DataVXNanoscalePaper
journal article·2021

A hydrogel-based implantable multidrug antitubercular formulation outperforms oral delivery

Sanjay Pal, Vijay Soni, Sandeep Kumar, Somesh Kumar Jha, Nihal Medatwal, Kajal Rana, Poonam Yadav, Devashish Mehta, Dolly Jain, Pankaj Sharma, Raunak Kar, Aasheesh Srivastava, Veena S. Patil, Ujjaini Dasgupta, Vinay Kumar Nandicoori, Avinash Bajaj

Nanoscale· Volume 13· Issue 31
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Source abstract

Abstract

We present a non-immunogenic, injectable, low molecular weight, amphiphilic hydrogel-based drug delivery system (TB-Gel) that can entrap a cocktail of four front-line antitubercular drugs, isoniazid, rifampicin, pyrazinamide, and ethambutol. We showed that TB-Gel is more effective than oral delivery of the combination of four drugs in reducing the mycobacterial infection in mice. Results show that half the dose of chemotherapeutic drugs is sufficient to achieve a comparable therapeutic effect to that of oral delivery.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

PolymersBiomaterials

OpenAlex topics: Advanced Drug Delivery Systems · Pneumocystis jirovecii pneumonia detection and treatment · Oral and gingival health research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad-121001, Haryana, India

National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi-110067, India

Amity Institute of Integrative Sciences and Health, Amity University Haryana, Panchgaon, Manesar, Gurgaon-122413, Haryana, India

Department of Chemistry, Indian Institute of Science Education and Research, Bhopal By-pass Road, Bhauri, Bhopal-462066, India

Funding

Department of Science and Technology, Ministry of Science and Technology, India · Regional Centre for Biotechnology · University Grants Commission · Council of Scientific and Industrial Research, India · National Institute of Immunology · Department of Biotechnology, Ministry of Science and Technology, India · Science and Engineering Research Board · Amity University

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