journal article·2022Open access

How an ACE2 mimicking epitope-MIP nanofilm recognizes template-related peptides and the receptor binding domain of SARS-CoV-2

Xiaorong Zhang, Armel T. Waffo, Aysu Yarman, Norbert Kovács, Zsófia Bognár, Ulla Wollenberger, Ibrahim M. El-Sherbiny, Rabeay Y. A. Hassan, Frank F. Bier, Róbert E. Gyurcsányi, Ingo Zebger, Frieder W. Scheller

Nanoscale· Volume 14· Issue 48

Abstract

15-fold lower affinity. Further truncation of the peptides to tetrapeptide (EGFN) and hexapeptide (YFPLQS) results also in a significantly lower affinity. We concluded that the affinity towards the different peptides is mainly determined by the four amino acid motif CYFP present in the sequence of the template peptide. A higher affinity than that for the peptides is found for the parent proteins RBD and spike protein, which seems to be due to out of cavity effects caused by their larger footprint on the nanofilm surface.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · SARS-CoV-2 detection and testing · Biosensors and Analytical Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht Str. 24–25, 14476 Potsdam, Germany

Institut für Chemie, PC 14 Technische Universität Berlin, Straße des 17. Juni 135, 10623 Berlin, Germany

Molecular Biotechnology, Faculty of Science, Turkish-German University, Sahinkaya Cad, 86, Beykoz, Istanbul 34820, Turkey

Department of Inorganic and Analytical Chemistry, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary

ELKH-BME Computation Driven Chemistry Research Group, Műegyetem rkp. 3, H-1111 Budapest, Hungary

Nanoscience Program, University of Science and Technology (UST) & Center for Materials Science (CMS), Zewail City of Science and Technology, Giza 12578, Egypt

Funding

Innovációs és Technológiai Minisztérium · Bundesministerium für Bildung und Forschung · Deutsche Forschungsgemeinschaft

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