Membrane-containing virus particles exhibit the mechanics of a composite material for genome protection
Source abstract
Abstract
The protection of the viral genome during extracellular transport is an absolute requirement for virus survival and replication. In addition to the almost universal proteinaceous capsids, certain viruses add a membrane layer that encloses their double-stranded (ds) DNA genome within the protein shell. Using the membrane-containing enterobacterial virus PRD1 as a prototype, and a combination of nanoindentation assays by atomic force microscopy and finite element modelling, we show that PRD1 provides a greater stability against mechanical stress than that achieved by the majority of dsDNA icosahedral viruses that lack a membrane. We propose that the combination of a stiff and brittle proteinaceous shell coupled with a soft and compliant membrane vesicle yields a tough composite nanomaterial well-suited to protect the viral DNA during extracellular transport.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bacteriophages and microbial interactions · RNA and protein synthesis mechanisms · Bacterial Genetics and Biotechnology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Molecular recognition and host–pathogen interactions programme
CIC bioGUNE
CIBERehd
Derio
Spain
Biosurfaces Lab
CIC biomaGUNE
San Sebastian
Mechanical and Industrial Production Department
Mondragon University
Arrasate-Mondragón
Molecular and Integrative Biosciences Research Programme
Faculty of Biological and Environmental Sciences
Viikki Biocenter
University of Helsinki
Finland
Centro de Física de Materiales
(CSIC-UPV/EHU) & Donostia International Physics Center
School of Biomedical Sciences
Funding
Ministerio de Economía y Competitividad · Helsingin Yliopisto · FP7 Ideas: European Research Council · Suomen Akatemia
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