Ultrasensitive microarray bioassays using cyanine5 dye-doped silica nanoparticles
Source abstract
Abstract
Herein we report the use of high brightness Cyanine5-doped silica nanoparticles (NPs) for the detection of antibodies or DNA in microarray bioassays. NP labels showed negligible non-specific binding, greater sensitivity and lower limits of detection when compared to free dye-labelled biomolecules. Moreover, the spotted microarrays used in this study required low NP and antibody concentrations to generate large data sets with improved statistical accuracy. These NPs have significant potential for use in biosensing for disease detection.
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Research context
OpenAlex topics: Advanced Biosensing Techniques and Applications · Advanced biosensing and bioanalysis techniques · Biosensors and Analytical Detection
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References (19)
Show source-provided references
1. 10.1039/c2cc16306c10.1039/c2cc16306c ↗
2. 10.1007/s12274-009-9041-810.1007/s12274-009-9041-8 ↗
3. 10.1021/acs.chemrev.5b0032110.1021/acs.chemrev.5b00321 ↗
4. 10.1163/156856298X0047910.1163/156856298X00479 ↗
5. 10.1039/c1an15017k10.1039/c1an15017k ↗
6. Kelleher S M · Nanotechnology · 2015 · 2610.1088/0957-4484/26/36/365703 ↗
7. 10.1021/nn700370b10.1021/nn700370b ↗
8. 10.1016/j.ab.2004.08.00510.1016/j.ab.2004.08.005 ↗
9. 10.1021/bc100177v10.1021/bc100177v ↗
10. 10.1007/s00216-012-6224-z10.1007/s00216-012-6224-z ↗
11. 10.1016/j.snb.2015.06.11710.1016/j.snb.2015.06.117 ↗
12. 10.1016/j.jcis.2015.05.05110.1016/j.jcis.2015.05.051 ↗
13. 10.1016/0166-6622(90)80273-710.1016/0166-6622(90)80273-7 ↗
14. 10.1016/j.colsurfb.2007.06.01810.1016/j.colsurfb.2007.06.018 ↗
15. 10.1016/j.bios.2009.01.02610.1016/j.bios.2009.01.026 ↗
16. Schott coated slides · 2016
17. The benefits of neutravidin over streptavidin · 2016
18. Thermo Scientific Avidin-Biotin Technical Handbook
19. 10.1039/b719810h10.1039/b719810h ↗