Newly Designed Amperometric Biosensor for Hydrogen Peroxide and Glucose Based on Vanadium Sulfide Nanoparticles

In the present work, we describe a facile, green, and template-free solvothermal fabrication of vanadium sulfide (VS2) nanoparticles (NPs) and their application for the electrochemical detection of hydrogen peroxide (H2O2) and glucose. The morphology and composition of as-prepared samples were well-characterized by powder X-ray diffraction, energy-dispersive spectroscopy, transmission electron microscopy, scanning electron microscopy, UV–vis spectroscopy, and Brunauer–Emmett–Teller surface area measurement. Because of their interesting electrochemical responses toward H2O2, a novel nonenzymatic electrochemical sensor for H2O2 and glucose detection has been proposed based on a VS2 NP-modified glassy carbon electrode. The modified electrode showed an excellent electrochemical performance for the selective and sensitive nonenzymatic detection of H2O2 in a broad concentration range of 0.5 μM to 3.0 mM, with a wide linear range of 0.5 μM to 2.5 mM and a lower detection limit of 0.224 μM. The newly developed sensor also displayed high sensitivity (41.96 μA mM–1) toward the detection of glucose with a broad linear range of 0.5 μM to 3 mM. The as-fabricated sensor also showed very high sensitivity, excellent reusability, long-term stability, and negligible interference ability. Moreover, the synthesized NPs were applied for H2O2 and glucose detection in real samples, signifying their potential application in routine H2O2 and glucose analysis. The present study reveals that as-prepared VS2 NPs are promising for electrochemical H2O2 and glucose sensing and other biological applications.