DataVXACS Applied Nano MaterialsPaper
journal article·2023-06-09

Fe Single-Atom Nanozymes for Real-Time Dual Monitoring of H2O2 Released from Living Cells

Yong Zhang, Peng Zhao, Cailin Qiao, Jiaying Zhao, Yiyi Liu, Zhen Huang, Huibo Luo, Changjun Hou, Danqun Huo

ACS Applied Nano Materials· Volume 6· Issue 11
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Source abstract

Abstract

Excessive accumulation of hydrogen peroxide (H 2 O 2 ) in the physiological pool can cause oxidative stress of cells and eventually lead to the occurrence of diseases. Therefore, accurate and real-time detection of H 2 O 2 is of great significance for disease detection and prevention. In this study, an Fe single-atom nanozyme (Fe-SNC) with an Fe-N 4 active center was synthesized, which showed excellent peroxidase-like activity in an acidic environment and amazing electrocatalytic activity in H 2 O 2 reduction reaction. Based on this, we proposed a colorimetric and electrochemical dual-signal detection strategy to real-time monitor H 2 O 2 secreted by living cells. Compared with single-signal response mode, double-signal response mode has higher precision and sensitivity. The results show that the detection range of the colorimetric analysis method is 3–1000 μM and the detection limit is 1.3 μM. The detection range of the electrochemical analysis method is 1–8127 μM, and the detection limit is 0.61 μM. We believe that the dual-signal detection strategy based on Fe-SNC not only provides a way for the ultra-sensitive detection of hydrogen peroxide but also has a broad application prospect in clinical diagnosis.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Advanced biosensing and bioanalysis techniques · Electrochemical sensors and biosensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory for Biorheological Science and Technology of Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400044, PR China

Key Laboratory of Bio-Resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, SeNA Research Institute and Szostak-CDHT Large Nucleic Acids Institute, Chengdu 610000 PR China

Liquor Making Biology Technology and Application of Key Laboratory of Sichuan Province, College of Bioengineering, Sichuan University of Science and Engineering, 188 University Town, Yibin 644000, PR China

Chongqing Key Laboratory of Bio-perception & Intelligent Information Processing, School of Microelectronics and Communication Engineering, Chongqing University, Chongqing 400044, PR China

Funding

Chongqing Science and Technology Commission · Graduate School, Chongqing University · Department of Science and Technology of Sichuan Province · Analytical and Testing Center, Chongqing University · Chongqing Graduate Tutor Team Construction Project

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