The potential mechanisms and treatment effects of stem cell-derived exosomes in cardiac reengineering
Source abstract
Abstract
Abstract Exosomes are extracellular vesicles of diverse compositions that are secreted by numerous cell types. Exosomes contain significant bioactive components, including lipids, proteins, mRNA, and miRNA. Exosomes play an important role in regulating cellular signaling and trafficking under both normal physiological and pathological circumstances. A multitude of factors, including thermal stress, ribosomal stress, endoplasmic reticulum stress, and oxidative stress influence the concentrations of exosomal mRNA, miRNA, proteins, and lipids. It has been stated that exosomes derived from stem cells (SCs) modulate a range of stresses by preventing or fostering cell balance. Exosomes derived from SCs facilitate recovery by facilitating cross-cellular communication via the transmission of information in the form of proteins, lipids, and other components. For this reason, exosomes are used as biomarkers to diagnose a wide variety of diseases. The focus of this review is the bioengineering of artificial exosomal cargoes. This process encompasses the control and transportation of particular exosomal cargoes, including but not limited to small molecules, recombinant proteins, immune modulators, and therapeutic medications. Therapeutic approaches of this nature have the potential to deliver therapeutic medications precisely to the intended site for the cure of a variety of disorders. Notably, our attention has been directed towards the therapeutic implementations of exosomes derived from SCs in the cure of cardiovascular ailments, including but not limited to ischemic heart disease, myocardial infarction, sepsis, heart failure, cardiomyopathy, and cardiac fibrosis. In general, researchers employ two methodologies when it comes to exosomal bioengineering. This review aims to explain the function of exosomes derived from SCs in the regulation of stress and present a novel therapeutic approach for cardiovascular disorders.
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Research context
OpenAlex topics: Extracellular vesicles in disease
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
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1. Next-generation stem cells—ushering in a new era of cell-based therapies10.1038/s41573-020-0064-x ↗
2. Current concepts on endothelial stem cells definition, location, and markers10.1002/sctm.21-0022 ↗
3. Stem cell-based therapy for human diseases10.1038/s41392-022-01134-4 ↗
4. Stem cells: past, present, and future10.1186/s13287-019-1165-5 ↗
5. Stem cell-derived exosome versus stem cell therapy10.1038/s44222-023-00064-2 ↗
6. Recent developments in isolating methods for exosomes10.3389/fbioe.2022.1100892 ↗
7. Review on strategies and technologies for exosome isolation and purification10.3389/fbioe.2021.811971 ↗
8. Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation10.1016/j.ejpb.2015.10.017 ↗
9. Cell type-specific and common characteristics of exosomes derived from mouse cell lines: yield, physicochemical properties, and pharmacokinetics10.1016/j.ejps.2016.10.009 ↗
10. Bone-a-petite: engineering exosomes towards bone, osteochondral, and cartilage repair10.1002/smll.202101741 ↗
11. Exosomes: large-scale production, isolation, drug loading efficiency, and biodistribution and uptake10.1016/j.jconrel.2022.05.027 ↗
12. New insight into isolation, identification techniques and medical applications of exosomes10.1016/j.jconrel.2019.07.021 ↗
13. Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis10.3390/cells8070727 ↗
14. The biology, function, and biomedical applications of exosomes10.1126/science.aau6977 ↗
15. The therapeutic potential and clinical significance of exosomes as carriers of drug delivery system10.3390/pharmaceutics15010021 ↗
16. Current strategies for exosome cargo loading and targeting delivery10.3390/cells12101416 ↗
17. Challenges and opportunities in exosome research-perspectives from biology, engineering, and cancer therapy10.1063/1.5087122 ↗
18. Exosome: a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications10.2147/IJN.S264498 ↗
19. Hydrogel encapsulation of mesenchymal stem cells and their derived exosomes for tissue engineering10.3390/ijms22020684 ↗
20. Strategies to overcome the main challenges of the use of exosomes as drug carrier for cancer therapy10.1186/s12935-022-02743-3 ↗
21. Advances in exosome-based drug delivery and tumor targeting: from tissue distribution to intracellular fate10.2147/IJN.S281890 ↗
22. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy10.1016/j.biomaterials.2013.11.083 ↗
23. Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells10.1016/j.nano.2015.10.012 ↗
24. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells10.1038/mt.2012.180 ↗
25. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes10.1038/nbt.1807 ↗
26. Embryonic stem cells-derived exosomes endowed with targeting properties as chemotherapeutics delivery vehicles for glioblastoma therapy10.1002/advs.201801899 ↗
27. Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes10.1038/srep10112 ↗
28. Methods for the determination of the purity of exosomes10.2174/1381612825666191206162712 ↗
29. Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers10.1039/C5AN00688K ↗
30. Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics10.1016/j.jconrel.2014.12.041 ↗
31. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines10.1080/20013078.2018.1535750 ↗
32. Updating MISEV: evolving the minimal requirements for studies of extracellular vesicles10.1002/jev2.12182 ↗
33. Host derived exosomes-pathogens interactions: potential functions of exosomes in pathogen infection10.1016/j.biopha.2018.09.174 ↗
34. Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine10.1186/s13287-018-0791-7 ↗
35. Mesenchymal stem cell-derived extracellular vesicles and their therapeutic potential10.1155/2020/8825771 ↗
36. Exosomes derived from human mesenchymal stem cells preserve mouse islet survival and insulin secretion function10.17179/excli2020-2451 ↗
37. Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities10.1186/s13287-021-02378-7 ↗
38. The versatile role of exosomes in human retroviral infections: from immunopathogenesis to clinical application10.1186/s13578-021-00537-0 ↗
39. Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses10.1080/20013078.2017.1359478 ↗
40. Possibility of exosome-based therapeutics and challenges in production of exosomes eligible for therapeutic application10.1248/bpb.b18-00133 ↗
41. Trehalose prevents aggregation of exosomes and cryodamage10.1038/srep36162 ↗
42. Preservation of exosomes at room temperature using lyophilization10.1016/j.ijpharm.2018.10.032 ↗
43. To protect and to preserve: novel preservation strategies for extracellular vesicles10.3389/fphar.2018.01199 ↗
44. Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis10.1186/s12967-015-0417-0 ↗
45. Exosomes derived from human umbilical cord mesenchymal stem cells accelerate cutaneous wound healing by enhancing angiogenesis through delivering angiopoietin-210.1007/s12015-020-09992-7 ↗
46. Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function10.7150/thno.21234 ↗
47. Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a10.1242/jcs.170373 ↗
48. Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for normal and chronic wound healing10.12998/wjcc.v9.i22.6218 ↗
49. Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4/β-catenin pathway10.5966/sctm.2014-0267 ↗
50. HucMSC-exosome mediated-wnt4 signaling is required for cutaneous wound healing10.1002/stem.1771 ↗
51. Adipose mesenchymal stem cell-derived exosomes promote cell proliferation, migration, and inhibit cell apoptosis via Wnt/β-catenin signaling in cutaneous wound healing10.1002/jcb.28376 ↗
52. Chronic wound healing: a review of current management and treatments10.1007/s12325-017-0478-y ↗
53. Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model10.1038/s12276-018-0058-5 ↗
54. Exosomes derived from human bone marrow mesenchymal stem cells stimulated by deferoxamine accelerate cutaneous wound healing by promoting angiogenesis10.1155/2019/9742765 ↗
55. Mesenchymal stem cell-derived exosome microRNA as therapy for cardiac ischemic injury10.1016/j.biopha.2021.112118 ↗
56. MiRNA-sequence indicates that mesenchymal stem cells and exosomes have similar mechanism to enhance cardiac repair10.1155/2017/4150705 ↗
57. Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway10.1186/s13287-020-1563-8 ↗
58. MicroRNA-221/222 mediates ADSC-exosome-induced cardioprotection against ischemia/reperfusion by targeting PUMA and ETS-110.3389/fcell.2020.569150 ↗
59. Exosomes and exosomal miRNAs in cardiovascular protection and repair10.1016/j.vph.2015.02.008 ↗
60. Exosomes in cardiovascular diseases: pathological potential of nano-messenger10.3389/fcvm.2021.767488 ↗
61. Stem cell-derived exosomes prevent aging-induced cardiac dysfunction through a novel exosome/lncRNA MALAT1/NF-κB/TNF-α signaling pathway10.1155/2019/9739258 ↗
62. Bone marrow mesenchymal stem cells-derived exosomal microRNA-185 represses ventricular remolding of mice with myocardial infarction by inhibiting SOCS210.1016/j.intimp.2019.106156 ↗
63. Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction10.1161/CIRCRESAHA.117.305990 ↗
64. LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis10.1186/s13287-019-1522-4 ↗
65. HIF-1α overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis10.1186/s13287-020-01881-7 ↗
66. HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction10.1016/j.mtbio.2021.100171 ↗
67. Myocardial ischaemia-reperfusion injury and cardioprotection in perspective10.1038/s41569-020-0403-y ↗
68. Adipose-derived mesenchymal stem cells-derived exosome-mediated microRNA-342-5p protects endothelial cells against atherosclerosis10.18632/aging.102857 ↗
69. Exosomal miR-25-3p from mesenchymal stem cells alleviates myocardial infarction by targeting pro-apoptotic proteins and EZH210.1038/s41419-020-2545-6 ↗
70. Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine10.1126/scitranslmed.aay1318 ↗
71. Exosomes from induced pluripotent stem cell-derived cardiomyocytes promote autophagy for myocardial repair10.1161/JAHA.119.014345 ↗
72. Exosomes from neuronal stem cells may protect the heart from ischaemia/reperfusion injury via JAK1/2 and gp13010.1111/jcmm.16515 ↗
73. Mesenchymal stem cell-derived exosomal miR-143-3p suppresses myocardial ischemia-reperfusion injury by regulating autophagy10.1016/j.lfs.2021.119742 ↗
74. Bone marrow mesenchymal stem cell-derived exosomes attenuate cardiac hypertrophy and fibrosis in pressure overload induced remodeling10.1007/s11626-020-00481-2 ↗
75. Exosomes secreted by endothelial cells derived from human induced pluripotent stem cells improve recovery from myocardial infarction in mice10.1186/s13287-023-03462-w ↗
76. Isolation of swine bone marrow Lin-/CD45-/CD133 + cells and cardio-protective effects of its exosomes10.1007/s12015-022-10432-x ↗
77. Systemic infusion of expanded CD133(+) cells and expanded CD133(+) cell-derived EVs for the treatment of ischemic cardiomyopathy in a rat model of AMI10.1155/2019/4802578 ↗
78. Sonic hedgehog-modified human CD34+ cells preserve cardiac function after acute myocardial infarction10.1161/CIRCRESAHA.112.266015 ↗
79. Human endothelial progenitor cell-derived exosomes increase proliferation and angiogenesis in cardiac fibroblasts by promoting the mesenchymal-endothelial transition and reducing high mobility group box 1 protein B1 expression10.1089/dna.2017.3836 ↗
80. Exosomal miR-218-5p/miR-363-3p from endothelial progenitor cells ameliorate myocardial infarction by targeting the p53/JMY signaling pathway10.1155/2021/5529430 ↗
81. Exosomal miR-17-5p from human embryonic stem cells prevents pulmonary fibrosis by targeting thrombospondin-210.1186/s13287-023-03449-7 ↗
82. Exosomes derived from induced pluripotent stem cells suppresses M2-type macrophages during pulmonary fibrosis via miR-302a-3p/TET1 axis10.1016/j.intimp.2021.108075 ↗
83. Endothelial progenitor cell-derived exosomes inhibit pulmonary artery smooth muscle cell in vitro proliferation and resistance to apoptosis by modulating the Mitofusin-2 and Ras-Raf-ERK1/2 signaling pathway10.1016/j.ejphar.2023.175725 ↗
84. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury10.1186/s13054-019-2339-3 ↗
85. Exosomes derived from endothelial progenitor cells ameliorate acute lung injury by transferring miR-12610.1016/j.yexcr.2018.06.003 ↗
86. Exosomes secreted by endothelial progenitor cells improve the bioactivity of pulmonary microvascular endothelial cells exposed to hyperoxia in vitro10.21037/atm.2019.05.10 ↗
87. Extracellular vesicles for the treatment of radiation-induced normal tissue toxicity in the lung10.3389/fonc.2020.602763 ↗
88. Cardiac stem cell characteristics in physiological and pathological conditions10.2174/1381612824666180903123817 ↗
89. Functions of mesenchymal stem cells in cardiac repair
90. A new paradigm in cardiac regeneration: the mesenchymal stem cell secretome10.1155/2015/765846 ↗
91. The microRNA regulatory landscape of MSC-derived exosomes: a systems view10.1038/s41598-018-19581-x ↗
92. Carvedilol-responsive microRNAs, miR-199a-3p and −214 protect cardiomyocytes from simulated ischemia-reperfusion injury10.1152/ajpheart.00807.2015 ↗
93. Functional screening identifies miRNAs inducing cardiac regeneration10.1038/nature11739 ↗
94. Bone marrow-or adipose-mesenchymal stromal cell secretome preserves myocardial transcriptome profile and ameliorates cardiac damage following ex vivo cold storage10.1016/j.yjmcc.2021.11.002 ↗
95. The mitochondrial p53 pathway10.1016/j.bbabio.2008.10.005 ↗
96. Cardiomyocyte apoptosis with enhanced expression of P53 and Bax in right ventricle after pulmonary arterial banding10.1016/S0024-3205(99)00322-7 ↗
97. Upregulation of P53 protein in rat heart subjected to a transient occlusion of the coronary artery followed by reperfusion10.2170/jjphysiol.50.159 ↗
98. miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit+ cells to promote proliferation and inhibit apoptosis through a negative feedback loop10.1186/s13287-017-0515-4 ↗
99. LKB1, a protein kinase regulating cell proliferation and polarity10.1016/S0014-5793(03)00642-2 ↗
100. The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells10.1101/gad.12.6.820 ↗