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journal article·2021Open access

A glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic AND logic gate for smart delivery

Beatriz Mayol, Paula Díez, Alfredo Sánchez, Cristina de la Torre, Anabel Villalonga, Elena Lucena-Sánchez, Félix Sancenón, Paloma Martínez-Ruiz, Diana Vilela, Ramón Martínez-Máñez, Reynaldo Villalonga

Nanoscale· Volume 13· Issue 44
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Source abstract

Abstract

This work describes the assembly of a novel enzyme-controlled nanomachine operated through an AND Boolean logic gate for on-command delivery. The nanodevice was constructed on Au-mesoporous silica Janus nanoparticles capped with a thiol-sensitive gate-like molecular ensemble on the mesoporous face and functionalized with glutathione reductase on the gold face. This autonomous nanomachine employed NADPH and glutathione disulfide as input chemical signals, leading to the enzymatic production of reduced glutathione that causes the disruption of the gating mechanism on the mesoporous face and the consequent payload release as an output signal. The nanodevice was successfully used for the autonomous release of doxorubicin in HeLa cancer cells and RAW 264.7 macrophage cells.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

Nanomaterials

OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Advanced biosensing and bioanalysis techniques · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Nanosensors and Nanomachines Group, Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain

Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Camino de Vera s/n, 46022, Valencia, Spain

Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, Valencia, Spain

CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain

Unidad Mixta de Investigación en Nanomedicina y Sensores. Universitat Politècnica de València, Instituto de Investigación Sanitaria La Fe, Valencia, Spain

Funding

Generalitat Valenciana · Secretaría de Estado de Investigación, Desarrollo e Innovación

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