Vanadium incorporation in ferrite nanoparticles serves as an electron buffer and anisotropy tuner in catalytic and hyperthermia applications
Source abstract
Abstract
Cancer research has gradually shifted its focus from individual therapies to a combination of them for enhanced treatment effectiveness. In particular, the increased interest in the field of catalytic medicine through nanozymes proposes promising combinations with photothermal therapy, photodynamic therapy, and magnetic fluid hyperthermia (MFH). Nanozyme activity centers around the hydroxyl radical ˙OH, the most toxic of the reactive oxygen species (ROS). With a synergistic approach in mind, we studied VxFe3-xO4 magnetic nanoparticles (MNPs) as agents for ROS production and heating. These MNPs were exhaustively characterised both morphologically and magnetically. A compositional analysis through electron microscopy and spectroscopy unveils a core-shell structure with a V-rich shell. A study of the power absorption of these MNPs fixed into a gel matrix, emulating cytosol viscosity, provides values of up to 1000 W g-1 for samples with 0.5 wt% MNPs, an AC magnetic field amplitude of 65 mT and a frequency of 350 kHz, typical in the MFH application. A concentration of the ˙OH-adduct of up to 2300 nM has been measured through electron spin resonance analysis as a result of peroxidase-like activity. Through the comparison with similarly-sized ferrite MNPs, we determined that V incorporation lowers the magnetic anisotropy and serves as an electron buffer, explaining the enhanced MFH and ROS-production results.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Vanadium and Halogenation Chemistry · Advanced Nanomaterials in Catalysis · Catalysis and Oxidation Reactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC – Universidad de Zaragoza, 50018, Zaragoza, Spain
Departamento de Física de la Materia Condensada, Facultad de Ciencias Universidad de Zaragoza, 50018, Zaragoza, Spain
Laboratorio de Microscopías Avanzadas (LMA), Universidad de Zaragoza, Calle Mariano Esquillor, 50018, Zaragoza, Spain
Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Road, Piscataway, 08854, NJ, USA
Instituto de Nanociencia y Nanotecnología, CNEA-CONICET, Av. E. Bustillo 9500, 8400, S.C. Bariloche, RN, Argentina
Instituto Balseiro, UNCUYO, Av. E. Bustillo 9500, 8400, S.C. Bariloche, RN, Argentina
Departamento de Física, Universidad del País Vasco (UPV/EHU), Leioa 48940, Spain
SGIker, Universidad del País Vasco – UPV/EHU, 48940 Leioa, Spain
Departamento de Electricidad y Electrónica, Universidad del País Vasco (UPV/EHU), Leioa 48940, Spain
ARAID Foundation, 50018, Zaragoza, Spain
Funding
Consejo Nacional de Investigaciones Científicas y Técnicas · Agencia Estatal de Investigación · H2020 Marie Skłodowska-Curie Actions · Universidad de Zaragoza · HORIZON EUROPE Marie Sklodowska-Curie Actions
References (79)
Show source-provided references
1. Gao · Nat. Nanotechnol. · 2007 · 2 · 57710.1038/nnano.2007.260 ↗
2. Bokare · J. Hazard. Mater. · 2014 · 275 · 12110.1016/j.jhazmat.2014.04.054 ↗
3. Dai · Biomaterials · 2019 · 219 · 11937410.1016/j.biomaterials.2019.119374 ↗
4. Dong · Adv. Funct. Mater. · 2019 · 30 · 190707110.1002/adfm.201907071 ↗
5. Dai · Bioengineering · 2022 · 9 · 47410.3390/bioengineering9090474 ↗
6. Nanozymology: Connecting Biology and Nanotechnology , ed. X. Yan , Springer Singapore , 2020
7. Pozzi · J. Chem. Educ. · 2024 · 101 · 314610.1021/acs.jchemed.4c00089 ↗
8. Fu · J. Food Drug Anal. · 2014 · 22 · 6410.1016/j.jfda.2014.01.005 ↗
9. Carrey · J. Appl. Phys. · 2011 · 109 · 08392110.1063/1.3551582 ↗
10. Néel · Ann. Géophys. · 1949 · 5 · 99
11. Coffey · Phys. Rev. B: Condens. Matter Mater. Phys. · 1995 · 52 · 1595110.1103/PhysRevB.52.15951 ↗
12. Bødker · Phys. Rev. Lett. · 1994 · 72 · 28210.1103/PhysRevLett.72.282 ↗
13. Yanes · Phys. Rev. B: Condens. Matter Mater. Phys. · 2007 · 76 · 06441610.1103/PhysRevB.76.064416 ↗
14. Gandia · Nanoscale · 2020 · 12 · 1608110.1039/D0NR02189J ↗
15. Bobo · Pharm. Res. · 2016 · 33 · 237310.1007/s11095-016-1958-5 ↗
16. Clerc · J. Controlled Release · 2018 · 270 · 12010.1016/j.jconrel.2017.11.050 ↗
17. Bae · Appl. Phys. Lett. · 2006 · 89 · 25250310.1063/1.2420769 ↗
18. Menelaou · Dalton Trans. · 2014 · 43 · 362610.1039/c3dt52860j ↗
19. Yin · Small · 2014 · 10 · 410610.1002/smll.201400963 ↗
20. Apostolov · Eur. Phys. J. B · 2019 · 92 · 5810.1140/epjb/e2019-90567-2 ↗
21. Castellanos-Rubio · Chem. Mater. · 2021 · 33 · 313910.1021/acs.chemmater.0c04794 ↗
22. Mazarío · J. Phys. Chem. C · 2015 · 119 · 682810.1021/jp510937r ↗
23. Sanz · ACS Appl. Nano Mater. · 2020 · 3 · 871910.1021/acsanm.0c01545 ↗
24. Serantes · J. Phys. Chem. C · 2014 · 118 · 592710.1021/jp410717m ↗
25. Valdés · Phys. Rev. Appl. · 2021 · 15 · 04400510.1103/PhysRevApplied.15.044005 ↗
26. Zhao · J. Inorg. Biochem. · 2010 · 104 · 37110.1016/j.jinorgbio.2009.11.007 ↗
27. Treviño · Biol. Trace Elem. Res. · 2018 · 188 · 6810.1007/s12011-018-1540-6 ↗
28. Zhang · J. Inorg. Biochem. · 2006 · 100 · 8010.1016/j.jinorgbio.2005.10.006 ↗
29. Yang · Pharm. Res. · 2004 · 21 · 102610.1023/B:PHAM.0000029293.89113.d5 ↗
30. Capella · Cell Biol. Toxicol. · 2007 · 23 · 41310.1007/s10565-007-9003-4 ↗
31. Willsky · Physiol. Genomics · 2006 · 26 · 19210.1152/physiolgenomics.00196.2005 ↗
32. Huang · J. Biol. Chem. · 2001 · 276 · 2239710.1074/jbc.M010828200 ↗
33. Hu · Biomed. Mater. · 2020 · 16 · 01410110.1088/1748-605X/abb523 ↗
34. Sanz-Sagué · Chem.-Biol. Interact. · 2024 · 394 · 11097710.1016/j.cbi.2024.110977 ↗
35. Fortin · Eur. Biophys. J. · 2007 · 37 · 22310.1007/s00249-007-0197-4 ↗
36. Noh · Nano Lett. · 2012 · 12 · 371610.1021/nl301499u ↗
37. Kosmulski · J. Colloid Interface Sci. · 2004 · 275 · 21410.1016/j.jcis.2004.02.029 ↗
38. Kosmulski · Adv. Colloid Interface Sci. · 2018 · 251 · 11510.1016/j.cis.2017.10.005 ↗
39. Kovalenko · J. Am. Chem. Soc. · 2007 · 129 · 635210.1021/ja0692478 ↗
40. Kim · J. Am. Chem. Soc. · 2008 · 131 · 45410.1021/ja8086906 ↗
41. Moya · Phys. Chem. Chem. Phys. · 2015 · 17 · 2737310.1039/C5CP03395K ↗
42. Roca · Adv. Drug Delivery Rev. · 2019 · 138 · 6810.1016/j.addr.2018.12.008 ↗
43. B. D.Cullity and C. D.Graham , Introduction to Magnetic Materials , Wiley , 200810.1002/9780470386323 ↗
44. Lopez Maldonado · J. Nanopart. Res. · 2014 · 16 · 248210.1007/s11051-014-2482-3 ↗
45. Datt · Nanoscale · 2016 · 8 · 520010.1039/C5NR06791J ↗
46. Song · Phys. Chem. Chem. Phys. · 2015 · 17 · 1882510.1039/C5CP01301A ↗
47. De Biasi · J. Magn. Magn. Mater. · 2013 · 326 · 13810.1016/j.jmmm.2012.08.046 ↗
48. Raikher · Phys. Rev. B: Condens. Matter Mater. Phys. · 1994 · 50 · 625010.1103/PhysRevB.50.6250 ↗
49. de Biasi · J. Magn. Magn. Mater. · 2003 · 262 · 23510.1016/S0304-8853(02)01496-8 ↗
50. Faílde · Nanoscale · 2024 · 16 · 1431910.1039/D4NR02045F ↗
51. Fujii · Phys. Rev. B: Condens. Matter Mater. Phys. · 1999 · 59 · 319510.1103/PhysRevB.59.3195 ↗
52. Yamashita · Appl. Surf. Sci. · 2008 · 254 · 244110.1016/j.apsusc.2007.09.063 ↗
53. Biesinger · Appl. Surf. Sci. · 2011 · 257 · 271710.1016/j.apsusc.2010.10.051 ↗
54. Biesinger · Appl. Surf. Sci. · 2010 · 257 · 88710.1016/j.apsusc.2010.07.086 ↗
55. Chen · Phys. Rev. B: Condens. Matter Mater. Phys. · 2009 · 79 · 10410310.1103/PhysRevB.79.104103 ↗
56. Su · Catal. Lett. · 2002 · 83 · 11510.1023/A:1021042232178 ↗
57. Gloter · Eur. Phys. J. B · 2001 · 22 · 17910.1007/PL00011142 ↗
58. Tan · Ultramicroscopy · 2012 · 116 · 2410.1016/j.ultramic.2012.03.002 ↗
59. Kuimova · Nat. Chem. · 2009 · 1 · 6910.1038/nchem.120 ↗
60. Valdés · Phys. Rev. Appl. · 2023 · 19 · 01404210.1103/PhysRevApplied.19.014042 ↗
61. Myrovali · Sci. Rep. · 2016 · 6 · 3793410.1038/srep37934 ↗
62. Branquinho · Sci. Rep. · 2013 · 3 · 288710.1038/srep02887 ↗
63. Valdés · Phys. Rev. Appl. · 2020 · 14 · 01402310.1103/PhysRevApplied.14.014023 ↗
64. Nemati · J. Phys. Chem. C · 2018 · 122 · 236710.1021/acs.jpcc.7b10528 ↗
65. Rodrigo · Int. J. Hyperthermia · 2020 · 37 · 97610.1080/02656736.2020.1802071 ↗
66. Atkinson · IEEE Trans. Biomed. Eng. · 1984 · BME-31 · 7010.1109/TBME.1984.325372 ↗
67. Herrero de la Parte · Cancers · 2022 · 14 · 308410.3390/cancers14133084 ↗
68. Castellanos-Rubio · ACS Appl. Mater. Interfaces · 2020 · 12 · 2791710.1021/acsami.0c03222 ↗
69. Moreno Maldonado · J. Phys. Chem. C · 2019 · 123 · 2061710.1021/acs.jpcc.9b05371 ↗
70. Saito · Free Radical Res. · 2009 · 43 · 66810.1080/10715760902988850 ↗
71. Nuñez · Appl. Surf. Sci. · 2024 · 656 · 15965510.1016/j.apsusc.2024.159655 ↗
72. Fang · Environ. Sci. Technol. · 2018 · 52 · 217810.1021/acs.est.7b05303 ↗
73. Al-Alharbi · J. Environ. Chem. Eng. · 2021 · 9 · 10504410.1016/j.jece.2021.105044 ↗
74. Dong · Nat. Commun. · 2022 · 13 · 536510.1038/s41467-022-33098-y ↗
75. Zeeshan · Inorg. Chem. Commun. · 2024 · 162 · 11168710.1016/j.inoche.2023.111687 ↗
76. Beyer · ChemSusChem · 2020 · 13 · 206610.1002/cssc.201903485 ↗
77. Ruipérez · J. Inorg. Biochem. · 2012 · 117 · 11810.1016/j.jinorgbio.2012.09.008 ↗
78. Stoll · J. Magn. Reson. · 2006 · 178 · 4210.1016/j.jmr.2005.08.013 ↗
79. Tobia · J. Nucl. Mater. · 2014 · 451 · 20710.1016/j.jnucmat.2014.03.054 ↗