A scalable process to produce lipid-based compartmented Janus nanoparticles with pharmaceutically approved excipients
Source abstract
Abstract
In the field of nanotechnologies, theranostic approaches and fixed-dose combination products require the development of innovative carriers able to co-encapsulate several entities of interest. This communication describes the preparation and characterization of lipid-based Janus compartmented nanoparticles. They were successfully prepared using a scalable process with pharmaceutically approved excipients. The analysis of the microscopic structure and supramolecular organization demonstrated the formation of two physico-chemically different compartments enabling the co-administration at once of both liposoluble and hydrosoluble active pharmaceutical ingredients.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Pickering emulsions and particle stabilization · Innovative Microfluidic and Catalytic Techniques Innovation · Proteins in Food Systems
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institut Galien Paris-Sud, Université Paris-Saclay, Univ. Paris-Sud, Labex LERMIT, 5 rue Jean-Baptiste Clément, Châtenay-Malabry 92296, France
Institute of Inorganic Chemistry, Graz University of Technology, Stremayergasse 9/IV, 8010 Graz, Austria
Institut de Biologie Paris-Seine (IBPS) FR 3631 Université Pierre et Marie Curie-CNRS, 9 quai St Bernard, 75252 Paris Cedex 05, France
References (39)
Show source-provided references
1. DeGennes · Angew. Chem., Int. Ed. Engl. · 1992 · 31 · 84210.1002/anie.199208421 ↗
2. Tran · Expert Opin. Drug Delivery · 2014 · 11 · 106110.1517/17425247.2014.915806 ↗
3. Du · Chem. Soc. Rev. · 2011 · 40 · 240210.1039/c0cs00216j ↗
4. Walther · Chem. Rev. · 2013 · 113 · 519410.1021/cr300089t ↗
5. Puri · Crit. Rev. Ther. Drug. Carrier Syst. · 2009 · 26 · 52310.1615/CritRevTherDrugCarrierSyst.v26.i6.10 ↗
6. Ponchel · Eur. J. Pharm. Biopharm. · 1997 · 44 · 2510.1016/S0939-6411(97)00098-2 ↗
7. Dawson · Biotechnol. Prog. · 2004 · 20 · 85110.1021/bp0342553 ↗
8. Li · Int. J. Nanomed. · 2011 · 6 · 3151
9. Iversen · Nano Today · 2011 · 6 · 17610.1016/j.nantod.2011.02.003 ↗
10. Zhao · Small · 2011 · 7 · 132210.1002/smll.201100001 ↗
11. Svensson · Int. J. Pharm. · 2004 · 281 · 10710.1016/j.ijpharm.2004.06.005 ↗
12. Morán · J. Phys. Chem. B · 2005 · 109 · 2289910.1021/jp053093l ↗
13. Guo · Drug Discovery Today · 2010 · 15 · 103210.1016/j.drudis.2010.09.006 ↗
14. Angelov · Phys. Chem. Chem. Phys. · 2011 · 13 · 307310.1039/C0CP01029D ↗
15. Wang · Nanoscale · 2015 · 7 · 1034410.1039/C5NR01999K ↗
16. Lattuada · Nano Today · 2011 · 6 · 28610.1016/j.nantod.2011.04.008 ↗
17. Mason · J. Phys.: Condens. Matter · 2006 · 18 · 635
18. Klang · Micron · 2012 · 43 · 8510.1016/j.micron.2011.07.014 ↗
19. Teixeira · Pharm. Res. · 2000 · 17 · 132910.1023/A:1026416208482 ↗
20. Raffournier · Prog. Colloid Polym. Sci. · 2004 · 128 · 139
21. Paliwal · Int. J. Pharm. · 2009 · 380 · 18110.1016/j.ijpharm.2009.06.026 ↗
22. M. J.Schick , Nonionic Surfactants: Physical Chemistry , CRC Press , 1987 , 1158p
23. Einaga · Polym. J. · 2009 · 41 · 15710.1295/polymj.PJ2008244 ↗
24. Reissig · Langmuir · 2010 · 26 · 1519210.1021/la102726r ↗
25. Kunieda · J. Phys. Chem. B · 1997 · 101 · 795210.1021/jp9713322 ↗
26. Janib · Adv. Drug Delivery Rev. · 2010 · 62 · 105210.1016/j.addr.2010.08.004 ↗
27. T.Kararli , K.Sedo and J.Bossart , Drug Dev. Delivery , 2014 , http://www.drug-dev.com/Main/Back-Issues/FIXEDDOSE-COMBINATIONS-FixedDose-Combination-Produ-661.aspx
28. Lee · J. Drug Delivery · 2012 · 1
29. Ma · ACS Nano · 2013 · 7 · 951810.1021/nn405674m ↗
30. G.Gregoriadis , Liposome Technology: Entrapment of drugs and Other Materials into Liposomes , 2007 , CRC Press , 398p
31. Magalhaes · Biotechnol. Appl. Biochem. · 2001 · 33 · 6110.1042/BA20000080 ↗
32. Noble · Cancer Chemother. Pharmacol. · 2009 · 64 · 74110.1007/s00280-008-0923-3 ↗
33. Xie · Langmuir · 2012 · 28 · 445910.1021/la2042185 ↗
34. Hwang · Macromol. Rapid Commun. · 2012 · 33 · 117810.1002/marc.201200054 ↗
35. Tran · Nano Lett. · 2015 · 15 · 422910.1021/acs.nanolett.5b01751 ↗
36. Kydd · Pharmaceutics · 2017 · 9 · 4610.3390/pharmaceutics9040046 ↗
37. Brubach · J. Phys. Chem. B · 2004 · 108 · 1772110.1021/jp047989m ↗
38. El Hadri · J. Mol. Struct. · 2015 · 1083 · 44110.1016/j.molstruc.2014.10.062 ↗
39. El Hadri · Chem. Phys. Lipids · 2016 · 200 · 1110.1016/j.chemphyslip.2016.05.005 ↗