Antibody Conjugation of Fluorescent Nanodiamonds for Targeted Innate Immune Cell Activation
Source abstract
Abstract
BACKGROUND: fluorescent nanodiamonds (FND) are nontoxic, infinitely photostable nanoparticles that emit near-infrared fluorescence and have a modifiable surface allowing for the generation of protein-FND conjugates. FND-mediated immune cell targeting may serve as a strategy to visualize immune cells and promote immune cell activation. METHODS: studies were performed using a breast cancer mouse model. RESULTS: studies demonstrated the targeted immune cell uptake of IgG-gFND, resulting in significant immune cell activation and no compromise in immune cell viability. IgG-gFND remained at the tumor site following intratumoral injection compared to uFND which migrated to the liver and kidneys. CONCLUSION: antibody-conjugated FND may serve as immune drug delivery vehicles with "track and trace capabilities" to promote directed antitumor activity and minimize systemic toxicities.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Diamond and Carbon-based Materials Research · Nanoplatforms for cancer theranostics · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
The Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, United States
Department of Surgery, The Ohio State University, Columbus, Ohio 43210, United States
Columbus NanoWorks, Inc., 1507 Chambers Road, Columbus, Ohio 43212, United States
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, United States
Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio 43210, United States
Funding
National Cancer Institute · National Heart, Lung, and Blood Institute · National Institute of Allergy and Infectious Diseases · National Institutes of Health
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