DataVXNanoscalePaper
journal article·2023Open access

Inducing tumor ferroptosis via a pH-responsive NIR-II photothermal agent initiating lysosomal dysfunction

Zhiwei Zhang, Jingjing Xiang, Lijiao Guan, Pu Chen, Changzhong Li, Chunlei Guo, Yan Hu, Saipeng Huang, Lintao Cai, Ping Gong

Nanoscale· Volume 15· Issue 47
Publisher pageOpen full text
Source abstract

Abstract

Ferroptosis is a unique programmed cell death process that was discovered a few years ago and plays an important role in tumor biology and treatment. However, it still remains a challenge to modulate tumor ferroptosis by spatiotemporally controlled cell-intrinsic Fenton chemistry. Herein, a pH activated photothermal sensitizer IR-PE has been designed and synthesized on the basis of cyanine bearing a diamine moiety, which is capable of triggering the lysosomal dysfunction-mediated Fenton pathway under the irradiation of near-infrared light to evoke ferroptosis, thereby improving antitumor efficacy and mitigating systemic side effects.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Ferroptosis and cancer prognosis · Nanoplatforms for cancer theranostics · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Northwest University, Xi'an 710069, China

Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, CAS Key Lab for Health Informatics, Sino-Euro Center of Biomedicine and Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

University of Chinese Academy of Sciences, Beijing 100049, China

Baoji University of Arts and Sciences, Baoji 721013, China

Peking University Shenzhen Hospital, No. 1120, Lianhua Road, Shenzhen 518036, China

Funding

National Key Research and Development Program of China · Chinese Academy of Sciences · Special Project for Research and Development in Key areas of Guangdong Province · Shenzhen Science and Technology Innovation Program

References (29)

Show source-provided references
1. Kang · Chem. Soc. Rev. · 2023 · 52 · 395510.1039/D3CS00001J ↗
2. Zeng · Angew. Chem., Int. Ed. · 2023 · 62 · e20230037910.1002/anie.202300379 ↗
3. Li · Signal Transduction Targeted Ther. · 2020 · 5 · 10810.1038/s41392-020-00216-5 ↗
4. Jiang · Nat. Rev. Mol. Cell Biol. · 2021 · 22 · 26610.1038/s41580-020-00324-8 ↗
5. Lei · Nat. Rev. Cancer · 2022 · 22 · 38110.1038/s41568-022-00459-0 ↗
6. Jiang · Nat. Commun. · 2020 · 11 · 185710.1038/s41467-020-15730-x ↗
7. Yue · Chem · 2022 · 8 · 195610.1016/j.chempr.2022.03.009 ↗
8. Mancias · Nature · 2014 · 509 · 10510.1038/nature13148 ↗
9. Kroemer · Nat. Rev. Cancer · 2005 · 5 · 88610.1038/nrc1738 ↗
10. Chen · Adv. Fiber Mater. · 2022 · 4 · 166910.1007/s42765-022-00199-8 ↗
11. Wang · Traffic · 2018 · 19 · 91810.1111/tra.12613 ↗
12. Wen · Bioact. Mater. · 2022 · 18 · 242
13. Wen · Nano Today · 2023 · 50 · 10186310.1016/j.nantod.2023.101863 ↗
14. Yu · Nano Today · 2022 · 43 · 10142710.1016/j.nantod.2022.101427 ↗
15. Chen · Cell Death Differ. · 2019 · 27 · 24210.1038/s41418-019-0352-3 ↗
16. Stockwell · Cell · 2017 · 171 · 27310.1016/j.cell.2017.09.021 ↗
17. Xu · Nat. Commun. · 2020 · 11 · 348410.1038/s41467-020-17300-7 ↗
18. Zhao · Mol. Pharm. · 2019 · 16 · 253210.1021/acs.molpharmaceut.9b00132 ↗
19. Zhang · Adv. Fiber Mater. · 2022 · 4 · 80710.1007/s42765-022-00137-8 ↗
20. Wang · Nat. Commun. · 2021 · 12 · 178210.1038/s41467-021-22111-5 ↗
21. Zhu · Cell Death Dis. · 2020 · 11 · 81710.1038/s41419-020-03032-5 ↗
22. Chen · J. Am. Chem. Soc. · 2013 · 136 · 15710.1021/ja406992w ↗
23. Luo · Analyst · 2016 · 141 · 322410.1039/C6AN00467A ↗
24. Perera · Annu. Rev. Cell Dev. Biol. · 2016 · 32 · 22310.1146/annurev-cellbio-111315-125125 ↗
25. Tian · Angew. Chem., Int. Ed. · 2014 · 53 · 954410.1002/anie.201405490 ↗
26. Yang · Adv. Fiber Mater. · 2023 · 5 · 20910.1007/s42765-022-00210-2 ↗
27. Chen · Nat. Rev. Clin. Oncol. · 2021 · 18 · 28010.1038/s41571-020-00462-0 ↗
28. Guan · J. Mater. Chem. B · 2021 · 9 · 890610.1039/D1TB01654G ↗
29. Ou · Angew. Chem., Int. Ed. · 2021 · 60 · 815710.1002/anie.202014852 ↗