journal article·2020-02-28

Polymer–Mesoporous Silica Nanoparticle Core–Shell Nanofibers as a Dual-Drug-Delivery System for Guided Tissue Regeneration

Chun Xu, Yuxue Cao, Chang Lei, Zhihao Li, Tushar Kumeria, Anand Kumar Meka, Jia Xu, Jingyu Liu, Cheng Yan, Lihua Luo, Ali Khademhosseini, Amirali Popat, Yan He, Qingsong Ye

ACS Applied Nano Materials· Volume 3· Issue 2
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Abstract

Bioactive membranes with growth factors that mimic the physiological microenvironment of periodontal tissues have shown great potential for guided tissue regeneration (GTR). However, the loss of bioactivity and the uncontrolled drug release in conventional membranes limit their efficacy. In addition, membranes with local infection control ability would provide additional benefits to regeneration. In this work, nanoengineered membranes with growth factor and antibiotic delivery capabilities were developed to achieve dual functions for efficient GTR. Mesoporous silica nanoparticles (MSNs) with large pores with the ability to encapsulate and preserve the bioactivity of growth factors were used as the core, and antibiotics were loaded in shell nanofibers with coaxial electrospinning. A sustained release behavior of the growth factor was observed, and the nanoparticle-encapsulated core–shell nanofibers show better ontogenetic regeneration abilities toward bone marrow stromal cells, compared to current commercial Bio-Gide membranes. In addition, the drug-loaded nanocomposite core–shell nanofibers showed excellent antibacterial properties toward Gram-positive, Gram-negative, and multispecies oral bacteria. The MSNs-embedded core–shell nanofiber system provides an attractive strategy to deliver dual drugs for GTR with better performance.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine · Periodontal Regeneration and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Dentistry, The University of Queensland, Brisbane, Queensland 4006, Australia

Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California—Los Angleles, Los Angeles, California 90095, United States

Department of Bioengineering, University of California—Los Angeles, Los Angeles, California 90095, United States

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, Australia

School of Pharmacy, The University of Queensland, Brisbane, Queensland 4102, Australia

School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland 4059, Australia

School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang 325035 China

Institute of Stem Cells and Tissue Engineering, School of Stomatology, Wenzhou Medical University, Wenzhou, 325035 China

Funding

Australian Dental Research Foundation · National Health and Medical Research Council · National Natural Science Foundation of China · University of Queensland · Advance Queensland Women’s Academic Fund

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