Toxicity assessment of nanoparticles in various systems and organs
Source abstract
Abstract
Abstract In the past decades, much attention has been paid to toxicity assessment of nanoparticles prior to clinical and biological applications. Whilein vitrostudies have been increasing constantly,in vivostudies of nanoparticles have not established a unified system until now. Predictive models and validated standard methods are imperative. This review summarizes the current progress in approaches assessing nanotoxicity in main systems, including the hepatic and renal, gastrointestinal, pulmonary, cardiovascular, nervous, and immune systems. Histopathological studies and specific functional examinations in each system are elucidated. Related injury mechanisms are also discussed.
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Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Heavy Metal Exposure and Toxicity
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China
West China School of Stomatology, Sichuan University, Chengdu, China
Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region, Chengdu, China
References (100+)
Show source-provided references
1. Nickel nanoparticles exposure and reproductive toxicity in healthy adult rats10.3390/ijms151121253 ↗
2. One - month persistence of inflammation and alteration of fibrotic marker and cytoskeletal proteins in rat kidney after Cd - doped silica nanoparticle instillation10.1016/j.toxlet.2014.11.021 ↗
3. Spatial learning and memory function - related gene expression in the hippocampus of mouse exposed to nanoparticle - rich diesel exhaust10.1016/j.neuro.2008.09.007 ↗
4. Effect of glycyrrhizic acid on titanium dioxide nanoparticles - induced hepatotoxicity in rats10.1016/j.cbi.2014.07.001 ↗
5. A review of the in vivo and in vitro toxicity of silver and gold particulates : particle attributes and biological mechanisms responsible for the observed toxicity10.3109/10408440903453074 ↗
6. Nervous system effects of dissolved and nanoparticulate cadmium in rats in subacute exposure10.1002/jat.1664 ↗
7. Significant effect of size on thein vivobiodistribution of gold composite nanodevices in mouse tumor models10.1016/j.nano.2007.09.001 ↗
8. Toxicity testing of sildenafil base loaded liposomes in in vitro and ex vivo models for pulmonary application Lipid Sci
9. The effects of chard ( Beta vulgarisL var cicla ) extract on the kidney tissue serum urea and creatinine levels of diabetic rats10.1002/ptr.1041 ↗
10. Toxicity and inflammatory response in Swiss albino mice after intraperitoneal and oral administration of polyurethane nanoparticles10.1016/j.toxlet.2016.01.018 ↗
11. Toxicological effects of cationic nanobubbles on the liver and kidneys : biomarkers for predicting the risk10.1016/j.fct.2012.07.005 ↗
12. Toxicological effects of titanium dioxide nanoparticles : a review of in vitro mammalian studies
13. Acute toxicity and pharmacokinetics of nm - sized PEG - coated gold nanoparticles10.1016/j.taap.2008.12.023 ↗
14. Mind your P s and Q s : the coming of age of semiconducting polymer dots and semiconductor quantum dots in biological applications10.1016/j.copbio.2014.11.006 ↗
15. Control of nanoparticle penetration into biofilms through surface design10.1039/C4CC07737G ↗
16. Reproductive toxicity of nanomaterials
17. Long - term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles10.1093/toxsci/70.1.86 ↗
18. Copper - induced changes in reproductive functions : in vivoandin vitroeffects10.33549/physiolres.933063 ↗
19. Development of a short - term inhalation test in the rat using nano - titanium dioxide as a model substance10.1080/08958370802361057 ↗
20. Susceptibility of young and adult rats to the oral toxicity of titanium dioxide nanoparticles10.1002/smll.201201185 ↗
21. Physicochemical characterization of sildenafil - loaded solid lipid nanoparticle dispersions SLN for pulmonary application10.1016/j.ijpharm.2014.09.031 ↗
22. The combined toxicological effects of titanium dioxide nanoparticles and bisphenol A on zebrafish embryos10.1186/1556-276X-9-406 ↗
23. Nanoparticle induced platelet aggregation and vascular thrombosis10.1038/sj.bjp.0706386 ↗
24. Current understanding of interactions between nanoparticles and the immune system10.1016/j.taap.2015.12.022 ↗
25. Modeling approaches for characterizing and evaluating environmental exposure to engineered nanomaterials in support of risk - based decision making10.1021/es302749u ↗
26. Induction of inflammation DNA damage and apoptosis in rat heart after oral exposure to zinc oxide nanoparticles and the cardioprotective role of α - lipoic acid and vitamin E10.1055/s-0033-1334923 ↗
27. Upconverting nanoparticles : a versatile platform for wide - field two - photon microscopy and multi - modalin vivoimaging10.1039/C4CS00173G ↗
28. Evaluation of toxic effects of CdTe quantum dots on the reproductive system in adult male mice10.1016/j.biomaterials.2016.04.014 ↗
29. Biodistribution profiling of the chemical modified hyaluronic acid derivatives used for oral delivery system10.1016/j.ijbiomac.2013.11.027 ↗
30. Damaging effects of multi - walled carbon nanotubes on pregnant mice with different pregnancy times10.1038/srep04352 ↗
31. Effects of intraperitoneally injected silver nanoparticles on histological structures and blood parameters in the albino rat
32. Microscopic localization of PEG - liposomes in a rat model of focal infection10.1016/S0168-3659(01)00402-3 ↗
33. Apoptosis induction and histological changes in rat kidney following Cd - doped silica nanoparticle exposure : evidence of persisting effects10.3109/15376516.2013.803270 ↗
34. Silver nanoparticles as a new generation of antimicrobials10.1016/j.biotechadv.2008.09.002 ↗
35. Coenzyme : absorption tissue uptake metabolism and pharmacokinetics Free Radic
36. Antitumor effect and toxicity of free rhodium ( II ) citrate and rhodium ( II ) citrate - loaded maghemite nanoparticles in mice bearing breast cancer10.1186/1477-3155-11-4 ↗
37. Radioprotection in mice following oral administration of WR - PLGA nanoparticles10.1080/09553000802460198 ↗
38. An experimental assessment of toxic potential of nanoparticle preparation of heavy metals in streptozotocin induced diabetes10.1016/j.etp.2013.05.004 ↗
39. The genotype - dependent influence of functionalized multiwalled carbon nanotubes on fetal development10.1016/j.biomaterials.2013.10.027 ↗
40. Toxicity assessment of zinc oxide nanoparticles using sub - acute and sub - chronic murine inhalation models Fibre Toxicol
41. Time course of quartz and TiO particle - induced pulmonary inflammation and neutrophil apoptotic responses in rats10.1080/01902140260426742 ↗
42. Particle size - dependent organ distribution of gold nanoparticles after intravenous administration10.1016/j.biomaterials.2007.12.037 ↗
43. Review of carbon nanotubes toxicity and exposure appraisal of human health risk assessment based on open literature10.3109/10408444.2010.506638 ↗
44. Polymeric nanoparticle technologies for oral drug delivery10.1016/j.cgh.2014.06.018 ↗
45. Hepatotoxicity of sub - nanosized platinum particles in mice
46. Cerium oxide nanoparticles protect gastrointestinal epithelium from radiation - induced damage by reduction of reactive oxygen species and upregulation of superoxide dismutase10.1016/j.nano.2010.01.010 ↗
47. Injected nanoparticles : the combination of experimental systems to assess cardiovascular adverse effects10.1016/j.ejpb.2014.02.001 ↗
48. Toward toxicity testing of nanomaterials in the st century : a paradigm for moving forward Wiley Interdiscip10.1002/wnan.162 ↗
49. Graphite nanoplatelets andCaenorhabditis elegans : insights from an in vivo model10.1021/nl204388p ↗
50. Nanoparticles and neurotoxicity10.3390/ijms12096267 ↗
51. Subchronic toxicity and immunotoxicity of MeO - PEG - poly lactic - co - glycolic acid ) - PEG - OMe triblock copolymer nanoparticles delivered intravenously into rats10.1088/0957-4484/25/24/245705 ↗
52. High throughput screening platform for engineered nanoparticle - mediated genotoxicity using CometChip technology10.1021/nn404871p ↗
53. Effect of potential - dependent potassium uptake on production of reactive oxygen species in rat brain mitochondria Mosc )
54. Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility10.1038/nnano.2010.153 ↗
55. Toxic characteristics of methoxy poly ( ethylene glycol ) / poly ( ε - caprolactone ) nanospheres , in vitroandin vivostudies in the normal mice10.1016/S0142-9612(02)00248-X ↗
56. Aspect ratio plays a role in the hazard potential of CeO nanoparticles in mouse lung and zebrafish gastrointestinal tract10.1021/nn5012754 ↗
57. MR imaging and targeting of a specific alveolar macrophage subpopulation in LPS - induced COPD animal model using antibody - conjugated magnetic nanoparticles10.2147/IJN.S59394 ↗
58. Histopathological evaluation of the toxic effects of zinc oxide ZnO nanoparticles on testicular tissue of NMRI adult mice10.12988/asb.2015.5425 ↗
59. Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse Fibre Toxicol
60. Biodistribution of colloidal gold nanoparticles after intravenous administration : effect of particle size Colloids Surf
61. Antitesticular effect of copper chloride in albino rats10.2131/jts.24.5_393 ↗
62. A computational framework for interspecies pharmacokinetics , exposure and toxicity assessment of gold nanoparticles10.2217/nnm.15.177 ↗
63. High contrastin vitroandin vivophotoluminescence bioimaging using near infrared to near infrared up - conversion in Tm and Yb doped fluoride nanophosphors10.1021/nl802223f ↗
64. Assessing cytotoxicity of ( iron oxide based ) nanoparticles : an overview of different methods exemplified with cationic magnetoliposomes Contrast Media Mol
65. Assessing nanoparticle toxicity10.1146/annurev-anchem-062011-143134 ↗
66. Manganese nanoparticles : impact on non - modulated plant as a potent enhancer in nitrogen metabolism and toxicity study bothin vivoandin vitro10.1021/jf502716c ↗
67. Review on nano toxic effects in living organisms ( mice and zebra fish )
68. In vivoevaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems10.1016/j.nano.2010.02.002 ↗
69. Prenatal exposure to rutile - type alumina - coated titanium dioxide nanoparticles impairs mouse spermatogenesis10.2131/fts.3.67 ↗
70. NK a paclitaxel - incorporating micellar nanoparticle is a more potent radiosensitising agent compared to free paclitaxel10.1038/sj.bjc.6603311 ↗
71. A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes : the contribution of physico - chemical characteristics10.3109/17435390903569639 ↗
72. The effects of silver nanoparticles on oxidative stress and sperm parameters quality in male rats Babol Univ
73. Dendrimer , liposomes , carbon nanotubes and PLGA nanoparticles : one platform assessment of drug delivery potential10.1208/s12249-014-0073-3 ↗
74. Biodistribution of TNF - α - coated gold nanoparticles in an in vivo model system10.2217/nnm.09.21 ↗
75. PM - bound polycyclic aromatic hydrocarbons : biological indicators lung cancer risk of realistic receptors and source - exposure - effect relationship under different source scenarios10.1016/j.chemosphere.2012.02.044 ↗
76. Short - and long - term effects of prenatal exposure to iron oxide nanoparticles : influence of surface charge and dose on developmental and reproductive toxicity10.3390/ijms161226231 ↗
77. Interactions of PLGA nanoparticles with blood components : protein adsorption coagulation activation of the complement system and hemolysis studies10.1039/C5NR00733J ↗
78. - Assessment of PEG on polymeric particles surface , a key step in drug carrier translation10.1016/j.jconrel.2014.04.017 ↗
79. In vivobiodistribution and synergistic toxicity of silica nanoparticles and cadmium chloride in mice10.1016/j.jhazmat.2013.06.040 ↗
80. Application of gold nanoparticles in biomedical and drug delivery Cells Nanomed
81. Comparative pulmonary toxicity assessments of C water suspensions in rats : few differences in fullerene toxicity in vivo in contrast toin vitroprofiles10.1021/nl0710710 ↗
82. Prevention of malathion - induced depletion of cardiac cells mitochondrial energy and free radical damage by a magnetic magnesium - carrying nanoparticle10.3109/15376516.2010.518173 ↗
83. Renal injury and Nrf modulation in mouse kidney following chronic exposure to TiO nanoparticles10.1021/jf402387e ↗
84. Effect of titanium dioxide nanoparticles on the bioavailability metabolism and toxicity of pentachlorophenol in zebrafish larvae10.1016/j.jhazmat.2014.10.039 ↗
85. Imaging and drug delivery using theranostic nanoparticles10.1016/j.addr.2010.08.004 ↗
86. Analytical methods to assess nanoparticle toxicity10.1039/b818082b ↗
87. Enhanced oral bioavailability of salmeterol by loaded PLGA microspheres : preparation , in vitro , and in vivo evaluation10.3109/10717544.2014.909909 ↗
88. - A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks10.1080/10408440600570233 ↗
89. Lipid nanoparticles for brain targeting III Long - term stability andin vivotoxicity10.1016/j.ijpharm.2013.06.037 ↗
90. Pollution level inhalation exposure and lung cancer risk of ambient atmospheric polycyclic aromatic hydrocarbons ( PAHs ) in Taiyuan China10.1016/j.envpol.2012.10.009 ↗
91. Evaluation of maternal toxicity in rats exposed to multi - wall carbon nanotubes during pregnancy10.5620/eht.2011.26.e2011006 ↗
92. Biodistribution of long - circulating PEG - grafted nanocapsules in mice : effects of PEG chain length and density10.1023/A:1012248721523 ↗
93. Polymer - encapsulated metallic nanoparticles as a bridge between homogeneous and heterogeneous catalysis10.1007/s10562-014-1436-9 ↗
94. - silver a review of available data and knowledge gaps in human and environmental risk assessment10.1080/17435390902725914 ↗
95. Nanotoxicity : the growing need forin vivostudy10.1016/j.copbio.2007.11.008 ↗
96. Immunotoxicity assessment of CdSe / ZnS quantum dots in macrophages lymphocytes and BALB / c mice10.1186/s12951-016-0162-4 ↗
97. Nanomaterial toxicity testing in the st century : use of a predictive toxicological approach and high - throughput screening10.1021/ar300022h ↗
98. Changes in small intestinal morphology and digestive enzyme activity with oral administration of copper - loaded chitosan nanoparticles in rats10.1007/s12011-011-9191-x ↗
99. Glycated peptides are associated with proximal tubule dysfunction in type diabetes mellitus
100. labeled gold glyconanoparticles for exploring blood - brain barrier permeability : preparation biodistribution studies and improved brain uptake via neuropeptide conjugation10.1021/ja411096m ↗