Nanoparticles as a Hedgehog signaling inhibitor for the suppression of cancer growth and metastasis
Source abstract
Abstract
Nanoparticles (NPs) have been intensively explored for the treatment of tumors during the past decade, yet little information has been provided on the NPs' inherent therapeutic activity against cancers. With this goal in mind, we reveal that biocompatible silicon (Si) NPs (SiNPs) feature excellent anti-growth and anti-metastasis activities against prostate cancer cells that show aberrant activation of the Hedgehog (HH) signaling pathway. Without activation by the Sonic hedgehog (Shh)-agonist, mouse embryonic fibroblast (NIH3T3) cells show no response to SiNP exposure. The distinct inhibitory effect of SiNPs on the HH signaling pathway leads to significant suppression of the proliferation, migration, and invasion of human prostate cancer cells. Crucially, in two mouse tumor models, the growth and metastasis of prostate cancer cells are also efficiently inhibited by SiNPs.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Hedgehog Signaling Pathway Studies · Ocular Disorders and Treatments · Oral and Maxillofacial Pathology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratory of Nanoscale Biochemical Analysis
Institute of Functional Nano and Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology
Soochow University
Suzhou 215123
China
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation
Medical Research Center
Sun Yat-Sen Memorial Hospital
Sun Yat-Sen University
Guangzhou 510120
Funding
National Natural Science Foundation of China · Natural Science Foundation of Jiangsu Province · Priority Academic Program Development of Jiangsu Higher Education Institutions · Ministry of Education of the People's Republic of China · Collaborative Innovation Center of Suzhou Nano Science and Technology
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