journal article·2024-11-22

Nanoformulation of the Photoactive Cisplatin Prodrug for Combined Photothermal Therapy and Bioimaging

Daniil V. Spector, Vladislav Bykusov, Anastasia Zharova, Ilia Kuzmichev, Yulia A. Isaeva, Evgeny V. Khaydukov, Ekaterina Trifanova, Maxim Stepanov, Alexander S. Erofeev, Petr Gorelkin, Regina Kuanaeva, Vita N. Nikitina, Alexander Dubenskii, Yulia Maksimova, Dmitry Aleksandrovich Skvortsov, Daria Ipatova, Igor A. Rodin, Mikhail F. Vokuev, Alexander G. Martynov, Dmitry Bunin, Vadim S. Pokrovsky, Gulalek Babayeva, Tamara Uskova, Maxim A. Abakumov, Elena K. Beloglazkina, Roman A. Akasov, Olga O. Krasnovskaya

ACS Applied Nano Materials· Volume 7· Issue 22
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Abstract

Cancer phototheranostics is a new mode of precise treatment based on fluorescent and photothermal imaging (PTI), combined with photodynamic (PDT) and photothermal therapy (PTT). Herein, we designed a photoactive Pt(IV) prodrug Pt-1 with BODIPY-based triplet photosensitizer as an axial ligand that exhibits cytotoxic effects through both PDT and photoactivated chemotherapy (PACT). Based on the Pt-1 prodrug, we developed a multifunctional theranostic nanoplatform Pt-NPs with combined PDT/PTT activity, capable of light-induced cisplatin release and suitable for photothermal and fluorescent tumor imaging. Upon 660 nm laser irradiation, Pt-NPs efficiently causes regional hyperpyrexia, with a photothermal conversion efficiency of 42.1%. Synergistically, Pt-NPs acts as a PDT type I agent. In vivo PTI studies have shown bright fluorescence of the CT-26 tumor after intravenous injection of Pt-NPs, indicating accumulation and retention of Pt-NPs in the tumor. This is the first example of PTT/PDT-active NPs based on Pt(IV) prodrug capable of photoinduced release of cisplatin. This strategy of the synergistic light-induced PDT/PTT/PACT action of Pt-NPs provides a new platform for the future design of phototheranostic agents for enhanced tumor treatment and imaging.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Gold and Silver Nanoparticles Synthesis and Applications · Photochromic and Fluorescence Chemistry

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia

V.P. Serbsky National Medical Research Center for Psychiatry and Narcology, Kropotkinsky per. 23, Moscow 119034, Russia

Enikolopov Institute of Synthetic Polymer Materials RAS, Profsoyuznaya St. 70, Moscow 117393, Russia

Moscow Pedagogical State University (MPGU), 29/7 Malaya Pirogovskaya Str., Building 1, Moscow 119991, Russia

Mendeleev University of Chemical Technology of Russia, Miusskaya Ploshchad, 9, Building 1, Moscow 125047, Russia

Moscow Central Research Institute of Dentistry and Maxillofacial Surgery, 16, Timura Frunze Str., Moscow 119991, Russia

National University of Science and Technology (MISIS), Leninskiy Prospect 4, Moscow 119049, Russia

Federal State Budgetary Scientific Institution Geological Institute of the Russian Academy of Sciences, Pyzhevsky per., 7, Building 1, Moscow 119017, Russia

Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninsky pr., 31, Building 4, Moscow 119071, Russia

Blokhin National Medical Research Center of Oncology, Moscow 115478, Russia

Department of Biochemistry, Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow 117198, Russia

Department of Medical Nanobiotechnology, N.I. Pirogov Russian National Research Medical University, Ostrovityanova Str., 1, 6, Moscow 117997, Russia

I.M. Sechenov First Moscow State Medical University, Trubetskaya 8-2, Moscow 119991, Russia

Funding

Russian Science Foundation · Ministry of Science and Higher Education of the Russian Federation

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