Secondary electron dynamics in core–shell–satellite nanoparticles: a computational strategy for targeted cancer treatment
Source abstract
Abstract
-Au nanoparticles as effective radiosensitizers. By investigating the interaction of individual nanoparticles situated within a water phantom of 20 micrometers in diameter with monochromatic photon beams at energies of 50, 100, and 150 keV, we analyse how variations in the structural composition of Au nanoparticles and their concentrations within these multifaceted nanoparticles influence the efficacy of radiation therapy, employing Monte Carlo simulations corroborated by the general-purpose radiation transport code PHITS. Our investigation aspires to refine nanoparticle-based methodologies to enhance cancer treatment outcomes, potentially facilitating the development of more targeted therapeutic interventions that minimize adverse effects while improving patient survival rates.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Radiation Therapy and Dosimetry · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratory of Thin Film Technologies, ITAM, Far Eastern Federal University, Vladivostok 690922, Russia
Institute of Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690022, Russia
Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna 141980, Russia
Dubna State University, Dubna 141982, Russia
Department of Materials Science and Engineering, Korea University, Seoul 02841, Republic of Korea
Sakhalin State University, Yuzhno-Sakhalinsk 693000, Russia
Funding
Ministry of Science and Higher Education of the Russian Federation · National Research Foundation of Korea
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