Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells
Source abstract
Abstract
A hybrid gene delivery platform, micro Cell Vesicle Technology (mCVT), produced from the fusion of plasma membranes and cationic lipids, is presently used to improve the transfection efficiency of hard-to-transfect (HTT) cells. The plasma membrane components of mCVTs impart specificity in cellular uptake and reduce cytotoxicity in the transfection process, while the cationic lipids complex with the genetic material and provide structural integrity to mCVTs.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: RNA Interference and Gene Delivery · Virus-based gene therapy research · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Pharmacy
National University of Singapore
Singapore
NUS Graduate School for Integrative Sciences and Engineering
Centre for Life Sciences (CeLS)
Department of Surgery
Yong Loo Lin School of Medicine
Cardiovascular Research Institute (CVRI)
Department of Pharmaceutics
School of Materials
Science and Engineering & Lee Kong Chian School of Medicine (LKCmedicine)
Nanyang Technological University
Singapore 639798
School of Pharmacy
University College London
Funding
Ministry of Education - Singapore · National Medical Research Council · Nanyang Technological University · National University of Singapore
References (38)
Show source-provided references
1. Yamano · Mol. Biotechnol. · 2010 · 46 · 28710.1007/s12033-010-9302-5 ↗
2. Kim · Anal. Bioanal. Chem. · 2010 · 397 · 317310.1007/s00216-010-3821-6 ↗
3. Tan · Biomacromolecules · 2007 · 8 · 44810.1021/bm060502q ↗
4. Pannier · Mol. Ther. · 2004 · 10 · 1910.1016/j.ymthe.2004.03.020 ↗
5. Niidome · Gene Ther. · 2002 · 9 · 164710.1038/sj.gt.3301923 ↗
6. Seow · Mol. Ther. · 2009 · 17 · 76710.1038/mt.2009.41 ↗
7. Schmidt-Wolf · Trends Mol. Med. · 2003 · 9 · 6710.1016/S1471-4914(03)00005-4 ↗
8. E. Jubeli , W. P. D.Goldring and M. D.Pungente , in Methods in Molecular Biology , Humana Press Inc. , 2016 , vol. 1445 , pp. 19–32
9. Midoux · Curr. Gene Ther. · 2008 · 8 · 33510.2174/156652308786071014 ↗
10. Prüfert · Nanomedicine · 2017 · 12 · 271310.2217/nnm-2017-0115 ↗
11. Lou · Nat. Biotechnol. · 2000 · 18 · 3310.1038/71889 ↗
12. Holmen · In Vitro Cell Dev. Biol. – Animal · 1995 · 31 · 34710.1007/BF02634283 ↗
13. Washbourne · Curr. Opin. Neurobiol. · 2002 · 12 · 56610.1016/S0959-4388(02)00365-3 ↗
14. Han · Sci. Adv. · 2015 · 1 · e150045410.1126/sciadv.1500454 ↗
15. Kilroy · PLoS One · 2009 · 4 · e694010.1371/journal.pone.0006940 ↗
16. Tietz · J. Biomol. Tech. · 2012 · 23 · 4710.7171/jbt.12-2302-005 ↗
17. Zhao · J. Controlled Release · 2012 · 159 · 10410.1016/j.jconrel.2012.01.007 ↗
18. Yin · J. Immunol. Methods · 2006 · 312 · 110.1016/j.jim.2006.01.023 ↗
19. Novo · Expert Opin. Drug Delivery · 2015 · 12 · 50710.1517/17425247.2015.988136 ↗
20. Ruiz-Ojeda · Adv. Nutr. · 2019 · 10 · S3110.1093/advances/nmy037 ↗
21. Gresch · Methods Mol. Biol. · 2012 · 801 · 6510.1007/978-1-61779-352-3_5 ↗
22. Zotova · Viruses · 2017 · 9 · 32510.3390/v9110325 ↗
23. Teixeira · Int. J. Pharm. · 2017 · 534 · 35610.1016/j.ijpharm.2017.10.030 ↗
24. Goh · Int. J. Nanomed. · 2017 · 12 · 275910.2147/IJN.S131786 ↗
25. Jang · ACS Nano · 2013 · 7 · 769810.1021/nn402232g ↗
26. Goh · Sci. Rep. · 2017 · 7 · 1432210.1038/s41598-017-14725-x ↗
27. Kaneti · Nano Lett. · 2016 · 16 · 157410.1021/acs.nanolett.5b04237 ↗
28. Byun · Gene Ther. · 2004 · 11 · 49210.1038/sj.gt.3302180 ↗
29. Li · Nano Res. · 2018 · 11 · 524010.1007/s12274-018-2179-5 ↗
30. Batrakova · J. Controlled Release · 2015 · 219 · 39610.1016/j.jconrel.2015.07.030 ↗
31. Goh · Nanoscale · 2018 · 10 · 681210.1039/C7NR08720A ↗
32. Wolkers · Langmuir · 2019 · 35 · 752010.1021/acs.langmuir.8b02852 ↗
33. Has · J. Liposome Res. · 2019 · 110.1080/08982104.2019.1668010 ↗
34. Huang · Nat. Biotechnol. · 1997 · 15 · 62010.1038/nbt0797-620 ↗
35. Agirre · Drug Delivery · 2015 · 22 · 10010.3109/10717544.2013.871373 ↗
36. Sancho-Albero · J. Nanobiotechnol. · 2019 · 17 · 1610.1186/s12951-018-0437-z ↗
37. Hazan-Halevy · Cancer Lett. · 2015 · 364 · 5910.1016/j.canlet.2015.04.026 ↗
38. Dordevic · PLoS One · 2014 · 9 · e9938210.1371/journal.pone.0099382 ↗