journal article·2024-08-09

Review of the Applications of Micro/Nanorobots in Biomedicine

He Zhang, Jun Tang, Huiliang Cao, Chenguang Wang, Chong Shen, Jun Liu

ACS Applied Nano Materials· Volume 7· Issue 15
Publisher page

Abstract

The advancement of precision medicine in modern biomedicine has been significantly propelled by the emergence of micro/nanorobots. The combination of micro/nanorobots and biomedicine offers unique advantages and holds attractive potential for applications. It effectively addresses the challenges encountered by traditional robots in areas such as driving, sensing, intelligence and other aspects, especially in the application of cancer and cardiovascular diseases, which is a hot field of interdisciplinary research in recent years. This review succinctly delineates and analyzes the recent advancements of micro/nanorobots. First, the research achievements of micro/nanorobots in recent years are systematically classified and introduced from four perspectives: manufacturing design, drive control, biomedical application and degradation. In particular, in-depth discussions were conducted regarding the challenges and potential solutions encountered in each stage. Second, based on the latest research results of micro/nanorobots in biomedical applications, the development direction of industrial applications and key technical aspects that need to be paid attention to are emphasized. Finally, we discuss the challenges and the potential research opportunities of the micro/nanorobots. In the future, it is expected that micro/nanorobots will become more sophisticated and capable of performing multiple medical functions and tasks. They will be implemented in vivo to assist medical doctors in diagnosing and treating diseases. This advancement shows significant potential for the field of medicine.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Micro and Nano Robotics · Molecular Communication and Nanonetworks · Microfluidic and Bio-sensing Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Dynamic Measurement Technology and the School of Instrument and Electronics, North University of China, Taiyuan 030051, People’s Republic of China

Funding

Chinese Aeronautical Establishment · Shanxi Provincial Key Research and Development Project · National Natural Science Foundation of China · Excellent Youth Foundation of Shanxi Province · Fundamental research program of Shanxi Province · Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement

References (100+)

Show source-provided references
1. Feynman R. P. · Engineering and Science · 1960 · 23 · 22
2. Frutiger, D. R.; Kratochvil, B. E.; Vollmers, K.; Nelson, B. J. Magmites - wireless resonant magnetic microrobots. 2008 IEEE International Conference on Robotics and Automation, 2008.10.1109/ROBOT.2008.4543458 ↗
3. 10.1063/1.307965510.1063/1.3079655 ↗
4. 10.1103/PhysRevLett.49.5710.1103/PhysRevLett.49.57 ↗
5. 10.1038/344524a010.1038/344524a0 ↗
6. 10.1016/0141-6359(91)90088-Z10.1016/0141-6359(91)90088-Z ↗
7. 10.1021/ja047697z10.1021/ja047697z ↗
8. 10.1021/nl900186w10.1021/nl900186w ↗
9. 10.1021/nl402031t10.1021/nl402031t ↗
10. 10.1103/PhysRevLett.105.26830210.1103/PhysRevLett.105.268302 ↗
11. 10.1126/science.121413110.1126/science.1214131 ↗
12. 10.1021/am502458h10.1021/am502458h ↗
13. 10.1002/adma.20150432710.1002/adma.201504327 ↗
14. 10.1126/sciadv.aat438810.1126/sciadv.aat4388 ↗
15. 10.1038/s41551-023-01149-410.1038/s41551-023-01149-4 ↗
16. 10.1038/s41467-023-40300-210.1038/s41467-023-40300-2 ↗
17. 10.1007/s12045-011-0109-x10.1007/s12045-011-0109-x ↗
18. 10.1126/scirobotics.aam643110.1126/scirobotics.aam6431 ↗
19. 10.1002/admt.20220192810.1002/admt.202201928 ↗
20. 10.1002/adma.20200204710.1002/adma.202002047 ↗
21. 10.34133/cbsystems.010710.34133/cbsystems.0107 ↗
22. 10.1002/smll.20190690810.1002/smll.201906908 ↗
23. 10.1126/sciadv.aau965010.1126/sciadv.aau9650 ↗
24. 10.3390/pharmaceutics1207066510.3390/pharmaceutics12070665 ↗
25. 10.1002/adhm.20220239110.1002/adhm.202202391 ↗
26. 10.1002/smsc.20230021110.1002/smsc.202300211 ↗
27. 10.1002/aisy.20210011610.1002/aisy.202100116 ↗
28. 10.1002/aisy.20220020810.1002/aisy.202200208 ↗
29. 10.21037/qims.2018.06.0710.21037/qims.2018.06.07 ↗
30. 10.1002/adfm.20190574510.1002/adfm.201905745 ↗
31. 10.1016/j.cej.2020.12707310.1016/j.cej.2020.127073 ↗
32. 10.1016/j.colsurfa.2020.12586510.1016/j.colsurfa.2020.125865 ↗
33. 10.1016/j.apmt.2019.10050410.1016/j.apmt.2019.100504 ↗
34. 10.1021/acsnano.7b0834410.1021/acsnano.7b08344 ↗
35. 10.1119/1.1090310.1119/1.10903 ↗
36. 10.34133/cbsystems.010110.34133/cbsystems.0101 ↗
37. 10.1002/smll.20130285610.1002/smll.201302856 ↗
38. 10.1002/smll.20147003910.1002/smll.201470039 ↗
39. 10.1002/adma.20129002510.1002/adma.201290025 ↗
40. 10.1002/adfm.20180410710.1002/adfm.201804107 ↗
41. 10.34133/cbsystems.006010.34133/cbsystems.0060 ↗
42. 10.1021/acsnano.8b0923310.1021/acsnano.8b09233 ↗
43. 10.1177/027836491140723110.1177/0278364911407231 ↗
44. 10.1038/nnano.2013.9210.1038/nnano.2013.92 ↗
45. 10.1039/D2NH00018K10.1039/D2NH00018K ↗
46. 10.1016/j.colsurfa.2018.04.04910.1016/j.colsurfa.2018.04.049 ↗
47. 10.1126/sciadv.abg301510.1126/sciadv.abg3015 ↗
48. 10.1002/smll.20210398610.1002/smll.202103986 ↗
49. 10.1126/scirobotics.aaz951910.1126/scirobotics.aaz9519 ↗
50. 10.1038/srep0491910.1038/srep04919 ↗
51. 10.1007/s11431-018-9339-810.1007/s11431-018-9339-8 ↗
52. 10.1016/j.mehy.2017.02.01510.1016/j.mehy.2017.02.015 ↗
53. 10.1038/nprot.2016.03710.1038/nprot.2016.037 ↗
54. 10.1016/j.carbpol.2015.12.06410.1016/j.carbpol.2015.12.064 ↗
55. 10.1016/j.carbpol.2016.06.06310.1016/j.carbpol.2016.06.063 ↗
56. 10.1016/j.addr.2016.03.01210.1016/j.addr.2016.03.012 ↗
57. 10.3109/21691401.2016.114673110.3109/21691401.2016.1146731 ↗
58. 10.1080/01616412.2015.113302510.1080/01616412.2015.1133025 ↗
59. 10.3390/jfb701000610.3390/jfb7010006 ↗
60. 10.1002/adhm.20150072510.1002/adhm.201500725 ↗
61. 10.1016/j.progpolymsci.2011.06.00410.1016/j.progpolymsci.2011.06.004 ↗
62. 10.1016/j.eurpolymj.2015.11.01210.1016/j.eurpolymj.2015.11.012 ↗
63. 10.1021/acs.biomac.6b0050010.1021/acs.biomac.6b00500 ↗
64. 10.1016/j.biomaterials.2010.03.06410.1016/j.biomaterials.2010.03.064 ↗
65. 10.1002/smll.20210788810.1002/smll.202107888 ↗
66. 10.3390/polym1424550910.3390/polym14245509 ↗
67. Hu, C.; Riederer, K.; Klemmer, M.; Pane, S.; Nelson, B. J. (2016). Electrosynthesis of magnetoresponsive microrobot for targeted drug delivery using calcium alginate. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2016.10.1109/EMBC.2016.7591145 ↗
68. 10.1016/j.engreg.2020.08.00210.1016/j.engreg.2020.08.002 ↗
69. 10.1038/srep2871710.1038/srep28717 ↗
70. 10.1002/pat.614010.1002/pat.6140 ↗
71. 10.1021/nn304335x10.1021/nn304335x ↗
72. 10.1021/acs.chemrev.5b0004710.1021/acs.chemrev.5b00047 ↗
73. 10.1002/adfm.20170587210.1002/adfm.201705872 ↗
74. 10.1186/s11671-016-1320-110.1186/s11671-016-1320-1 ↗
75. 10.1002/adma.20080364510.1002/adma.200803645 ↗
76. 10.1007/s42235-021-0009-z10.1007/s42235-021-0009-z ↗
77. 10.1002/adfm.20200814910.1002/adfm.202008149 ↗
78. 10.1016/j.ccr.2011.01.02110.1016/j.ccr.2011.01.021 ↗
79. 10.1021/acs.accounts.8b0025410.1021/acs.accounts.8b00254 ↗
80. 10.1021/acs.accounts.8b0031510.1021/acs.accounts.8b00315 ↗
81. 10.1039/C7CS00516D10.1039/C7CS00516D ↗
82. 10.1021/acsnano.8b0290710.1021/acsnano.8b02907 ↗
83. 10.1021/acsnano.8b0599710.1021/acsnano.8b05997 ↗
84. 10.1038/s41565-023-01567-010.1038/s41565-023-01567-0 ↗
85. 10.1016/j.eurpolymj.2011.07.02510.1016/j.eurpolymj.2011.07.025 ↗
86. 10.34133/cbsystems.000910.34133/cbsystems.0009 ↗
87. 10.1016/j.tcm.2016.01.00310.1016/j.tcm.2016.01.003 ↗
88. 10.1007/s00170-012-4605-210.1007/s00170-012-4605-2 ↗
89. 10.1146/annurev-matsci-070115-03184110.1146/annurev-matsci-070115-031841 ↗
90. 10.1016/j.actbio.2016.01.03610.1016/j.actbio.2016.01.036 ↗
91. Bell, D. J.; Leutenegger, S.; Hammar, K. M.; Dong, L. X.; Nelson, B. J. (2007). Flagella-like Propulsion for Microrobots Using a Nanocoil and a Rotating Electromagnetic Field. Proceedings 2007 IEEE International Conference on Robotics and Automation, 2007.10.1109/ROBOT.2007.363136 ↗
92. 10.1126/sciadv.aba585510.1126/sciadv.aba5855 ↗
93. 10.1002/anie.20201626010.1002/anie.202016260 ↗
94. 10.1021/am502729y10.1021/am502729y ↗
95. 10.1002/advs.20200084310.1002/advs.202000843 ↗
96. 10.1002/smll.20217021210.1002/smll.202170212 ↗
97. 10.1039/C3LC50989C10.1039/C3LC50989C ↗
98. 10.1126/scirobotics.aaq049510.1126/scirobotics.aaq0495 ↗
99. 10.1038/nbt.407110.1038/nbt.4071 ↗
100. 10.1038/nature0458610.1038/nature04586 ↗