Importance and health hazards of nanoparticles used in the food industry
Source abstract
Abstract
Abstract Nanoparticles are considered magic bullets because of their unique properties. Nowadays, the use of nanoparticles has emerged in almost every field of science and technology, owing to its potential of revolutionizing specific fields. In the field of food science and technology, the use of nanoparticles is being studied in diverse areas, starting with the harvesting of crops up to final food consumption. With the increased usage of nanoparticles in day-to-day life, concern over their safety has arisen in everyone’s mind. There is an imbalance between the increase in research to identify new nanoparticle applications and their safety, and this has triggered pressure on scientists to identify the possible effects of nanoparticles on human health. There are numerous studies on the use of nanotechnology in food and the effect of nanoparticles on human health, but there is a vacuum in the literature in terms of the combined analysis of such studies. This review is an attempt to present and analyze different studies on the use and the safety of nanoparticles in food.
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Research context
OpenAlex topics: Nanoparticles: synthesis and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Division of Food Technology , Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir , Kashmir 190025 , India
Department of Biotechnology , Institute of Engineering and Technology, Bundelkhand University , Jhansi, U.P. 284128 , India
Department of Bioengineering , Integral University , Lucknow, U.P. 226026 , India
Department of Post-Harvest Engineering and Technology , Aligarh Muslim University , Aligarh, U.P. 202002 , India
References (100+)
Show source-provided references
1. Scrinis G, Lyons K. The emerging nano-corporate paradigm, nanotechnology and the transformation of nature, food and agri-food systems. Int. J. Sociol. Agric. Food 2007, 15, 22–44.
2. Neethirajan S, Jayas DS. Nanotechnology for the food and bioprocessing industries. Food Bioprocess. Technol. 2011, 2010, 39–47.10.1007/s11947-010-0328-2 ↗
3. Roholla Mousavi S, Rezaei M. Nanotechnology in agriculture and food production. J. Appl. Environ. Biol. Sci. 2011, 1, 414–419.
4. Srilatha B. Nanotechnology in agriculture. J. Nanomed. Nanotechnol. 2011, 02, 1–5.10.4172/2157-7439.1000123 ↗
5. Ramsden JJ. Nanotechnology in agriculture. Ann. Agr. Sci. 2012, 10, 1–7.
6. Durán N, Marcato PD. Nanobiotechnology perspectives. Role of nanotechnology in the food industry, a review. Int. J. Food Sci. Technol. 2013, 48, 1127–1134.10.1111/ijfs.12027 ↗
7. Chen H, Yada R. Nanotechnologies in agriculture. New tools for sustainable development. Trends Food Sci. Technol. 2011, 22, 585–594.10.1016/j.tifs.2011.09.004 ↗
8. Sanguansri P, Augustin MA. Nanoscale materials development – a food industry perspective. Trends Food Sci. Technol. 2006, 17, 547–556.10.1016/j.tifs.2006.04.010 ↗
9. Duncan TV. Applications of nanotechnology in food packaging and food safety. Barrier materials, antimicrobials and sensors. J. Colloid Interface Sci. 2011, 363, 1–24.10.1016/j.jcis.2011.07.017 ↗
10. Parisi C, Vigani M, Rodríguez-Cerezo E. Agricultural nanotechnologies. What are the current possibilities? Nano Today 2014, 10, 124–127.10.1016/j.nantod.2014.09.009 ↗
11. Frewer LJ, Bergmann K, Brennan M, Lion R, Meertens R, Rowe G, Siegrist M, Vereijken C. Consumer response to novel agri-food technologies. Implications for predicting consumer acceptance of emerging food technologies. Trends Food Sci. Technol. 2011, 22, 442–456.10.1016/j.tifs.2011.05.005 ↗
12. Matin AH, Goddard E, Vandermoere F, Blanchemanche S, Bieberstein A, Marette S, Roosen J. Do environmental attitudes and food technology neophobia affect perceptions of the benefits of nanotechnology? Int. J. Consum. Stud. 2012, 36, 149–157.10.1111/j.1470-6431.2011.01090.x ↗
13. Belli B. Eating nano. Our food supply is not nearly as safe as we would like to believe. Environ. Mag. 2012. https://emagazine.com/eating-nano/
14. Bumbudsanpharoke N, Ko S. Nano-food packaging. An overview of market, migration research, and safety regulations. J. Food Sci. 2015, 80, R910–R923.10.1111/1750-3841.12861 ↗
15. Sozer N, Kokini JL. Nanotechnology and its applications in the food sector. Trends Biotechnol. 2009, 27, 82–89.10.1016/j.tibtech.2008.10.010 ↗
16. Silvestre C, Duraccio D, Cimmino S. Food packaging based on polymer nanomaterials. Prog. Polym. Sci. 2011, 36, 1766–1782.10.1016/j.progpolymsci.2011.02.003 ↗
17. Ravichandran R. Nanotechnology applications in food and food processing, innovative green approaches, opportunities and uncertainties for global market. Int. J. Green Nanotechnol. Phys. Chem. 2010, 1, P72–P96.10.1080/19430871003684440 ↗
18. Weiss J, Takhistov P, McClements DJ. Functional materials in food nanotechnology. J. Food Sci. 2006, 71, R107–R116.10.1111/j.1750-3841.2006.00195.x ↗
19. Rashidi L, Khosravi-Darani K. The applications of nanotechnology in food industry. Crit. Rev. Food Sci. Nutr. 2011, 51, 723–730.10.1080/10408391003785417 ↗
20. Tharanathan RN. Biodegradable films and composite coatings. Past, present and future. Trends Food Sci. Technol. 2003, 14, 71–78.10.1016/S0924-2244(02)00280-7 ↗
21. Cha DS, Chinnan MS. Biopolymer-based antimicrobial packaging. A review. Crit. Rev. Food Sci. Nutr. 2004, 44, 223–237.10.1080/10408690490464276 ↗
22. Zhao X, Hilliard LR, Mechery SJ, Wang Y, Bagwe RP, Jin S, Tan W. A rapid bioassay for single bacterial cell quantitation using bioconjugated nanoparticles. Proc. Natl. Acad. Sci. 2004, 101, 15027–15032.10.1073/pnas.0404806101 ↗
23. Kriegel C, Kit KM, McClements DJ, Weiss J. Influence ofsurfactant type and concentration on electro spinning of chitosan-poly (ethylene oxide) blend nano fibers. Food Biophys. 2006, 4, 213–228.10.1007/s11483-009-9119-6 ↗
24. Damm C, Münstedt H, Rösch A. Long-term antimicrobial polyamide 6/silver-nanocomposites. J. Mater. Sci. 2007, 42, 6067–6073.10.1007/s10853-006-1158-5 ↗
25. Coma V. Bioactive packaging technologies for extended shelf life of meat-based products. Meat Sci. 2008, 78, 90–103.10.1016/j.meatsci.2007.07.035 ↗
26. Bhattacharya S, Jang J, Yang L, Akin D, Bashir R. Biomems and nanotechnology-based approaches for rapid detection of biological entities. J. Rapid Methods Autom. Microbiol. 2007, 15, 1–32.10.1111/j.1745-4581.2007.00073.x ↗
27. Neethirajan S, Gordon R, Wang L. Potential of silica bodies (phytoliths) for nanotechnology. Trends Biotechnol. 2009, 15, 1–32.
28. Ruengruglikit C, Kim H-C, Miller RD, Huang Q. Fabrication of nanoporous oligonucleotide microarray for pathogen detection and identification. Am. Chem. Soc. 2004, 45, 526.
29. Valdés MG, Valdés González AC, García Calzón JA, Díaz-García ME. Analytical nanotechnology for food analysis. Microchim. Acta 2009, 166, 1–19.10.1007/s00604-009-0165-z ↗
30. Hossain MK, Ghosh SC, Boontongkong Y, Thanachayanont C, Dutta J. Growth of zinc oxide nanowires and nanobelts for gas sensing applications. Sens. Lett. 2005, 23, 27–30.10.4028/www.scientific.net/JMNM.23.27 ↗
31. Abdullah AH, Adom AH, Md. Shakaff AY, Ahmad MN, Saad MA, Tan ES, Fikri NA, Markom MA, Zakaria A. Electronic nose system for Ganoderma detection. Sens. Lett. 2011, 9, 353–358.10.1166/sl.2011.1479 ↗
32. Rivas GA, Miscoria SA, Desbrieres J, Barrera GD. New biosensing platforms based on the layer-by-layer self-assembling of polyelectrolytes on Nafion/carbon nanotubes-coated glassy carbon electrodes. Talanta 2007, 71, 270–275.10.1016/j.talanta.2006.03.056 ↗
33. Wen H-W, Borejsza-Wysocki W, DeCory TR, Baeumner AJ, Durst RA. A novel extraction method for peanut allergenic proteins in chocolate and their detection by a liposome-based lateral flow assay. Eur. Food Res. Technol. 2005, 221, 564–569.10.1007/s00217-005-1202-8 ↗
34. Baeumner A. Nanosensors identify pathogens in food. Food Technol. 2004, 58, 51–55.
35. Mabeck JT, Malliaras GG. Chemical and biological sensors based on organic thin-film transistors. Anal. Bioanal. Chem. 2005, 384, 343–353.10.1007/s00216-005-3390-2 ↗
36. Horner SR, Mace CR, Rothberg LJ, Miller BL. A proteomic biosensor for enteropathogenic E. coli. Biosens. Bioelectron. 2006, 21, 1659–1663.10.1016/j.bios.2005.07.019 ↗
37. Fu J, Park B, Siragusa G, Jones L, Tripp R, Zhao Y, Cho Y-J. An Au/Si hetero-nanorod-based biosensor for Salmonella detection. Nanotechnology 2008, 19, 155502.10.1088/0957-4484/19/15/155502 ↗
38. Vinayaka AC, Basheer S, Thakur MS. Bioconjugation of CdTe quantum dot for the detection of 2,4-dichlorophenoxyacetic acid by competitive fluoroimmunoassay based biosensor. Biosens. Bioelectron. 2009, 24, 1615–1620.10.1016/j.bios.2008.08.042 ↗
39. Ai K, Liu Y, Lu L. Hydrogen-bonding recognition-induced color change of gold nanoparticles for visual detection of melamine in raw milk and infant formula. J. Am. Chem. Soc. 2009, 131, 9496–9497.10.1021/ja9037017 ↗
40. Gutiérrez-Tauste D, Domènech X, Casañ-Pastor N, Ayllón JA. Characterization of methylene blue/TiO2 hybrid thin films prepared by the liquid phase deposition (LPD) method. Application for fabrication of light-activated colorimetric oxygen indicators. J. Photochem. Photobiol. A Chem. 2007, 187, 45–52.10.1016/j.jphotochem.2006.09.011 ↗
41. Luechinger NA, Loher S, Athanassiou EK, Grass RN, Stark WJ. Highly sensitive optical detection of humidity on polymer/metal nanoparticle hybrid films. Langmuir 2007, 23, 3473–3477.10.1021/la062424y ↗
42. von Bültzingslöwen C, McEvoy AK, McDonagh C, MacCraith BD, Klimant I, Krause C, Wolfbeis OS. Sol-gel based optical carbon dioxide sensor employing dual luminophore referencing for application in food packaging technology. Analyst 2002, 127, 1478–1483.10.1039/B207438A ↗
43. Fornara A, Johansson P, Petersson K, Gustafsson S, Qin J, Olsson E, Ilver D, Krozer A, Muhammed M, Johansson C. Tailored magnetic nanoparticles for direct and sensitive detection of biomolecules in biological samples. Nano Lett. 2008, 8, 3423–3428.10.1021/nl8022498 ↗
44. Graveland-Bikker JF, de Kruif CG. Unique milk protein based nanotubes. Food and nanotechnology meet. Trends Food Sci. Technol. 2006, 17, 196–203.10.1016/j.tifs.2005.12.009 ↗
45. Seoktae K, Mathieu P, Lisa D P, Menachem E. Single-walled carbon nanotubes exhibit strong antimicrobial activity. Langmuir 2007, 23, 8670–8673.10.1021/la701067r ↗
46. Cheng Y, Liu Y, Huang J, Li K, Xian Y, Zhang W, Jin L. Amperometric tyrosinase biosensor based on Fe3O4 nanoparticles-coated carbon nanotubes nanocomposite for rapid detection of coliforms. Electrochim. Acta 2009, 54, 2588–2594.10.1016/j.electacta.2008.10.072 ↗
47. Lerner MB, Goldsmith BR, McMillon R, Dailey J, Pillai S, Singh SR, Johnson ATC. A carbon nanotube immunosensor for Salmonella. AIP Adv. 2011, 1, 042127.10.1063/1.3658573 ↗
48. Yang J-Y, Li Y, Chen S-M, Lin K-C. Fabrication of a cholesterol biosensor based on cholesterol oxidase and multiwall carbon nanotube hybrid composites. Int. J. Electrochem. Sci. 2011, 6, 2223–2234.
49. Yu Z, Xiaojun Z, Xiaohua L, Jinquan Y, Kangbing W. Multi-wall carbon nanotube film-based electrochemical sensor for rapid detection of Ponceau 4R and Allura Red. Food Chem. 2010, 122, 909–913.10.1016/j.foodchem.2010.03.035 ↗
50. Zhirong M, Yafen Z, Faqiong Z, Fei X, Gaiping G, Baizhao Z. Sensitive voltammetric determination of Sudan I in food samples by using Gemini surfactant-ionic liquid-multiwalled carbon nanotube composite film modified glassy carbon electrodes. Food Chem. 2010, 121, 233–237.10.1016/j.foodchem.2009.11.077 ↗
51. Chen W, Tao X, Xue P, Cheng X. Enhanced mechanical properties and morphological characterizations of poly(vinyl alcohol)-carbon nanotube composite films. Appl. Surf. Sci. 2005, 252, 1404–1409.10.1016/j.apsusc.2005.02.138 ↗
52. Ruoff RS, Lorents DC. Mechanical and thermal properties of carbon nanotubes. Carbon 1995, 33, 925–930.10.1016/0008-6223(95)00021-5 ↗
53. Ipsen R, Otte J. Self-assembly of partially hydrolysed α-lactalbumin. Biotechnol. Adv. 2007, 25, 602–605.10.1016/j.biotechadv.2007.07.006 ↗
54. Shah RY, Prajapati PN, Agrawal YK. Anticounterfeit packaging technologies. J. Adv. Pharm. Technol. Res. 2010, 1, 368–373.10.4103/0110-5558.76434 ↗
55. Otles S, Yalcin B. Nano-biosensors as new tool for detection of food quality and safety. LogForum 2010, 6, 67–69.
56. Lu J, Bowles M. How will nanotechnology affect agricultural supply chains? Int. Food Agribus. Manag. Rev. 2013, 16, 21–42.
57. Nam J-M, Thaxton CS, Mirkin CA. Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science 2003, 301, 1884–1886.10.1126/science.1088755 ↗
58. Zhang H, Elghanian R, Demers L, Amro N, Disawal S, Cruchon-Dupeyrat S. Direct-write nanolithography method of transporting ink with an elastomeric polymer coated nanoscopic tip to form a structure having internal hollows on a substrate. 2009. US7491422B2, US Grant patent.
59. Li Y, Cu YTH, Luo D. Multiplexed detection of pathogen DNA with DNA-based fluorescence nanobarcodes. Nat. Biotechnol. 2005, 23, 885–889.10.1038/nbt1106 ↗
60. Semo E, Kesselman E, Danino D, Livney YD. Casein micelle as a natural nano-capsular vehicle for nutraceuticals. Food Hydrocoll. 2007, 21, 936–942.10.1016/j.foodhyd.2006.09.006 ↗
61. Afroz M, Karthikeyan P, Ahmed P, Kumar U. Application of nanotechnology in food and dairy processing. An overview. Pak. J. Food Sci. 2012, 22, 23–31.
62. Keogh MK, O’Kennedy BT, Kelly J, Auty MA, Kelly PM, Fureby A, Haahr A-M. Stability to oxidation of spray-dried fish oil powder microencapsulated using milk ingredients. J. Food Sci. 2001, 66, 217–224.10.1111/j.1365-2621.2001.tb11320.x ↗
63. Chaudhry Q, Scotter M, Blackburn J, Ross B, Boxall A, Castle L, Aitken R, Watkins R. Applications and implications of nanotechnologies for the food sector. Food Addit. Contam. A 2008, 25, 241–258.10.1080/02652030701744538 ↗
64. O’Riordan K, Andrews D, Buckle K, Conway P. Evaluation of microencapsulation of a Bifidobacterium strain with starch as an approach to prolonging viability during storage. J. Appl. Microbiol. 2001, 91, 1059–1066.10.1046/j.1365-2672.2001.01472.x ↗
65. Kuan C-Y, Yee-Fung W, Yuen K-H, Liong M-T. Nanotech. Propensity in foods and bioactives. Crit. Rev. Food Sci. Nutr. 2012, 52, 55–71.10.1080/10408398.2010.494259 ↗
66. Silva HD, Cerqueira MA, Souza BWS, Ribeiro C, Avides MC, Quintas MAC, Coimbra JSR, Carneiro-da-Cunha MG, Vicente AA. Nanoemulsions of β-carotene using a high-energy emulsification-evaporation technique. J. Food Eng. 2011, 102, 130–135.10.1016/j.jfoodeng.2010.08.005 ↗
67. Mozafari MR, Flanagan J, Matia-Merino L, Awati A, Omri A, Suntres ZE, Singh H. Recent trends in the lipid-based nanoencapsulation of antioxidants and their role in foods. J. Sci. Food Agric. 2006, 86, 2038–2045.10.1002/jsfa.2576 ↗
68. Khosravi-Darani K, Pardakhty A, Honarpisheh H, Rao VSNM, Mozafari MR. The role of high-resolution imaging in the evaluation of nanosystems for bioactive encapsulation and targeted nanotherapy. Micron 2007, 38, 804–818.10.1016/j.micron.2007.06.009 ↗
69. McClements DJ, Rao J. Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity. Crit. Rev. Food Sci. Nutr. 2011, 51, 285–330.10.1080/10408398.2011.559558 ↗
70. Gu YS, Decker AE, McClements DJ. Production and characterization of oil-in-water emulsions containing droplets stabilized by multilayer membranes consisting of β-lactoglobulin, ι-carrageenan and gelatin. Langmuir 2005, 21, 5752–5760.10.1021/la046888c ↗
71. Gould-Fogerite S, Mannino RJ, Margolis D. Cochleate delivery vehicles. Applications to gene therapy. Drug Deliv. Technol. 2007, 3, 40–47.
72. Garti N, Benichou A. Double emulsions for controlled-release applications. Progress and trends. In Encyclopedic Handbook of Emulsion Technology, Sjoblom, J, Ed., CRC Press/Taylor & Francis Group: Boca Raton, 2001.10.1201/9781420029581.ch17 ↗
73. Wang X, Jiang Y, Wang Y-W, Huang M-T, Ho C-T, Huang Q. Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions. Food Chem. 2008, 108, 419–424.10.1016/j.foodchem.2007.10.086 ↗
74. Engeman CD, Baumgartner L, Carr BM, Fish AM, Meyerhofer JD, Satterfield TA, Holden PA, Harthorn BH. Governance implications of nanomaterials companies’ inconsistent risk perceptions and safety practices. J. Nanopart. Res. 2012, 14, 749.10.1007/s11051-012-0749-0 ↗
75. Warheit DB. Debunking some misconceptions about nanotoxicology. Nano Lett. 2010, 10, 4777–4782.10.1021/nl103432w ↗
76. Krug HF, Wick P. Nanotoxicology. An interdisciplinary challenge. Angew. Chem. Int. Ed. 2011, 50, 1260–1278.10.1002/anie.201001037 ↗
77. Daniel M-C, Astruc D. Gold nanoparticles, assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem. Rev. 2004, 104, 293–346.10.1021/cr030698+ ↗
78. Gojova A, Guo B, Kota RS, Rutledge JC, Kennedy IM, Barakat AI. Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles. Effect of particle composition. Environ. Health Perspect. 2007, 115, 403–409.10.1289/ehp.8497 ↗
79. Geiser M, Rothen-Rutishauser B, Kapp N, Schürch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ. Health Perspect. 2005, 113, 1555–1560.10.1289/ehp.8006 ↗
80. Teeguarden JG, Hinderliter PM, Orr G, Thrall BD, Pounds JG. Particokinetics in vitro, dosimetry considerations for in vitro nanoparticle toxicity assessments. Toxicol. Sci. 2007, 95, 300–312.10.1093/toxsci/kfl165 ↗
81. Oberdorster G. Safety assessment for nanotechnology and nanomedicine, concepts of nanotoxicology. J. Intern. Med. 2010, 267, 89–105.10.1111/j.1365-2796.2009.02187.x ↗
82. Editorial. The dose makes the poison. Nat. Nanotechnol. 2011, 6, 329.10.1038/nnano.2011.87 ↗
83. Lynch I, Dawson KA. Protein-nanoparticle interactions. Nano Today 2008, 3, 40–47.10.1016/S1748-0132(08)70014-8 ↗
84. Deng ZJ, Liang M, Monteiro M, Toth I, Minchin RF. Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation. Nat. Nanotechnol. 2011, 6, 39–44.10.1038/nnano.2010.250 ↗
85. Oberdörster G, Stone V, Donaldson K. Toxicology of nanoparticles. A historical perspective. Nanotoxicology 2007, 1, 2–25.10.1080/17435390701314761 ↗
86. Ju-Nam Y, Lead JR. Manufactured nanoparticles. An overview of their chemistry, interactions and potential environmental implications. Sci. Total Environ. 2008, 400, 396–414.10.1016/j.scitotenv.2008.06.042 ↗
87. Chidambaram M, Krishnasamy K. Nanotoxicology. Toxicity of engineered nanoparticles and approaches to produce safer nanotherapeutics. Int. J. Pharm. Sci. 2012, 2, 117–124.
88. Donaldson K, Aitken R, Tran L, Stone V, Duffin R, Forrest G, Alexander A. Carbon nanotubes. A review of their properties in relation to pulmonary toxicology and workplace safety. Toxicol. Sci. 2006, 92, 5–22.10.1093/toxsci/kfj130 ↗
89. Stone V, Donaldson K, Signs of stress. Nat. Nanotechnol. 2006, 1, 23–24.10.1038/nnano.2006.69 ↗
90. Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett. 2006, 6, 1794–1807.10.1021/nl061025k ↗
91. Brown DM, Donaldson K, Borm PJ, Schins RP, Dehnhardt M, Gilmour P, Jimenez LA, Stone V. Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. Am. J. Physiol. Cell. Mol. Physiol. 2004, 286, L344–L353.10.1152/ajplung.00139.2003 ↗
92. Roiter Y, Ornatska M, Rammohan AR, Balakrishnan J, Heine DR, Minko S. Interaction of nanoparticles with lipid membrane. Nano Lett. 2008, 8, 941–944.10.1021/nl080080l ↗
93. Wang B, Zhang L, Bae SC, Granick S. Nanoparticle-induced surface reconstruction of phospholipid membranes. Proc. Natl. Acad. Sci. USA 2008, 105, 18171–18175.10.1073/pnas.0807296105 ↗
94. Conner SD, Schmid SL. Regulated portals of entry into the cell. Nature 2003, 422, 37–44.10.1038/nature01451 ↗
95. Krewski D, Acosta D, Andersen M, Anderson H, Bailar JC, Boekelheide K, Brent R, Charnley G, Cheung VG, Green S, Kelsey KT, Kerkvliet NI, Li AA, McCray L, Meyer O, Patterson RD, Pennie W, Scala RA, Solomon GM, Stephens M, Yager J, Zeise L; Staff of Committee on Toxicity Testing and Assessment of Environmental Agents. Toxicity testing in the 21st century. A vision and a strategy. J. Toxicol. Environ. Health B 2010, 13, 51–138.10.1080/10937404.2010.483176 ↗
96. Nel A, Xia T, Meng H, Wang X, Lin S, Ji Z, Zhang H. Nanomaterial toxicity testing in the 21st century, use of a predictive toxicological approach and high-throughput screening. Acc. Chem. Res. 2012, 46, 607–621.10.1021/ar300022h ↗
97. Fourches D, Pu D, Tassa C, Weissleder R, Shaw SY, Mumper RJ, Tropsha A. Quantitative nanostructure-activity relationship modeling. ACS Nano 2010, 4, 5703–5712.10.1021/nn1013484 ↗
98. Puzyn T, Rasulev B, Gajewicz A, Hu X, Dasari TP, Michalkova A, Hwang H-M, Toropov A, Leszczynska D, Leszczynski J. Using nano-QSAR to predict the cytotoxicity of metal oxide nanoparticles. Nat. Nanotechnol. 2011, 6, 175–178.10.1038/nnano.2011.10 ↗
99. Kalpana Sastry R, Anshul S, Rao NH. Nanotechnology in food processing sector – an assessment of emerging trends. J. Food Sci. Technol. 2013, 50, 831–841.10.1007/s13197-012-0873-y ↗
100. Dudefoi W, Moniz K, Allen-Vercoe E, Ropers M-H, Walker VK. Impact of food grade and nano-TiO2 particles on a human intestinal community. Food Chem. Toxicol. 2017, 106, 242–249.10.1016/j.fct.2017.05.050 ↗