journal article·2022-08-26

Size-Tunable Yolk–Shell Gold–Silver Nanostructures for Photothermal Treatment of Multidrug-Resistant Bacteria

Haifeng Zhang, Juan Tan, Xiaoqin Yang, Yanyun Ma, Hongyan Zou, Yi Wang, Pu Zhang, Yiqun Zheng

ACS Applied Nano Materials· Volume 5· Issue 8
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Abstract

Framelike nanostructures consisting of interconnected, ultrathin ridges have attracted wide attention due to their high atomic utilization efficiency among typical hollow architectures but are yet to be comprehensively studied for photothermal applications. Herein, we report a facile synthesis of AuAg yolk–shell cubic nanoframes (YSCNFs) with tunable edge lengths, followed by the exploration of their photothermal conversion and in vitro bacteria-killing performance, together with our endeavors to understand the mechanism fundamentally. By adopting the rationally screened capping agent docosyltrimethylammonium chloride (DCTAC) throughout the stepwise synthesis, sharp cubic edges could be generated and largely reserved, leaving the 5 nm cubic nanoframes well standing. The increase in the cubic edge length leads to the red shift of the major LSPR absorption peak toward the NIR region, and abundant hot-spots appear at the frame corner and core surface according to finite-difference time-domain (FDTD) simulation. The photothermal conversion efficiency of YSCNFs can reach as high as 65.6% when a very low power density of 0.27 W cm–2 is used, which displays a powerful ability in combating multidrug-resistant bacteria. The present study offers a systematic investigation of bimetallic yolk–shell nanoframes including size/morphology control, photothermal properties, mechanism studies, and antibacterial applications, which could be of great value for the rational design of high-efficiency photothermal nanomaterials for services to biomedicine.
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Research context

OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemistry, Chemical Engineering, and Materials, Jining University, Qufu, Shandong 273155, P. R. China

Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, P. R. China

Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. China

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, P. R. China

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P. R. China

Funding

Collaborative Innovation Center of Suzhou Nano Science and Technology · Department of Education of Shandong Province · Soochow University · National Natural Science Foundation of China · Priority Academic Program Development of Jiangsu Higher Education Institutions · Higher Education Discipline Innovation Project · Chongqing Innovation Research Group · Joint International Research Laboratory of Carbon-Based Functional Materials and Devices · Scientific and Technological Innovation Key Project for Construction of Double City Economic Circle in Chengdu-Chongqing Region · Jining University

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