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journal article·2020Open access

Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse

Alexandra Brito, Patrícia M. R. Pereira, Rui L. Reis, Rein V. Ulijn, Jason S. Lewis, Ricardo A. Pires, Iva Pashkuleva

Nanoscale· Volume 12· Issue 37
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Source abstract

Abstract

Spheroids recapitulate the organization, heterogeneity and microenvironment of solid tumors. Herein, we targeted spatiotemporally the accelerated metabolism of proliferative cells located on the spheroid surface that ensure structure maintenance and/or growth. We demonstrate that phosphorylated carbohydrate amphiphile acts as a potent antimetabolite due to glycolysis inhibition and to in situ formation of supramolecular net around spheroid surface where alkaline phosphatase is overexpressed. The efficiency of the treatment is higher in spheroids as compared to the conventional 2D cultures because of the 2-fold higher expression of glucose transporter 1 (GLUT1). Moreover, treated spheroids do not undergo following relapse.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Cancer, Hypoxia, and Metabolism · Cancer, Lipids, and Metabolism · Metabolomics and Mass Spectrometry Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

3B's Research Group

I3Bs - Research Institute on Biomaterials

Biodegradables and Biomimetics

University of Minho

Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine

Department of Radiology

Memorial Sloan Kettering Cancer Center

USA

Advanced Science Research Center (ASRC) at the Graduate Center

City University of New York (CUNY)

New York

Department of Chemistry

Weill Cornell Medical College

Funding

Horizon 2020 Framework Programme · Fundação para a Ciência e a Tecnologia · Army Research Laboratory · Army Research Office · National Science Foundation · Liga Portuguesa Contra o Cancro · National Institutes of Health · Tow Foundation

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