journal article·2026

Enhancing tumor ROS generation via nanozyme-amplified photodynamic therapy with oxygen-supplying bacterial OMVs

Haibing Dai, Yongqi Wang, Xiang Chen, Jiale Zhu, Han Wang, Daizong Cui, Huibin Wu, Guan Huang, Ran Luo, Jianbo Yu, Weiqun Li, Min Zhao, Lin Mei

Nanoscale· Volume 18· Issue 7
Publisher page

Abstract

In this study, OMV@Hb-Ce6-Mn was constructed by co-loading hemoglobin (Hb) and chlorin e6 (Ce6) onto OMVs, followed by modification with manganese dioxide (MnO2) nanoparticles. OMV@Hb-Ce6-Mn significantly suppressed tumor growth and elicited potent systemic antitumor immunity, achieving a 50-day survival rate of 83.3%.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer Research and Treatments · Bacterial Infections and Vaccines

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Life Science, Northeast Forestry University, Harbin 150040, China

Longgang Central Hospital of Shenzhen, Shenzhen, 518116, China

Shenzhen Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518116, China

State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China

Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China

Funding

Shenzhen Science and Technology Innovation Commission · Basic and Applied Basic Research Foundation of Guangdong Province

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