Recent Advances in Nanoparticle-Based Cancer Treatment: A Review
Source abstract
Abstract
The advent and subsequent development of nanotechnology in the past few years have been a boon to the healthcare industry and especially in cancer therapy. Cancer, as it is known, is one of the deadliest maladies that has been plaguing the entire world, and there are several available therapies for the treatment of cancer. In this review, we discuss some of the applications and development in nanoparticle (NP)-based therapies like gene therapy, chemotherapy, etc., and alongside the therapies, there is a detailed discussion about the five deadliest types of cancers. It has been found that NPs have been widely successful compared to the era when the drug was administered alone. However, there are some challenges associated as well. For example, one of the challenges is to make sure that the NP-based drug reaches the target site, and for that, several researchers have been working to design efficient drug-delivery systems, which are discussed in this review. In this review, our aim is to address the utility, developments, and drawbacks of NPs in cancer therapy.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · RNA Interference and Gene Delivery · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Petroleum Engineering, Rajiv Gandhi Institute of Petroleum Technology, Jais, Amethi 229304, India
Department of Chemical Engineering, Rajiv Gandhi Institute of Petroleum Technology, Jais, Amethi 229304, India
References (100+)
Show source-provided references
1. 10.1016/j.cell.2011.09.02410.1016/j.cell.2011.09.024 ↗
2. Cell Division, Cancer | Learn Science at Scitable, https://www.nature.com/scitable/topicpage/cell-division-and-cancer-14046590/ (accessed May 2, 2021).
3. 10.1007/s13277-014-2176-610.1007/s13277-014-2176-6 ↗
4. 10.1038/nbt.333010.1038/nbt.3330 ↗
5. 10.1186/s12951-018-0392-810.1186/s12951-018-0392-8 ↗
6. 10.1007/s11538-015-0110-810.1007/s11538-015-0110-8 ↗
7. Molnar C. · BCcampus · 2015
8. How Do Cancer Cells Grow and Spread? https://www.informedhealth.org/how-do-cancer-cells-grow-and-spread.html (accessed May 2, 2021).
9. 10.1002/ijc.2603110.1002/ijc.26031 ↗
10. Cell Division, Cancer | Learn Science at Scitable, https://www.nature.com/scitable/topicpage/cell-division-and-cancer-14046590/ (accessed Jul 7, 2020).
11. 10.1016/j.ijpharm.2011.05.04910.1016/j.ijpharm.2011.05.049 ↗
12. Drug Release—an overview | ScienceDirect Topics, https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/drug-release (accessed May 3, 2021).
13. 10.1021/acs.chemrev.5b0034610.1021/acs.chemrev.5b00346 ↗
14. 10.1517/1742524100360225910.1517/17425241003602259 ↗
15. Main Mechanisms to Control the Drug Release; Bruschi, M. L. B. T.S. Woodhead Publishing, 2015; Chapter 4, pp 37–62.10.1016/B978-0-08-100092-2.00004-7 ↗
16. 10.1039/C9RA04358F10.1039/C9RA04358F ↗
17. 10.1016/S0022-2836(65)80093-610.1016/S0022-2836(65)80093-6 ↗
18. 10.1038/nrd163210.1038/nrd1632 ↗
19. 10.1016/S0009-9236(97)90162-410.1016/S0009-9236(97)90162-4 ↗
20. 10.1039/D0RA01032D10.1039/D0RA01032D ↗
21. 10.1038/sj.bjc.660247910.1038/sj.bjc.6602479 ↗
22. 10.1038/bjc.1996.58710.1038/bjc.1996.587 ↗
23. 10.1016/S0927-7765(99)00064-810.1016/S0927-7765(99)00064-8 ↗
24. 10.1093/jjco/hyn11610.1093/jjco/hyn116 ↗
25. 10.1038/bjc.2011.610.1038/bjc.2011.6 ↗
26. 10.1158/1078-0432.CCR-03-065510.1158/1078-0432.CCR-03-0655 ↗
27. 10.3402/nano.v3i0.1849610.3402/nano.v3i0.18496 ↗
28. 10.1016/j.biomaterials.2011.04.05310.1016/j.biomaterials.2011.04.053 ↗
29. 10.1038/nrd141310.1038/nrd1413 ↗
30. 10.2147/IJN.S4906910.2147/IJN.S49069 ↗
31. 10.3109/1061186X.2012.71213010.3109/1061186X.2012.712130 ↗
32. 10.1039/D0MA00639D10.1039/D0MA00639D ↗
33. 10.1038/emm.2016.4410.1038/emm.2016.44 ↗
34. 10.1021/ac901889s10.1021/ac901889s ↗
35. 10.1021/mp200042810.1021/mp2000428 ↗
36. 10.1021/nn900918w10.1021/nn900918w ↗
37. 10.1038/s41598-019-39107-310.1038/s41598-019-39107-3 ↗
38. 10.1021/bi100950310.1021/bi1009503 ↗
39. CDC | Facts About Sulfur Mustard, https://emergency.cdc.gov/agent/sulfurmustard/basics/facts.asp (accessed May 2, 2021).
40. 10.1016/j.biomaterials.2015.09.01810.1016/j.biomaterials.2015.09.018 ↗
41. 10.1038/s41420-021-00453-910.1038/s41420-021-00453-9 ↗
42. Testicular Cancer: Types of Treatment | Cancer. Net, https://www.cancer.net/cancer-types/testicular-cancer/types-treatment (accessed May 2, 2021).
43. 10.3390/molecules2304082610.3390/molecules23040826 ↗
44. 10.1039/C7TB01510K10.1039/C7TB01510K ↗
45. 10.1021/acsnano.5b0380410.1021/acsnano.5b03804 ↗
46. 10.1016/j.ejpb.2015.03.01810.1016/j.ejpb.2015.03.018 ↗
47. 10.1016/j.canlet.2014.03.01310.1016/j.canlet.2014.03.013 ↗
48. 10.1016/j.ccr.2019.02.02510.1016/j.ccr.2019.02.025 ↗
49. 10.1016/j.ejmech.2020.11222910.1016/j.ejmech.2020.112229 ↗
50. 10.1038/nrclinonc.2015.12010.1038/nrclinonc.2015.120 ↗
51. 10.7150/ijms.363510.7150/ijms.3635 ↗
52. Prasanna P. G. S. · Transl. Cancer Res. · 2012 · 1 · 35
53. 10.1186/s12645-016-0024-710.1186/s12645-016-0024-7 ↗
54. 10.1016/j.addr.2008.04.01310.1016/j.addr.2008.04.013 ↗
55. 10.1016/j.mattod.2013.11.00310.1016/j.mattod.2013.11.003 ↗
56. 10.1073/pnas.112050810910.1073/pnas.1120508109 ↗
57. 10.1259/bjr/5944883310.1259/bjr/59448833 ↗
58. 10.1038/s41598-019-53706-010.1038/s41598-019-53706-0 ↗
59. 10.1021/acs.nanolett.6b0253610.1021/acs.nanolett.6b02536 ↗
60. 10.1016/j.addr.2016.01.00810.1016/j.addr.2016.01.008 ↗
61. 10.1038/mt.2015.11410.1038/mt.2015.114 ↗
62. 10.1002/adma.20160309510.1002/adma.201603095 ↗
63. 10.1038/srep2652610.1038/srep26526 ↗
64. 10.1007/s11242-013-0161-y10.1007/s11242-013-0161-y ↗
65. 10.1007/s13311-012-0144-710.1007/s13311-012-0144-7 ↗
66. 10.1016/j.radonc.2012.07.01110.1016/j.radonc.2012.07.011 ↗
67. 10.1248/yakushi.127.154910.1248/yakushi.127.1549 ↗
68. 10.1021/acsnano.6b0719510.1021/acsnano.6b07195 ↗
69. 10.1021/nn700063w10.1021/nn700063w ↗
70. 10.1002/adma.20070196910.1002/adma.200701969 ↗
71. 10.1021/nn901213a10.1021/nn901213a ↗
72. 10.1038/nmat376510.1038/nmat3765 ↗
73. 10.1016/j.addr.2010.03.00810.1016/j.addr.2010.03.008 ↗
74. 10.1038/7017110.1038/70171 ↗
75. 10.1021/bc060353910.1021/bc0603539 ↗
76. 10.1021/mp900015y10.1021/mp900015y ↗
77. 10.3109/1061186X.2012.71923210.3109/1061186X.2012.719232 ↗
78. 10.1146/annurev-bioeng-071910-12470910.1146/annurev-bioeng-071910-124709 ↗
79. 10.1038/mtna.2012.2810.1038/mtna.2012.28 ↗
80. 10.1021/ja301621z10.1021/ja301621z ↗
81. Lei P. · RNA Nanotechnol. Ther. · 2013 · 6 · 439
82. 10.3390/pharmaceutics1207064910.3390/pharmaceutics12070649 ↗
83. Gene Therapy, https://www.ndsu.edu/pubweb/~mcclean/plsc431/students/brandi.htmhttps://www.ndsu.edu/pubweb/~mcclean/plsc431/students/brandi.htm (accessed May 2, 2021).
84. 10.4018/978-1-4666-6363-310.4018/978-1-4666-6363-3 ↗
85. 10.1016/j.addr.2009.11.00610.1016/j.addr.2009.11.006 ↗
86. 10.1021/nl050055510.1021/nl0500555 ↗
87. 10.1016/j.addr.2009.03.00710.1016/j.addr.2009.03.007 ↗
88. 10.1002/adma.20070195210.1002/adma.200701952 ↗
89. 10.1002/jemt.2099210.1002/jemt.20992 ↗
90. 10.1038/sj.gt.330282810.1038/sj.gt.3302828 ↗
91. Di Marco M. · Int. J. Nanomedicine · 2007 · 2 · 609
92. 10.1016/j.ymthe.2003.11.00410.1016/j.ymthe.2003.11.004 ↗
93. 10.1038/sj.gt.330126910.1038/sj.gt.3301269 ↗
94. 10.1021/ja038085210.1021/ja0380852 ↗
95. 10.1021/la062092x10.1021/la062092x ↗
96. 10.1016/j.colsurfa.2007.09.01710.1016/j.colsurfa.2007.09.017 ↗
97. 10.1039/b902358e10.1039/b902358e ↗
98. 10.1039/c0jm04381h10.1039/c0jm04381h ↗
99. 10.1021/ja111448t10.1021/ja111448t ↗
100. 10.1016/j.actbio.2012.12.03210.1016/j.actbio.2012.12.032 ↗