Oscillations in the kinetics of ethylcyanoacrylate nanoparticles intended as skin drug carriers

Ethylcyanoacrylate nanoparticles (40–100 nm) were synthesized to act as potential skin drug carriers. A novel multiscale non-linear model, based on an oscillatory mechanism, which includes polymerization, de-polymerization, re-polymerization and cluster dynamics, is shown to fit the kinetics experimental data and it is used to estimate the amount of potentially histotoxic by-products (i.e. residual monomers or very low molecular weight oligomers).