Multidimensional additive manufacturing micro/nanorobots: from elaborate design to smart cargo delivery
Source abstract
Abstract
Micro/nanorobots have attracted much attention because of their potential to perform complex tasks with high precision under controlled actuation within the human body, such as targeted cargo delivery, lesion exploration, and minimally invasive surgery. Among the various emerging fabrication technologies, multidimensional additive manufacturing (MAM) technology can enable the design and fabrication of complex structures with multifunctional characteristics. Compared with traditional manufacturing methods, MAM significantly reduces production complexity and time while enhancing design flexibility and customization. This review provides a comprehensive overview of MAM technologies for constructing micro/nanorobots, along with their applications and associated challenges in the biomedical field. In addition, emerging MAM approaches, including 4D, 5D, and 6D printing assisted by physical intelligence, machine learning, and artificial intelligence show great potential for designing and fabricating more sophisticated and intelligent micro/nanorobots, thereby advancing their clinical translation in the near future.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Micro and Nano Robotics · Soft Robotics and Applications · Advanced Materials and Mechanics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Experimental Education/Administration Center, National Demonstration Center for Experimental Education of Basic Medical Sciences, Key Laboratory of Functional Proteomics of Guangdong Province, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
Cardiometabolic Medicine Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Nanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China
School of Nursing, Southern Medical University, Guangzhou 510515, China
Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
School of Biomedical Engineering, Guangdong Provincial Key Laboratory of Medical Image Processing, Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
Funding
Guangdong Medical Research Foundation · Basic and Applied Basic Research Foundation of Guangdong Province · National Natural Science Foundation of China · National Key Research and Development Program of China
References (100+)
Show source-provided references
1. Krumhansl · Phys. Today · 1979 · 32 · 2510.1063/1.2995274 ↗
2. K. E.Drexler , Engines of Creation: The Coming Era of Nanotechnology , Anchor Press/Doubleday , New York, NY , 1986
3. Magdanz · Adv. Mater. · 2013 · 25 · 658110.1002/adma.201302544 ↗
4. Goddard · Nat. Ecol. Evol. · 2021 · 5 · 21910.1038/s41559-020-01358-z ↗
5. Guenat · Nat. Commun. · 2022 · 13 · 335910.1038/s41467-022-31150-5 ↗
6. Chen · Small · 2024 · 20 · 230460710.1002/smll.202304607 ↗
7. Bogue · Ind. Robot · 2015 · 42 · 9810.1108/IR-11-2014-0409 ↗
8. Soto · Adv. Sci. · 2020 · 7 · 200220310.1002/advs.202002203 ↗
9. Su · Adv. Healthcare Mater. · 2023 · 12 · 220239110.1002/adhm.202202391 ↗
10. Park · Adv. Healthcare Mater. · 2019 · 8 · e190021310.1002/adhm.201900213 ↗
11. Chatzipirpiridis · IEEE Trans. Magn. · 2014 · 50 · 110.1109/TMAG.2014.2325671 ↗
12. Yin · RSC Adv. · 2020 · 10 · 777110.1039/C9RA09917D ↗
13. Gao · J. Am. Chem. Soc. · 2012 · 134 · 89710.1021/ja210874s ↗
14. Goel · Biomed. Mater. · 2025 · 4 · 19
15. Power · Small · 2018 · 14 · 170396410.1002/smll.201703964 ↗
16. Meloni · Sci. Rep. · 2020 · 10 · 1548010.1038/s41598-020-72493-7 ↗
17. Li · Small · 2016 · 12 · 609810.1002/smll.201601846 ↗
18. Liu · Small · 2018 · 14 · e170454610.1002/smll.201704546 ↗
19. Chang · Nanoscale · 2022 · 14 · 21910.1039/D1NR07172F ↗
20. Joyee · Soft Rob. · 2019 · 6 · 33310.1089/soro.2018.0082 ↗
21. Yang · J. Mater. Chem. C · 2025 · 13 · 1513510.1039/D5TC00958H ↗
22. Xiong · Light: Sci. Appl. · 2024 · 13 · 5510.1038/s41377-024-01405-5 ↗
23. Wang · Adv. Intell. Syst. · 2024 · 6 · 230009310.1002/aisy.202300093 ↗
24. Teo · Chem. Commun. · 2016 · 52 · 433310.1039/C6CC00115G ↗
25. Wang · ACS Appl. Mater. Interfaces · 2017 · 9 · 2397410.1021/acsami.7b06402 ↗
26. Yasa · Adv. Mater. · 2018 · 30 · e180413010.1002/adma.201804130 ↗
27. Raman · Proc. Natl. Acad. Sci. U. S. A. · 2016 · 113 · 349710.1073/pnas.1516139113 ↗
28. Ceylan · ACS Nano · 2019 · 13 · 335310.1021/acsnano.8b09233 ↗
29. Gao · J. Am. Chem. Soc. · 2010 · 132 · 1440310.1021/ja1072349 ↗
30. Ahmed · Nano Lett. · 2016 · 16 · 496810.1021/acs.nanolett.6b01601 ↗
31. Feng · Lab Chip · 2016 · 16 · 231710.1039/C6LC00431H ↗
32. Zeng · Adv. Mater. · 2015 · 27 · 388310.1002/adma.201501446 ↗
33. Zeng · Macromol. Rapid Commun. · 2018 · 39 · 170022410.1002/marc.201700224 ↗
34. Bayati · J. Chem. Phys. · 2019 · 150 · 23490210.1063/1.5101023 ↗
35. Si · ACS Nano · 2020 · 14 · 1534910.1021/acsnano.0c05779 ↗
36. Kutorglo · ACS Appl. Mater. Interfaces · 2021 · 13 · 1617310.1021/acsami.0c20055 ↗
37. de Avila · Nat. Commun. · 2017 · 8 · 27210.1038/s41467-017-00309-w ↗
38. Felfoul · Nat. Nanotechnol. · 2016 · 11 · 94110.1038/nnano.2016.137 ↗
39. Li · Sci. Rob. · 2018 · 3 · eaat882910.1126/scirobotics.aat8829 ↗
40. Jeon · Sci. Rob. · 2019 · 4 · eaav431710.1126/scirobotics.aav4317 ↗
41. Ma · Nano Lett. · 2019 · 19 · 450510.1021/acs.nanolett.9b01320 ↗
42. Sun · Adv. Mater. · 2023 · 35 · 220779110.1002/adma.202207791 ↗
43. Su · Sci. Adv. · 2023 · 9 · eadj088310.1126/sciadv.adj0883 ↗
44. Wang · J. Drug Delivery Sci. Technol. · 2018 · 46 · 4610.1016/j.jddst.2018.04.019 ↗
45. Li · Small · 2023 · 19 · 230188910.1002/smll.202301889 ↗
46. de Avila · Acc. Chem. Res. · 2018 · 51 · 190110.1021/acs.accounts.8b00202 ↗
47. Zhou · Biomater. Sci. · 2023 · 11 · 751210.1039/D3BM01095C ↗
48. Halder · Biosens. Bioelectron. · 2019 · 139 · 11133410.1016/j.bios.2019.111334 ↗
49. Moshayedi · EAI Endorsed Trans. AI Robot · 2024 · 3 · 1
50. Sharma · Int. J. Adv. Sci. Res. · 2025 · 13 · 495
51. Jia · Nat. Mater. · 2022 · 21 · 70310.1038/s41563-022-01258-6 ↗
52. Keneth · Adv. Mater. · 2021 · 33 · 200338710.1002/adma.202003387 ↗
53. Zhan · Int. J. Mol. Sci. · 2022 · 23 · 379010.3390/ijms23073790 ↗
54. Wang · JACC Cardiovasc. Imaging · 2021 · 14 · 4110.1016/j.jcmg.2019.12.022 ↗
55. Singh · ACS Chem. Neurosci. · 2021 · 12 · 183510.1021/acschemneuro.1c00087 ↗
56. Dabbagh · Nat. Commun. · 2022 · 13 · 587510.1038/s41467-022-33409-3 ↗
57. Sharma · Curr. Drug Delivery · 2023 · 20 · 75210.2174/1567201820666221207140956 ↗
58. Zhang · Small · 2022 · 18 · 220051410.1002/smll.202200514 ↗
59. Zhou · Adv. Mater. · 2024 · 36 · 240932610.1002/adma.202409326 ↗
60. Alcantara · Small · 2019 · 15 · 180500610.1002/smll.201805006 ↗
61. Zub · Adv. Mater. · 2022 · 34 · 210501510.1002/adma.202105015 ↗
62. Kumar · J. Colloid Interface Sci. · 2022 · 623 · 9610.1016/j.jcis.2022.05.011 ↗
63. You · Small · 2024 · 20 · 240263810.1002/smll.202402638 ↗
64. Seoane-Viano · J. Controlled Release · 2021 · 332 · 36710.1016/j.jconrel.2021.02.027 ↗
65. Ligon · Chem. Rev. · 2017 · 117 · 1021210.1021/acs.chemrev.7b00074 ↗
66. Dabbagh · iScience · 2021 · 24 · 10201210.1016/j.isci.2020.102012 ↗
67. Buchner · Nature · 2023 · 623 · 52210.1038/s41586-023-06684-3 ↗
68. Bishop · Genes Dis. · 2017 · 4 · 18510.1016/j.gendis.2017.10.002 ↗
69. Panwar · Molecules · 2016 · 21 · 68510.3390/molecules21060685 ↗
70. Salentijn · Anal. Chem. · 2017 · 89 · 705310.1021/acs.analchem.7b00828 ↗
71. Krueger · J. Controlled Release · 2022 · 351 · 44410.1016/j.jconrel.2022.09.032 ↗
72. Kafle · Polymers · 2021 · 13 · 310110.3390/polym13183101 ↗
73. Mahdavi · Ann. Biomed. Eng. · 2020 · 48 · 195510.1007/s10439-020-02537-6 ↗
74. Wu · Mater. Horiz. · 2024 · 12 · 40110.1039/D4MH01160K ↗
75. Quan · Bioact. Mater. · 2020 · 5 · 110
76. Serrano · Pharmaceutics · 2023 · 15 · 31310.3390/pharmaceutics15020313 ↗
77. Long · Curr. Pharm. Des. · 2017 · 23 · 43310.2174/1381612822666161026162707 ↗
78. Luo · J. Mech. Behav. Biomed. Mater. · 2023 · 148 · 10623110.1016/j.jmbbm.2023.106231 ↗
79. Hosseinabadi · Appl. Mater. Today · 2023 · 30 · 10172110.1016/j.apmt.2022.101721 ↗
80. Zhang · Research · 2025 · 8 · 073410.34133/research.0734 ↗
81. Guo · Carbohydr. Polym. · 2023 · 315 · 12100610.1016/j.carbpol.2023.121006 ↗
82. Awad · Int. J. Pharm. · 2020 · 586 · 11959410.1016/j.ijpharm.2020.119594 ↗
83. Chen · Small · 2025 · 21 · 241257410.1002/smll.202412574 ↗
84. Hu · Nat. Commun. · 2024 · 15 · 739910.1038/s41467-024-51518-z ↗
85. Wang · ACS Nano · 2022 · 16 · 1489510.1021/acsnano.2c05783 ↗
86. He · Nano Lett. · 2023 · 23 · 494710.1021/acs.nanolett.3c00759 ↗
87. Gao · RSC Adv. · 2024 · 14 · 1427810.1039/D4RA00495G ↗
88. Rodrigo · Sci. Rep. · 2016 · 6 · 3372910.1038/srep33729 ↗
89. Kochergin · ACS Nano · 2021 · 15 · 1845810.1021/acsnano.1c08136 ↗
90. Mohanty · Proc. R. Soc. A · 2020 · 476 · 2020062110.1098/rspa.2020.0621 ↗
91. Yu · Ultrason. Sonochem. · 2024 · 102 · 10671410.1016/j.ultsonch.2023.106714 ↗
92. Hong · Sci. Adv. · 2024 · 10 · eadn758210.1126/sciadv.adn7582 ↗
93. Law · ACS Nano · 2023 · 17 · 1297110.1021/acsnano.2c11733 ↗
94. Wang · J. Am. Chem. Soc. · 2023 · 145 · 2718510.1021/jacs.3c09223 ↗
95. Xu · ACS Nano · 2018 · 12 · 32710.1021/acsnano.7b06398 ↗
96. Pellicciotta · Adv. Funct. Mater. · 2023 · 33 · 221480110.1002/adfm.202214801 ↗
97. Bozuyuk · ACS Nano · 2018 · 12 · 961710.1021/acsnano.8b05997 ↗
98. Chen · Smart Mater. Struct. · 2023 · 32 · 08501410.1088/1361-665X/ace1ba ↗
99. Bachmann · Adv. Intell. Syst. · 2020 · 2 · 200007810.1002/aisy.202000078 ↗
100. Supik · IEEE Rob. Autom. Lett. · 2023 · 8 · 809810.1109/LRA.2023.3324881 ↗