journal article·2019Open access

Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells

Aijun Li, Yu Fan, Xueyan Cao, Liang Chen, Le Wang, Carla S. Alves, Serge Mignani, Jean-Pierre Majoral, Helena Tomás, Xiangyang Shi

Nanoscale· Volume 11· Issue 37

Abstract

A novel bioactive macromolecule based on morpholino-functionalized phosphorus dendrimers (generation 2, G2-Mor+) was developed for osteogenic differentiation of mesenchymal stem cells (MSCs). Interestingly, through in vitro tests, it was shown that G2-Mor+ dendrimer can strongly promote the transformation of MSCs into osteoblasts, which implies the potential application of phosphorus dendrimers in bone regeneration for precision regenerative medicine.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Dendrimers and Hyperbranched Polymers · Bone health and treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials

International Joint Laboratory for Advanced Fiber and Low-dimension Materials

College of Chemistry

Chemical Engineering and Biotechnology

Donghua University

College of Chemistry and Chemical Engineering

Shanghai University of Engineering Science

Shanghai 201620

People's Republic of China

CQM-Centro de Quimica da Madeira

Universidade da Madeira

Campus da Penteada

9020-105 Funchal

Portugal

Laboratoire de Chimie de Coordination du CNRS

F-31077 Toulouse Cedex 4

France

Funding

Shanghai Municipal Education Commission · Science and Technology Commission of Shanghai Municipality · Fundação para a Ciência e a Tecnologia · National Natural Science Foundation of China

References (32)

Show source-provided references
1. Dieppe · Lancet · 2005 · 365 · 96510.1016/S0140-6736(05)71086-2 ↗
2. Humbert · Front. Immunol. · 2019 · 10 · 1510.3389/fimmu.2019.00663 ↗
3. Mohammadi · J. Controlled Release · 2018 · 274 · 3510.1016/j.jconrel.2018.01.032 ↗
4. Roseti · Mater. Sci. Eng., C · 2017 · 78 · 124610.1016/j.msec.2017.05.017 ↗
5. Wang · Bioact. Mater. · 2017 · 2 · 22410.1016/j.bioactmat.2017.05.007 ↗
6. Roberts · Organogenesis · 2012 · 8 · 11410.4161/org.23306 ↗
7. Bose · Trends Biotechnol. · 2012 · 30 · 54610.1016/j.tibtech.2012.07.005 ↗
8. Amini · CRC Crit. Rev. Bioeng. · 2012 · 40 · 363
9. Luo · ACS Appl. Mater. Interfaces · 2015 · 7 · 633110.1021/acsami.5b00862 ↗
10. Shah · Adv. Mater. · 2014 · 26 · 367310.1002/adma.201400523 ↗
11. Chen · Cell Death Differ. · 2016 · 23 · 112810.1038/cdd.2015.168 ↗
12. Salgado · Macromol. Biosci. · 2004 · 4 · 74310.1002/mabi.200400026 ↗
13. Spiro · J. Trauma: Inj., Infect., Crit. Care · 2010 · 69 · 147310.1097/TA.0b013e3181dc59e4 ↗
14. Yuasa · PLoS One · 2015 · 10 · e011646210.1371/journal.pone.0116462 ↗
15. Oh · Proc. Natl. Acad. Sci. U. S. A. · 2009 · 106 · 213010.1073/pnas.0813200106 ↗
16. Zong · J. Bone Miner. Metab. · 2016 · 34 · 15110.1007/s00774-015-0659-1 ↗
17. Lee · Maxillofac. Plast. Reconstr. Surg. · 2017 · 39 · 710.1186/s40902-017-0104-6 ↗
18. Yi · ACS Nano · 2010 · 4 · 643910.1021/nn101373r ↗
19. Lee · Nanoscale · 2015 · 7 · 1164210.1039/C5NR01580D ↗
20. Samberg · Nanomedicine · 2012 · 7 · 119710.2217/nnm.12.18 ↗
21. Shen · Nanoscale · 2010 · 2 · 159610.1039/c0nr00072h ↗
22. Qiao · Prog. Polym. Sci. · 2015 · 44 · 110.1016/j.progpolymsci.2014.08.002 ↗
23. Fan · Small Methods · 2017 · 1 · 170022410.1002/smtd.201700224 ↗
24. Xiong · Sci. China Mater. · 2018 · 61 · 138710.1007/s40843-018-9271-4 ↗
25. Caminade · Chem. Commun. · 2017 · 53 · 983010.1039/C7CC04949H ↗
26. Goncalves · Curr. Med. Chem. · 2012 · 19 · 496910.2174/0929867311209024969 ↗
27. Launay · J. Organomet. Chem. · 1997 · 529 · 5110.1016/S0022-328X(96)06293-6 ↗
28. Loup · Chem. – Eur. J. · 1999 · 5 · 364410.1002/(SICI)1521-3765(19991203)5:12<3644::AID-CHEM3644>3.0.CO;2-I ↗
29. Padié · New J. Chem. · 2009 · 33 · 31810.1039/B815259D ↗
30. Ihnatsyeu-Kachan · Colloids Interfaces · 2017 · 1 · 610.3390/colloids1010006 ↗
31. Apartsin · New J. Chem. · 2018 · 42 · 898510.1039/C8NJ01229F ↗
32. Liu · J. Mater. Chem. B · 2016 · 4 · 438910.1039/C5TB01898F ↗