA, Lavasanifar A. The uniqueness of albumin as a carrier in nanodrug delivery. Mol Pharm. 2021;18(5):1862–94.10.1021/acs.molpharmaceut.1c00046 ↗
50. Dattani S, Li X, Lampa C, Lechuga-Ballesteros D, Barriscale A, Damadzadeh B, et al. A comparative study on micelles, liposomes and solid lipid nanoparticles for paclitaxel delivery. Int J Pharm. 2023;631:122464.10.1016/j.ijpharm.2022.122464 ↗
51. Hejabi F, Abbaszadeh MS, Taji S, O’Neill A, Farjadian F, Doroudian M. Nanocarriers: A novel strategy for the delivery of CRISPR/Cas systems. Front Chem. 2022;10:957572.10.3389/fchem.2022.957572 ↗
52. Segal M, Ozery L, Slor G, Wagle SS, Ehm T, Beck R, et al. Architectural change of the shell-forming block from linear to V-shaped accelerates micellar disassembly, but slows the complete enzymatic degradation of the amphiphiles. Biomacromolecules. 2020;21(10):4076–86.10.1021/acs.biomac.0c00882 ↗
53. Fatfat Z, Fatfat M, Gali-Muhtasib H. Micelles as potential drug delivery systems for colorectal cancer treatment. World J Gastroenterol. 2022;28(25):2867–80.10.3748/wjg.v28.i25.2867 ↗
54. Wang Z, Li Y, Zhang T, Li H, Yang Z, Wang C. Effect of micelle-incorporated cisplatin with sizes ranging from 8 to 40 nm for the therapy of Lewis lung carcinoma. Front Pharmacol. 2021;12:632877.10.3389/fphar.2021.632877 ↗
55. Parra A, Jarak I, Santos A, Veiga F, Figueiras A. Polymeric micelles: A promising pathway for dermal drug delivery. Materials (Basel). 2021;14(23):7278.10.3390/ma14237278 ↗
56. Majumder N, G Das N, Das SK. Polymeric micelles for anticancer drug delivery. Ther Deliv. 2020;11(10):613–35.10.4155/tde-2020-0008 ↗
57. Xie L, Liu R, Chen X, He M, Zhang Y, Chen S. Micelles based on lysine, histidine, or arginine: Designing structures for enhanced drug delivery. Front Bioeng Biotechnol. 2021;9:744657.10.3389/fbioe.2021.744657 ↗
58. Lo YL, Huang XS, Chen HY, Huang YC, Liao ZX, Wang LF. ROP and ATRP fabricated redox sensitive micelles based on PCL-SS-PMAA diblock copolymers to co-deliver PTX and CDDP for lung cancer therapy. Colloids Surf B Biointerfaces. 2021;198:111443.10.1016/j.colsurfb.2020.111443 ↗
59. Zhang W, Taheri-Ledari R, Ganjali F, Afruzi FH, Hajizadeh Z, Saeidirad M, et al. Nanoscale bioconjugates: A review of the structural attributes of drug-loaded nanocarrier conjugates for selective cancer therapy. Heliyon. 2022;8(6):e09577.10.1016/j.heliyon.2022.e09577 ↗
60. Zhang P, Zhu Y, Xiao C, Chen X. Activatable dual-functional molecular agents for imaging-guided cancer therapy. Adv Drug Deliv Rev. 2023;195:114725.10.1016/j.addr.2023.114725 ↗
61. Guragain S, Bastakoti BP, Malgras V, Nakashima K, Yamauchi Y. Multi-stimuli-responsive polymeric materials. Chemistry (Easton). 2015;21(38):13164–74.10.1002/chem.201501101 ↗
62. Irshad S, Siddiqui B, ur Rehman A, Farooq RK, Ahmed N. Recent trends and development in targeted delivery of therapeutics through enzyme responsive intelligent nanoplatform. Int J Polymeric Mater Polymeric Biomater. 2022;71(6):403–13.10.1080/00914037.2020.1848829 ↗
63. Gong J, Chen M, Zheng Y, Wang S, Wang Y. Polymeric micelles drug delivery system in oncology. J Control Rel. 2012;159(3):312–23.10.1016/j.jconrel.2011.12.012 ↗
64. Owen SC, Chan DPY, Shoichet MS. Polymeric micelle stability. Nano Today. 2012;7(1):53–65.10.1016/j.nantod.2012.01.002 ↗
65. Kuntsche J, Horst JC, Bunjes H. Cryogenic transmission electron microscopy (cryo-TEM) for studying the morphology of colloidal drug delivery systems. Int J Pharm. 2011;417(1–2):120–37.10.1016/j.ijpharm.2011.02.001 ↗
66. Ghezzi M, Pescina S, Padula C, Santi P, Del Favero E, Cantù L, et al. Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions. J Control Rel. 2021;332:312–36.10.1016/j.jconrel.2021.02.031 ↗
67. Zhu Y, Meng T, Tan Y, Yang X, Liu Y, Liu X, et al. Negative surface shielded polymeric micelles with colloidal stability for intracellular endosomal/lysosomal escape. Mol Pharm. 2018;15(11):5374–86.10.1021/acs.molpharmaceut.8b00842 ↗
68. Honary S, Zahir F. Effect of zeta potential on the properties of nano-drug delivery systems - A review (Part 2). Trop J Pharm Res. 2013;12(2):265–73.10.4314/tjpr.v12i2.20 ↗
69. Zhao JC, Stenzel MH. Entry of nanoparticles into cells: the importance of nanoparticle properties. Polym Chem. 2018;9(3):259–72.10.1039/C7PY01603D ↗
70. Li J, Li Z, Zhou T, Zhang J, Xia H, Li H, et al. Positively charged micelles based on a triblock copolymer demonstrate enhanced corneal penetration. Int J Nanomed. 2015;10:6027–37.10.2147/IJN.S90347 ↗
71. Junnuthula V, Kolimi P, Nyavanandi D, Sampathi S, Vora LK, Dyawanapelly S. Polymeric micelles for breast cancer therapy: Recent updates, clinical translation and regulatory considerations. Pharmaceutics. 2022;14(9):1860.10.3390/pharmaceutics14091860 ↗
72. Vllasaliu D, Fowler R, Stolnik S. PEGylated nanomedicines: Recent progress and remaining concerns. Expert Opin Drug Deliv. 2014;11(1):139–54.10.1517/17425247.2014.866651 ↗
73. Logie J, Owen SC, McLaughlin CK, Shoichet MS. PEG-graft density controls polymeric nanoparticle micelle stability. Chem Mater. 2014;26(9):2847–55.10.1021/cm500448x ↗
74. Auria-Soro C, Nesma T, Juanes-Velasco P, Landeira-Vinuela A, Fidalgo-Gomez H, Acebes-Fernandez V, et al. Interactions of nanoparticles and biosystems: Microenvironment of nanoparticles and biomolecules in nanomedicine. Nanomaterials (Basel). 2019;9(10):1365.10.3390/nano9101365 ↗
75. Yokoyama M. Polymeric micelles as a new drug carrier system and their required considerations for clinical trials. Expert Opin Drug Deliv. 2010;7(2):145–58.10.1517/17425240903436479 ↗
76. Muthu MS, Rajesh CV, Mishra A, Singh S. Stimulus-responsive targeted nanomicelles for effective cancer therapy. Nanomedicine (Lond). 2009;4(6):657–67.10.2217/nnm.09.44 ↗
77. Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol. 2018;16(1):71.10.1186/s12951-018-0392-8 ↗
78. Rodriguez F, Caruana P, De la Fuente N, Espanol P, Gamez M, Balart J, et al. Nano-based approved pharmaceuticals for cancer treatment: Present and future challenges. Biomolecules. 2022;12:784.10.3390/biom12060784 ↗
79. Wang X, Li C, Wang Y, Chen H, Zhang X, Luo C, et al. Smart drug delivery systems for precise cancer therapy. Acta Pharm Sin B. 2022;12(11):4098–121.10.1016/j.apsb.2022.08.013 ↗
80. Almeida M, Magalhães M, Veiga F, Figueiras A. Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer. J Polym Res. 2018;25(1):1–14.10.1007/s10965-017-1426-x ↗
81. Ahmad Z, Shah A, Siddiq M, Kraatz HB. Polymeric micelles as drug delivery vehicles. Rsc Adv. 2014;4(33):17028–38.10.1039/C3RA47370H ↗
82. Karimi MA, Mozaheb MA, Hatefi-Mehrjardi A, Tavallali H, Attaran AM, Shamsi R. A new simple method for determining the critical micelle concentration of surfactants using surface plasmon resonance of silver nanoparticles. J Anal Sci Technol. 2015;6(1):1–8.10.1186/s40543-015-0077-y ↗
83. Scholz N, Behnke T, Resch-Genger U. Determination of the critical micelle concentration of neutral and ionic surfactants with fluorometry, conductometry, and surface tension – A method comparison. J Fluoresc. 2018;28(1):465–76.10.1007/s10895-018-2209-4 ↗
84. Topel O, Cakir BA, Budama L, Hoda N. Determination of critical micelle concentration of polybutadiene-block-poly(ethyleneoxide) diblock copolymer by fluorescence spectroscopy and dynamic light scattering. J Mol Liq. 2013;177:40–3.10.1016/j.molliq.2012.10.013 ↗
85. Gadelha G, Nawaz MS, Hankins NP, Khan SJ, Wang R, Tang CYY. Assessment of micellar solutions as draw solutions for forward osmosis. Desalination. 2014;354:97–106.10.1016/j.desal.2014.09.009 ↗
86. Lee SY, Tyler JY, Kim S, Park K, Cheng JX. FRET imaging reveals different cellular entry routes of self-assembled and disulfide bonded polymeric micelles. Mol Pharm. 2013;10(9):3497–506.10.1021/mp4003333 ↗
87. Cui C, Xue YN, Wu M, Zhang Y, Yu P, Liu L, et al. Cellular uptake, intracellular trafficking, and antitumor efficacy of doxorubicin-loaded reduction-sensitive micelles. Biomaterials. 2013;34(15):3858–69.10.1016/j.biomaterials.2013.01.101 ↗
88. Nelemans LC, Gurevich L. Drug delivery with polymeric nanocarriers-cellular uptake mechanisms. Mater (Basel). 2020;13(2):366.10.3390/ma13020366 ↗
89. Chen T, He B, Tao J, He Y, Deng H, Wang X, et al. Application of Forster Resonance Energy Transfer (FRET) technique to elucidate intracellular and in vivo biofate of nanomedicines. Adv Drug Deliv Rev. 2019;143:177–205.10.1016/j.addr.2019.04.009 ↗
90. Rapoport N, Marin A, Luo Y, Prestwich GD, Muniruzzaman MD. Intracellular uptake and trafficking of Pluronic micelles in drug-sensitive and MDR cells: Effect on the intracellular drug localization. J Pharm Sci. 2002;91(1):157–70.10.1002/jps.10006 ↗
91. Pepić I, Lovrić J, Filipović-Grčić J. How do polymeric micelles cross epithelial barriers? Eur J Pharm Sci. 2013;50(1):42–55.10.1016/j.ejps.2013.04.012 ↗
92. Yokoyama M, Fukushima S, Uehara R, Okamoto K, Kataoka K, Sakurai Y, et al. Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor. J Control Rel. 1998;50(1–3):79–92.10.1016/S0168-3659(97)00115-6 ↗
93. Zheng X, Xie JZ, Zhang X, Sun WT, Zhao HY, Li YT, et al. An overview of polymeric nanomicelles in clinical trials and on the market. Chin Chem Lett. 2021;32(1):243–57.10.1016/j.cclet.2020.11.029 ↗
94. Kim S, Shi Y, Kim JY, Park K, Cheng JX. Overcoming the barriers in micellar drug delivery: Loading efficiency, in vivo stability, and micelle-cell interaction. Expert Opin Drug Deliv. 2010;7(1):49–62.10.1517/17425240903380446 ↗
95. Cabral H, Matsumoto Y, Mizuno K, Chen Q, Murakami M, Kimura M, et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol. 2011;6(12):815–23.10.1038/nnano.2011.166 ↗
96. Huang K, Ma H, Liu J, Huo S, Kumar A, Wei T, et al. Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo. ACS Nano. 2012;6(5):4483–93.10.1021/nn301282m ↗
97. Ma XW, Wu YY, Jin SB, Tian Y, Zhang XN, Zhao YL, et al. Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment. Acs Nano. 2011;5(11):8629–39.10.1021/nn202155y ↗
98. Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. Nanocarriers as an emerging platform for cancer therapy. Nature Nanotech. 2007;2:751–60.10.1038/nnano.2007.387 ↗
99. Greish K. Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting. In: Grobmyer S, Moudgil B, editors. Cancer Nanotechnology. Methods in Molecular Biology, vol. 624. Humana Press; 2010. p. 25–37.10.1007/978-1-60761-609-2_3 ↗
100. Movassaghian S, Merkel OM, Torchilin VP. Applications of polymer micelles for imaging and drug delivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015;7(5):691–707.10.1002/wnan.1332 ↗