A specific HeLa cell-labelled and lysosome-targeted upconversion fluorescent probe: PEG-modified Sr 2 YbF 7 :Tm 3+
Source abstract
Abstract
In this study, water-soluble PEG-modified Sr2YbF7:Tm3+ was prepared conveniently by a one-pot solvothermal method, where the molar ratio of Sr2+ to Yb3+ was controlled between 3 : 2 and 1 : 1. The optimum red-light emission at 677-699 nm was modulated via 0.7% Tm3+ doped under irradiation at 980 nm. Interestingly, biological experimental results showed that the PEG-modified Sr2YbF7:Tm3+ with low toxicity, excellent cell membrane permeability and high photostability can not only distinguish HeLa cells from mouse embryonic fibroblasts but also target the subcellular organelle lysosome in HeLa cells; therefore it can be anticipated that the as-prepared material would be a potential tool for cancer diagnosis.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Luminescence Properties of Advanced Materials · Lanthanide and Transition Metal Complexes · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Chemistry and Chemical Engineering
Anhui University and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials
Hefei
P. R. China
Department of Physics
Hengyang Normal University
Hengyang
References (38)
Show source-provided references
1. Zeng · Biomaterials · 2012 · 33 · 923210.1016/j.biomaterials.2012.09.019 ↗
2. Zhou · Chem. Soc. Rev. · 2012 · 41 · 132310.1039/C1CS15187H ↗
3. Wang · Chem. Soc. Rev. · 2009 · 38 · 97610.1039/b809132n ↗
4. Wang · Analyst · 2010 · 135 · 183910.1039/c0an00144a ↗
5. Yi · Adv. Funct. Mater. · 2006 · 16 · 232410.1002/adfm.200600053 ↗
6. Chen · ACS Nano · 2010 · 4 · 316310.1021/nn100457j ↗
7. Li · Adv. Mater. · 2008 · 20 · 476510.1002/adma.200801056 ↗
8. Boyer · J. Am. Chem. Soc. · 2006 · 128 · 744410.1021/ja061848b ↗
9. Gong · J. Am. Chem. Soc. · 2013 · 135 · 845210.1021/ja4027715 ↗
10. Chen · Chem. Rev. · 2014 · 6 · 753
11. Li · Analyst · 2013 · 138 · 158910.1039/c3an36601d ↗
12. Kramer · Chem. Mater. · 2004 · 16 · 124410.1021/cm031124o ↗
13. Ding · Adv. Healthcare Mater. · 2016 · 5 · 174010.1002/adhm.201600074 ↗
14. Saidak · Pharmacol. Ther. · 2012 · 136 · 21610.1016/j.pharmthera.2012.07.009 ↗
15. Huang · Small · 2016 · 12 · 420010.1002/smll.201601023 ↗
16. Li · J. Am. Ceram. Soc. · 2015 · 98 · 382410.1111/jace.13804 ↗
17. Wang · Chem. Soc. Rev. · 2017 · 46 · 415010.1039/C7CS00053G ↗
18. Deng · Nano Res. · 2011 · 4 · 68510.1007/s12274-011-0124-y ↗
19. Xiang · Opt. Mater. · 2015 · 49 · 610.1016/j.optmat.2015.08.014 ↗
20. Mao · J. Alloys Compd. · 2014 · 609 · 26210.1016/j.jallcom.2014.04.168 ↗
21. Zhang · Nanoscale · 2011 · 3 · 96310.1039/c0nr00823k ↗
22. Heer · Adv. Mater. · 2004 · 16 · 210210.1002/adma.200400772 ↗
23. Ren · J. Phys. Chem. C · 2011 · 115 · 2014110.1021/jp2064529 ↗
24. Suna · Mater. Chem. Phys. · 2010 · 123 · 80610.1016/j.matchemphys.2010.05.064 ↗
25. Yan · Adv. Funct. Mater. · 2015 · 20 · 1162
26. Passuello · Opt. Mater. · 2011 · 33 · 64310.1016/j.optmat.2010.11.017 ↗
27. Sun · Mater. Chem. Phys. · 2010 · 123 · 80610.1016/j.matchemphys.2010.05.064 ↗
28. Tyagi · J. Mater. Sci. Lett. · 1999 · 18 · 54910.1023/A:1006626527995 ↗
29. Vetrone · Chem. Mater. · 2009 · 21 · 184710.1021/cm900313s ↗
30. Du · J. Alloys Compd. · 2011 · 509 · 341310.1016/j.jallcom.2010.12.101 ↗
31. Wang · J. Am. Chem. Soc. · 2008 · 83 · 761
32. Fang · Adv. Drug Delivery Rev. · 2011 · 63 · 13610.1016/j.addr.2010.04.009 ↗
33. Torchilin · Adv. Drug Delivery Rev. · 2011 · 63 · 13110.1016/j.addr.2010.03.011 ↗
34. Maedaa · J. Controlled Release · 2001 · 74 · 4710.1016/S0168-3659(01)00309-1 ↗
35. Maeda · J. Controlled Release · 2000 · 65 · 27110.1016/S0168-3659(99)00248-5 ↗
36. Maruyama · Biochimica et Biophysica Acta, Biomembranes · 1995 · 1234 · 7410.1016/0005-2736(94)00263-O ↗
37. Kong · Nanoscale · 2017 · 9 · 790110.1039/C6NR08883J ↗
38. Chen · Anal. Chem. · 2012 · 84 · 309910.1021/ac202810b ↗