DataVXNanoscalePaper
journal article·2019

DNA nanostructures from double-C-shaped motifs with controllable twist and curvature

Donglei Yang, Kai Huang, Pengfei Wang, Yongli Mi, Bryan Wei

Nanoscale· Volume 11· Issue 31
Publisher page
Source abstract

Abstract

We demonstrate twist and curvature engineering in DNA nanostructures from the scaffold-free approach. The DNA 'LEGO' bricks adopted in this study are double-C-shaped motifs, and extended nanostructures are constructed to visualize the structural details of twist or curvature. By systematically deleting and inserting base pairs at certain domains of the component motifs, we are able to study various levels of the twist and curvature of the resulting nanostructures comprehensively.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Bacteriophages and microbial interactions

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemical Science and Engineering

Tongji University

Shanghai 200092

China

Institute of Molecular Medicine (IMM)

School of Life Sciences

Tsinghua University-Peking University Center for Life Sciences

Center for Synthetic and Systems Biology

Tsinghua University

Beijing 100084

Renji Hospital

Shanghai Jiao Tong University School of Medicine

Shanghai 200127

Department of Chemical and Biological Engineering

Funding

National Natural Science Foundation of China · Tsinghua University · Peking University · Research Grants Council, University Grants Committee · Tongji University

References (20)

Show source-provided references
1. Chen · Nature · 1991 · 350 · 63110.1038/350631a0 ↗
2. Fu · Biochemistry · 1993 · 32 · 321110.1021/bi00064a003 ↗
3. Winfree · Nature · 1998 · 394 · 53910.1038/28998 ↗
4. Goodman · Science · 2005 · 310 · 166110.1126/science.1120367 ↗
5. Rothemund · Nature · 2006 · 440 · 29710.1038/nature04586 ↗
6. He · Nature · 2008 · 452 · 19810.1038/nature06597 ↗
7. Yin · Science · 2008 · 321 · 82410.1126/science.1157312 ↗
8. Zheng · Nature · 2009 · 461 · 7410.1038/nature08274 ↗
9. Douglas · Nature · 2009 · 459 · 41410.1038/nature08016 ↗
10. Ke · J. Am. Chem. Soc. · 2009 · 131 · 1590310.1021/ja906381y ↗
11. Woo · Nat. Chem. · 2011 · 3 · 62010.1038/nchem.1070 ↗
12. Wei · Nature · 2012 · 485 · 62310.1038/nature11075 ↗
13. Ke · Science · 2012 · 338 · 117710.1126/science.1227268 ↗
14. Dietz · Science · 2009 · 325 · 72510.1126/science.1174251 ↗
15. Han · Science · 2011 · 332 · 34210.1126/science.1202998 ↗
16. Wei · J. Am. Chem. Soc. · 2013 · 135 · 1808010.1021/ja4062294 ↗
17. Yang · Nano Lett. · 2013 · 13 · 186210.1021/nl400859d ↗
18. Liu · Angew. Chem., Int. Ed. · 2006 · 45 · 194210.1002/anie.200504022 ↗
19. Yang · Nucleic Acids Res. · 2017 · 45 · 360610.1093/nar/gkx121 ↗
20. Ke · J. Am. Chem. Soc. · 2006 · 128 · 441410.1021/ja058145z ↗