In-Lattice Occupied Rare Earth Metal Chalcogenide Nanocomposites as Electrocatalysts for Selective Detection of Promethazine Hydrochloride

This study aims to provide a widely applicable electrochemical sensor for the determination of the first-generation antihistamine, promethazine hydrochloride (PMH), which accounts for its efficacy in treating allergic reactions, motion sickness, and sedating human patients before surgery or medical treatment. Along with its use in clinical settings, it can also induce some undesirable side effects. For safety measures, it is necessary to detect this drug in biological fluids and environmental samples. For this purpose, a one-pot hydrothermal method is used to construct a 0-D CdTe anchored on rod-shaped CeO 2 electrocatalyst-modified GCE for the electrochemical detection of PMH. Various spectroscopic techniques were used to characterize our proposed CdTe-CeO 2 nanocomposite. Further, the electrochemical properties of the CdTe-CeO 2 /GCE sensor were investigated by using EIS and CV techniques. Under an optimized condition, our proposed sensor effectively detects PMH using CV and DPV techniques in a pH-7 medium. As a result, our electrocatalyst provides a higher sensitivity (2.295 μA μM –1 cm –2 ) with a low limit of detection of 0.0037 μM and a wide linear range of 0.001–113.719 μM. Moreover, our proposed sensor exhibits high selectivity and outstanding reproducibility, which indicates that CdTe-CeO 2 /GCE configuration could be a feasible alternative for assessing PMH.